Su2035 Functional Bowel Symptoms in Quiescent Inflammatory Bowel Diseases: Role of Epithelial Barrier Disruption and Low Grade Inflammation

Vivinus-Nébot, Mylène; Frin, Gregory; Bzioueche, Hanene; Dainese, Raffaella; Bernard, Ghislaine; Anty, Rodolphe; Filippi, Jérôme; Saint–Paul, Marie–Christine; Tulic, Meri K.; Verhasselt, Valérie; Hébuterne, Xavier; Piche, Thierry

doi:10.1016/s0016-5085(13)61997-6

Cited by 4 publications

(2 citation statements)

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“…Thus, there was no evidence of any major differences in the SIP immune profiles of the groups, suggesting that low-grade inflammatory events may not be the main driving factor of the presence of IBS-like symptoms among UC patients in remission. Nevertheless, increased visceral hypersensitivity, 28 along with intestinal permeability and low-grade inflammation, 29 has been reported in IBD patients in remission with IBS-like symptoms as compared with IBD patients in remission without these symptoms. 28 To determine if local events such as lowgrade inflammation, impaired barrier integrity, or neurobiological processes drive symptoms among the UCR + IBS group, broad analysis panels exploring these parameters could be of use.…”

Section: Discussionmentioning

confidence: 98%

Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms

Moraes

Magnusson

Mavroudis

et al. 2020

Inflammatory Bowel Diseases

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Background Inflammatory mechanisms of ulcerative colitis (UC) and irritable bowel syndrome (IBS) may overlap or are part of different spectrums. However, potential links between inflammation and IBS-like symptoms in these patient groups are still unclear. The aim of this study was to determine if the systemic inflammatory protein (SIP) profiles differ between UC patients, with presence of inflammation or in remission with or without IBS-like symptoms, and IBS patients. Methods Serum from patients with active UC (UCA), UC patients in remission with or without IBS-like symptoms (UCR + IBS, UCR-IBS), IBS patients (IBS), and healthy subjects (HS) was analyzed using the ProSeek Multiplex Inflammation kit, which detects 92 proteins. Results The exploratory cohort consisted of 166 subjects (UCA, n = 40; UCR-IBS, n = 45; UCR + IBS, n = 20; IBS, n = 40; HS, n = 21). Systemic inflammatory protein profiles separated UC from non-UC (HS and IBS) patients in multivariate analysis, revealing caspase 8, axin 1, sulfotransferase 1A1, and tumor necrosis factor superfamily member 14 as the variables most important to clustering. Although minor differences were detected between UCR + IBS and UCR-IBS, SIP profiles discriminated UCA from UCR, and interleukin (IL) 17C, IL17A, chemokine ligand 9, and transforming growth factor–α characterized active inflammation. SIP profiles weakly discriminated HS from IBS, although fibroblast growth factor 21 and IL6 serum levels were higher in IBS. Results were confirmed in a validation cohort (UCA, n = 15; UCR + IBS, n = 9; IBS, n = 14). Conclusions SIP profiles distinguish UC patients from IBS patients, irrespective of inflammation or IBS-like symptoms, suggesting that inflammatory mechanisms of the diseases are part of different spectrums.

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Section: Discussionmentioning

confidence: 98%

Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms

Moraes

Magnusson

Mavroudis

et al. 2020

Inflammatory Bowel Diseases

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“…Previous studies have demonstrated abnormal histological findings in a substantial proportion of patients with UC in clinical and endoscopic remission . A recent study suggested that increased paracellular permeability due to occult inflammation may cause irritable bowel syndrome (IBS)‐like symptoms in patients with quiescent inflammatory bowel disease . Chronic colonic inflammation may damage the enteric nervous system, leading to dysregulation of colonic smooth muscle activity .…”

Section: Discussionmentioning

confidence: 99%

Randomised clinical study: discrepancies between patient‐reported outcomes and endoscopic appearance in moderate to severe ulcerative colitis

Jharap

Sandborn

Reinisch

et al. 2015

Aliment Pharmacol Ther

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SummaryBackgroundAssociations between patient‐reported outcomes and mucosal healing have not been established in ulcerative colitis (UC).AimTo evaluate relationships of rectal bleeding and stool frequency with mucosal healing and quality of life (QoL) in patients with UC in two Phase 3 studies (ULTRA 1 and 2).MethodsAssociations of patient‐reported rectal bleeding and stool frequency subscores with mucosal healing (Mayo endoscopy subscore = 0 or 0/1) and QoL [inflammatory bowel disease questionnaire (IBDQ)] were assessed in adalimumab‐randomised patients (160/80 mg at Weeks 0/2 followed by 40 mg biweekly or weekly) at Weeks 8 (n = 433) and 52 (n = 299), and in patients with mucosal healing [endoscopy subscore = 0 (n = 17); 0/1 (n = 52)] at Weeks 8 and 52.ResultsAt Week 8, the positive predictive values (PPVs) of rectal bleeding subscore = 0, stool frequency subscore = 0 or both scores = 0 for endoscopy subscore = 0/1 were 69%, 84% and 90% respectively; all proportions increased at Week 52. Equivalent PPVs for these subscores in patients with endoscopy subscore = 0 were 26%, 37% and 46% respectively. Among patients with endoscopy subscore = 0 at Week 8, 87% reported no rectal bleeding, while only 29% reported normal stool frequency; these proportions had increased to 94% and 41% respectively, at Week 52. Among patients with mucosal healing, IBDQ scores trended highest for patients with both rectal bleeding and stool frequency subscores = 0.ConclusionsAbsence of rectal bleeding and normal stool frequency are often predictive of mucosal healing and QoL, but complete normalisation of stool frequency is encountered rarely in patients with mucosal healing.

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Lactobacillus plantarum HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice through regulating gut microbiome

Liu

et al. 2022

Food Funct.

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Su2035 Functional Bowel Symptoms in Quiescent Inflammatory Bowel Diseases: Role of Epithelial Barrier Disruption and Low Grade Inflammation

Cited by 4 publications

References 0 publications

Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms

Systemic Inflammatory Protein Profiles Distinguish Irritable Bowel Syndrome (IBS) and Ulcerative Colitis, Irrespective of Inflammation or IBS-Like Symptoms

Randomised clinical study: discrepancies between patient‐reported outcomes and endoscopic appearance in moderate to severe ulcerative colitis

Lactobacillus plantarum HNU082 alleviates dextran sulfate sodium-induced ulcerative colitis in mice through regulating gut microbiome

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