Sub-100 ps coincidence time resolution for positron emission tomography with LSO:Ce codoped with Ca

Nemallapudi, Mythra Varun; Gundacker, S.; Lecoq, P.; Auffray, E.; Ferri, Alessandro; Gola, A.; Piemonte, C.

doi:10.1088/0031-9155/60/12/4635

Cited by 130 publications

(86 citation statements)

References 18 publications

(19 reference statements)

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“…With this additional information, the SNR in the reconstructed PET images can be improved significantly [92]. Thanks to recent improvements in detector technology, new scintillator materials and fast digital SiPMs photodetectors [93], ToF resolution can be significantly improved; the latest developments in PET detector technology aim at timing resolutions of 100 ps FWHM, or less [92,94].…”

Section: Time-of-flight Petmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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State-of-the-art patient management frequently requires the use of non-invasive imaging methods to assess the anatomy, function or molecular-biological conditions of patients or study subjects. Such imaging methods can be singular, providing either anatomical or molecular information, or they can be combined, thus, providing "anato-metabolic" information. Hybrid imaging denotes image acquisitions on systems that physically combine complementary imaging modalities for an improved diagnostic accuracy and confidence as well as for increased patient comfort. The physical combination of formerly independent imaging modalities was driven by leading innovators in the field of clinical research and benefited from technological advances that permitted the operation of PET and MR in close physical proximity, for example. This review covers milestones of the development of various hybrid imaging systems for use in clinical practice and small-animal research. Special attention is given to technological advances that helped the adoption of hybrid imaging, as well as to introducing methodological concepts that benefit from the availability of complementary anatomical and biological information, such as new types of image reconstruction and data correction schemes. The ultimate goal of hybrid imaging is to provide useful, complementary and quantitative information during patient work-up. Hybrid imaging also opens the door to multi-parametric assessment of diseases, which will help us better understand the causes of various diseases that currently contribute to a large fraction of healthcare costs.

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Section: Time-of-flight Petmentioning

confidence: 99%

Hybrid Imaging: Instrumentation and Data Processing

et al. 2018

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“…Time resolution of ~200 ps is reported for detectors based on LYSO:Ce [5] and PWO with readout using avalanche photodiodes [6]. Sub-100-ps coincidence time resolution for PET with LSO:Ce codoped with Ca is reported [7].…”

Section: Introductionmentioning

confidence: 99%

Luminescence rise time in self-activated PbWO4 and Ce-doped Gd3Al2Ga3O12 scintillation crystals

Auffray

Augulis

Borisevich³

et al. 2016

Journal of Luminescence

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Highlights: Photoluminescence rise time is studied in two scintillators: PWO and GAGG:Ce This study is encouraged by the necessity to find novel detection methods enabling a sub-10-ps time resolution in scintillation detectors and is focused on the exploitation of fast luminescence rise front. Time-resolved photoluminescence (PL) spectroscopy and thermally stimulated luminescence techniques have been used to study two promising scintillators: self-activated lead tungstate (PWO, PbWO4) and Ce-doped gadolinium aluminum gallium garnet (GAGG, Gd3Al2Ga3O12). A sub-picosecond PL rise time is observed in PWO, while longer processes in the PL response in GAGG:Ce are detected and studied. The mechanisms responsible for the PL rise time in selfactivated and doped scintillators are under discussion.

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“…Moreover, the performances of the FBK SiPMs coupled to LSO crystals are superior to those of Hamamatsu SiPMs we used for LYSO crystals. As a matter of fact, the former exhibit better photon collection efficiency due to the absence of an optical window on top of the SiPM and a better single photon time resolution [4]. Finally, SiPMs in this configuration were directly plugged into the readout board, as opposed to the LYSO configuration, which prevented degradation of the performance due to pick-up noise.…”

Section: Discussionmentioning

confidence: 99%

“…In this field too, precise timing is a valuable information to allow so-called time-of-flight PET and improve the image signal-to-noise ratio [2,3]. Recent R&D activity in this field has demonstrated the capability of reaching sub-100 ps FWHM CTR values with LSO:Ce crystals codoped with Ca and coupled to optimized SiPM detectors [4].…”

Section: Introductionmentioning

confidence: 99%

Detection of high energy muons with sub-20 ps timing resolution using L(Y)SO crystals and SiPM readout

Benaglia

Gundacker

Lecoq

et al. 2016

Nuclear Instruments and Methods in Physics Research Section A:

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a b s t r a c tPrecise timing capability will be a key aspect of particle detectors at future high energy colliders, as the time information can help in the reconstruction of physics events at the high collision rate expected there. Other than being used in detectors for PET, fast scintillating crystals coupled to compact Silicon Photomultipliers (SiPMs) constitute a versatile system that can be exploited to realize an ad-hoc timing device to be hosted in a larger high energy physics detector. In this paper, we present the timing performance of LYSO:Ce and LSO:Ce codoped 0.4% Ca crystals coupled to SiPMs, as measured with 150 GeV muons at the CERN SPS H2 extraction line. Small crystals, with lengths ranging from 5 mm up to 30 mm and transverse size of × 2 2 mm 2 or × 3 3 mm 2 , were exposed to a 150 GeV muon beam. SiPMs from two different companies (Hamamatsu and FBK) were used to detect the light produced in the crystals. The best coincidence time resolution value of ( ± ) 14.5 0.5 ps, corresponding to a single-detector time resolution of about 10 ps, is demonstrated for 5 mm long LSO:Ce,Ca crystals coupled to FBK SiPMs, when time walk corrections are applied.

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Sub-100 ps coincidence time resolution for positron emission tomography with LSO:Ce codoped with Ca

Cited by 130 publications

References 18 publications

Hybrid Imaging: Instrumentation and Data Processing

Hybrid Imaging: Instrumentation and Data Processing

Luminescence rise time in self-activated PbWO4 and Ce-doped Gd3Al2Ga3O12 scintillation crystals

Detection of high energy muons with sub-20 ps timing resolution using L(Y)SO crystals and SiPM readout

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