“…3 Lipid A is the main cause of toxicity of LPS, which makes LPS known as an endotoxin and can lead to fatal diseases such as septic shock, lung cancer, gastric cancer, etc. [4][5][6] According to the US Food and Drug Administration (FDA) guidelines, LPS in intraocular delivered gene therapy drugs should not exceed 0.5 EU per mL per eye (∼500 pg per mL per eye). 7 10 pg mL −1 of LPS is the cut-off value to distinguish between healthy individuals and Gramnegative bacteremia patients in a clinical setting.…”