Sub-acute and chronic toxicity profiles of Markhamia tomentosa ethanolic leaf extract in rats

Ibrahim, Mutiat B.; Sowemimo, Abimbola; Sofidiya, Margaret O.; Badmos, KB; Fageyinbo, Muyiwa Samuel; Abdulkareem, Fatimah B.; Odukoya, Onatolu

doi:10.1016/j.jep.2016.07.036

Cited by 47 publications

(36 citation statements)

References 20 publications

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“…Our study indicated a significant dose-dependent increase in platelet count in male and female rats in contrast to the control group which may suggest the triggering role of M. oleifera in thrombopoiesis (Ibrahim et al, 2016). However, other blood cell counts were not altered in the subchronic toxicity study in treated groups in contrast to normal in both sexes as similar findings reported previously (Jin et al, 2018).…”

Section: Discussionsupporting

confidence: 89%

“…Regardless of the promising global practice of herbal therapies for curing and managing chronic diseases such as cancer, diabetes, arthritis, etc., there arise considerable safety issues complemented to it (Ibrahim et al., 2016). Traditional healers mostly designate herbal therapy as natural and safe treatment; however, it is contentious for non‐food herbal products that are not evaluated comprehensively for toxicological inferences (Afolabi, Akindele, Awodele, Anunobi, & Adeyemi, 2012).…”

Section: Introductionmentioning

confidence: 99%

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HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Saleem

Akhtar

et al. 2020

J. Food Biochem.

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The study was planned to evaluate toxicity of M. oleifera leaf methanol extract in Wistar rats, cytotoxic potential and chemically characterize it. Acute toxicity study revealed no mortality at 2,000 mg/kg dose. In subchronic toxicity, 150, 300, and 600 mg/kg extract were administered in both sexes for 90 days. A decrease in body weight, cholesterol, and low-density lipoproteins, as well as an increase in the platelet count were observed. The histology of heart, lung, and kidney was normal. The oxidative stress biomarkers were normal in the liver tissue. In vitro cytotoxicity assay revealed that IC50 of the plant extract was more than 1,000 µg/ml. FTIR explored various functional groups and HPLC analysis indicated the presence of kaempferol and quercetin in the plant extract. These results showed that the plant extract might be safe up to 2,000 mg/kg single dose. The long term use of the plant extract was mostly devoid of major system toxicities. Practical applications M. oleifera is a multipurpose tree. It is a cruciferous plant that has nutritional as well as medicinal properties. It is exhibited a multitude of nutraceutical or pharmacological properties such as anti-inflammatory, lipid-lowering, anticancer, hypoglycemic, and antihypertensive activities. It is widely used by local inhabitants for their health, food, agriculture, and cosmetic purposes. Among other plant parts, its leaves are mostly used as a functional food because of abundant proteins, β-carotene, polyphenol, vitamin C, and vitamin E. The current study was designed to validate its safety in acute and long term use. The data of this study suggested that the plant can be safely used as a nutraceutical as well as a nutritional food.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Saleem

Akhtar

et al. 2020

J. Food Biochem.

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“…The principal aim of evaluating the safety of any medicinal plant is to identify the nature and significance of adverse effect and to establish the exposure level at which this effect is observed (Ibrahim et al., 2016). The results of the acute toxicity study indicate that the aqueous extract of the aerial parts of Caralluma dalzielii administered through oral route to rats and mice at 175, 500 and 2000 mg/kg using the up and down method of acute toxicity testing did not produce any sign of toxicity and death in the animals.…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of haematological parameters are used to study the extent of toxicity of drug substances including plant extracts (Ibrahim et al., 2016). Haematopoiesis is the process of blood cell formation.…”

Section: Discussionmentioning

confidence: 99%

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Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats

Ugwah‐Oguejiofor

Okoli

Ugwah

et al. 2019

Heliyon

100

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Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential toxicity of aqueous extract of aerial parts of Caralluma dalzielii (AECD) through acute and sub-acute oral administration in mice and rats. During acute toxicity study, female mice and rats were orally administered with AECD at single doses of 175, 500 and 2000 mg/kg according to OECD Guidelines 425. Sub-acute toxicity of AECD (150, 300 and 600 mg/kg p.o) was studied by daily dosing of Wistar rats of both sexes for 28 days. The acute toxicity study revealed no lethal effects and behavioural signs of toxicity at the tested doses indicating that LD50 is greater than 2000 mg/kg. In sub-acute study, a significant reduction in the body weight (p < 0.05), feed and water (p < 0.001) intake of the rats were observed. A significant (p < 0.05) increase in lymphocytes, mean platelet volume counts and alanine aminotransferase were also observed. Histopathological analysis showed mild liver cell distortion in female rats treated at 600 mg/kg of AECD. These results show low toxicity of AECD on short-term use and liver toxicity on long-term use.

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Toxicity, Pharmacokinetic Profile, and Compound-Protein Interaction Study of Polygonum minus Huds Extract

Qader¹,

Özdemir

Benjamin

et al. 2023

Appl Biochem Biotechnol

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Sub-acute and chronic toxicity profiles of Markhamia tomentosa ethanolic leaf extract in rats

Cited by 47 publications

References 20 publications

HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

HPLC analysis, cytotoxicity, and safety study ofMoringa oleiferaLam. (wild type) leaf extract

Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats

Toxicity, Pharmacokinetic Profile, and Compound-Protein Interaction Study of Polygonum minus Huds Extract

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