“…This is approximately three times that of a 10 Ci HDR 192 Ir source. 9 The XAEBS was approved by the FDA to be used in intracavitary accelerated partial breast irradiation, 10 endometrial treatments, 11 intra-operative radiation therapy, 12 and skin cancer treatment using surface applicators. 13 Photon spectra, 9,14 depth dose modulation, 15 tissue heterogeneities, [16][17][18][19] relative biological effectiveness, 17 and intensity modulated electronic brachytherapy 20 for XAEBS are not well-understood and require further investigation.…”