Characteristics of miniature electronic brachytherapy x‐ray sources based on TG‐43U1 formalism using Monte Carlo simulation techniques

Safigholi, Habib; Faghihi, Reza; Jashni, S Karimi; Meigooni, Ali S.

doi:10.1118/1.3693046

Cited by 17 publications

(40 citation statements)

References 24 publications

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“…We evaluated the spectrum of eBT in our previous works 14 , 20 , 22 . The results show that the maximum differences of 30 keV and 50 keV eBT spectra for dose ratio with 0.5 cm bone were less than 8% and 5.5%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, this technique does not include any radioactive element, and it is easier to possess in term of the regulatory requirements. Clinical benefit of this system has been discussed by various investigators, and the dosimetric characteristics of eBT have been published in different scientific journals 12 , 13 , 14 , 15 . However, all of these publications indicate that eBT is an excellent technique for treatment of skin cancers in homogeneous condition.…”

Section: Discussionmentioning

confidence: 99%

“…In these simulations, the monoenergetic photon beams of 10 keV, 15 keV, 20 keV, 30 keV, 50 keV, and 70 keV for covering the energy range of eBT, 380 keV photons for IR‐HDRS, and 4 MeV and 6 MeV monoenergetic electron beam for EEBRT were modeled. Moreover this work has been benchmarked with actual eBT spectrum, according our previous published results for 30 keV and 50 keV 14 , 20 , 22 …”

Section: Methodsmentioning

confidence: 99%

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Optimum radiation source for radiation therapy of skin cancer

Safigholi

Song

Meigooni

2015

J Applied Clin Med Phys

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Several different applicators have been designed for treatment of skin cancers, such as scalp, hand, and legs using Ir‐192 HDR brachytherapy sources (IR‐HDRS), miniature electronic brachytherapy sources (eBT), and external electron beam radiation therapy (EEBRT). Although, all of these methodologies may deliver the desired radiation dose to the skin, but the dose to the underlying bone may become the limiting factor for selection of the optimum treatment technique. In this project, dose to the underlying bone has been evaluated as a function of the radiation type, thickness of the bone, and thickness of the soft tissue on top of bone, assuming the same radiation dose delivery to the skin. These evaluations are performed using Monte Carlo (MC) simulation technique with MCNP5 code. The results of these investigations indicate that, for delivery of the same skin dose with a 50 keV eBT, 4 MeV or 6 MeV EEBRT techniques, the average doses received by the underlying bones are 5.31, 2, or 1.75 times the dose received from IR‐HDRS technique, respectively. These investigations indicate that, for the treatment of skin cancer condition with bone immediately beneath skin, the eBT technique may not be the most suitable technique, as it may lead to excessive bone dose relative to IR‐HDRS and 6 MeV or 4 MeV electron beams.PACS number: 87.53.Jw, 87.55.K‐

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Optimum radiation source for radiation therapy of skin cancer

Safigholi

Song

Meigooni

2015

J Applied Clin Med Phys

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“…This source is used for fractionated treatments of breast and brain tumors in energy range of 30-50 keV (Dinsmore et al, 1996). Safigholi et al (2012), have published the Monte Carlo (MC) design and characterizations of the MEBXS with semi-hemisphere and conical tungsten anode shapes in homogenous water phantom based on AAPM TG-43U1 protocol. Most brachytherapy treatment planning systems (TPS) use TG-43U1 parameters for dose calculations.…”

Section: Introductionmentioning

confidence: 99%

Influences of spherical phantom heterogeneities on dosimetric charactristics of miniature electronic brachytherapy X-ray sources: Monte Carlo study

Jashni

Safigholi

Meigooni

2015

Applied Radiation and Isotopes

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“…The formalism has also been extended to generalized tungsten target EB sources. 34 For other EB systems, the output has been verified using a soft X-ray parallel plate ion chamber, in a liquid water tank or solid water phantom. This is the approach taken when INTRABEAM sources are calibrated in the factory, and also matches the usual approach for collimated kilovoltage units, where the dose is prescribed to the applicator end surface.…”

Section: Output Calibrationmentioning

confidence: 99%

Electronic brachytherapy—current status and future directions

Eaton¹

2015

BJR

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In the past decade, electronic brachytherapy (EB) has emerged as an attractive modality for the treatment of skin lesions and intraoperative partial breast irradiation, as well as finding wider applications in intracavitary and interstitial sites. These miniature X-ray sources, which operate at low kilovoltage energies (,100 kV), have reduced shielding requirements and inherent portability, therefore can be used outside the traditional realms of the radiotherapy department. However, steep dose gradients and increased sensitivity to inhomogeneities challenge accurate dosimetry. Secondly, ease of use does not mitigate the need for close involvement by medical physics experts and consultant oncologists. Finally, further studies are needed to relate the more heterogeneous dose distributions to clinical outcomes. With these provisos, the practical convenience of EB strongly suggests that it will become an established option for selected patients, not only in radiotherapy departments but also in a range of operating theatres and clinics around the world.

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Characteristics of miniature electronic brachytherapy x‐ray sources based on TG‐43U1 formalism using Monte Carlo simulation techniques

Cited by 17 publications

References 24 publications

Optimum radiation source for radiation therapy of skin cancer

Optimum radiation source for radiation therapy of skin cancer

Influences of spherical phantom heterogeneities on dosimetric charactristics of miniature electronic brachytherapy X-ray sources: Monte Carlo study

Electronic brachytherapy—current status and future directions

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