Sub-1-micron mesoporous silica particles functionalized with cyclodextrin derivative for rapid enantioseparations on ultra-high pressure liquid chromatography

Chiral Separations: A Review of Current Topics and Trends

“…Ultrahigh pressure liquid chromatography was employed with perphenylcarbamoylated β-cyclodextrin on sub-1-μm mesoporous silica particles and was tested by the enantioseparation of six basic and neutral racemates. 26 This CSP had low back-pressure with a maximum flow rate of 2 mL/min and showed good enantioresolution of the test solutes.…”

Preparation and chromatographic evaluation of a cysteine-bonded zwitterionic hydrophilic interaction liquid chromatography stationary phase

“…Subsequently, the "thiol-ene" click reaction between vinyl silica and cysteine was carried out in the presence of AIBN to obtain the resulting material Click TE-Cys. The "thiol-ene" reaction, which was identified as a click reaction in 2007 [31], has been utilized in the preparation of chromatographic stationary phases [32][33][34]. Different from the classical Cu(I)-catalyzed alkyne-azide Huisgen click reaction [17], the copper-free "thiol-ene" click reaction can avoid the leaving of heavy metal ions in the stationary phase.…”

Chiral separation of quinolones by liquid chromatography and capillary electrophoresis

“…A decrease of the particle size reduces the axial dispersion and the intraparticle diffusion path, and the core–shell technology still more cuts down the intraparticle diffusion path, reducing the respective contribution to the peak broadening. Recently, these technologies have been employed in chiral chromatography, yielding excellent results . One may expect that, if the chemistry of a CSP is favorable with respect to enantiomer separation of a certain quinolone, the application of this CSP in the form of sub‐3 μm or core–shell particles will improve analytical characteristics of the separation essentially.…”