Studying the topological organization of the cerebral blood flow fluctuations in resting state

Melie‐García, Lester; Sanabria‐Diaz, Gretel; Catasús, Carlos Sánchez

doi:10.1016/j.neuroimage.2012.08.082

Cited by 52 publications

(59 citation statements)

References 86 publications

(131 reference statements)

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“…More about the acquisition and reconstruction parameters, including corrections for attenuation and partial volume effect (PVE) due to atrophy, are described in our preceding article (Melie-García et al, 2013). A two-day protocol was used for CBF SPECT imaging at baseline (basal SPECT) and under the ACZ challenge (ACZ SPECT).…”

Section: Methodsmentioning

confidence: 99%

“…The acquisition protocol for volumetric MRI is described in details in our previous study (Melie-García et al, 2013). The preprocessing steps were as follows: images were segmented into GM and WM; imported into the DARTEL toolbox and normalized to MNI space to generate warped and smoothed (12 mm-kernel) Jacobian modulated GM and WM images.…”

Section: Methodsmentioning

confidence: 99%

“…For each group of subjects (MCI and control) in each condition (baseline and ACZ challenge), a CBF corr network was constructed as a CBF correlation matrix (Melie-García et al, 2013). In short, 90 ROIs were defined using the AAL atlas (Tzourio-Mazoyer et al, 2002) and Pearson's correlation coefficients were calculated (across subjects) between all possible pairs of ROIs.…”

Section: Methodsmentioning

confidence: 99%

“…We previously demonstrated that the cerebral blood flow correlation (CBF corr ) network, based on CBF SPECT data, shows a non-random topological organization (Melie-García et al, 2013). The same topological organization had been previously observed in sMRI correlation (Alexander-Bloch et al, 2013, for a review) and fiber tractography networks (Iturria-Medina et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach

Catasús

Sanabria‐Diaz

Willemsen

et al. 2017

NeuroImage: Clinical

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There is growing support that cerebrovascular reactivity (CVR) in response to a vasodilatory challenge, also defined as the cerebrovascular reserve, is reduced in Alzheimer's disease dementia. However, this is less clear in patients with mild cognitive impairment (MCI). The current standard analysis may not reflect subtle abnormalities in CVR. In this study, we aimed to investigate vasodilatory-induced changes in the topology of the cerebral blood flow correlation (CBFcorr) network to study possible network-related CVR abnormalities in MCI. For this purpose, four CBFcorr networks were constructed: two using CBF SPECT data at baseline and under the vasodilatory challenge of acetazolamide (ACZ), obtained from a group of 26 MCI patients; and two equivalent networks from a group of 26 matched cognitively normal controls. The mean strength of association (SA) and clustering coefficient (C) were used to evaluate ACZ-induced changes on the topology of CBFcorr networks. We found that cognitively normal adults and MCI patients show different patterns of C and SA changes. The observed differences included the medial prefrontal cortices and inferior parietal lobe, which represent areas involved in MCI's cognitive dysfunction. In contrast, no substantial differences were detected by standard CVR analysis. These results suggest that graph theoretical analysis of ACZ-induced changes in the topology of the CBFcorr networks allows the identification of subtle network-related CVR alterations in MCI, which couldn't be detected by the standard approach.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach

Catasús

Sanabria‐Diaz

Willemsen

et al. 2017

NeuroImage: Clinical

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“…Thereby, the CBF synchronous fluctuations in brain regions that form functional networks have allowed the investigation of resting brain networks (RBNs) and functional connectivity (FC) 3 . In this context, the arterial spin labeling (ASL) has emerged as an important tool, since it is a noninvasive magnetic resonance imaging (MRI) technique that can provide CBF maps.…”

Section: Introductionmentioning

confidence: 99%

Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging

Oliveira

Guimarães²,

Souza³

et al. 2017

Rev Bras Fis Med

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Networks of myelin covariance

Melie‐García

Slater

Ruef

et al. 2017

Human Brain Mapping

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Networks of anatomical covariance have been widely used to study connectivity patterns in both normal and pathological brains based on the concurrent changes of morphometric measures (i.e., cortical thickness) between brain structures across subjects (Evans, 2013). However, the existence of networks of microstructural changes within brain tissue has been largely unexplored so far. In this article, we studied in vivo the concurrent myelination processes among brain anatomical structures that gathered together emerge to form nonrandom networks. We name these “networks of myelin covariance” (Myelin‐Nets). The Myelin‐Nets were built from quantitative Magnetization Transfer data—an in‐vivo magnetic resonance imaging (MRI) marker of myelin content. The synchronicity of the variations in myelin content between anatomical regions was measured by computing the Pearson's correlation coefficient. We were especially interested in elucidating the effect of age on the topological organization of the Myelin‐Nets. We therefore selected two age groups: Young‐Age (20–31 years old) and Old‐Age (60–71 years old) and a pool of participants from 48 to 87 years old for a Myelin‐Nets aging trajectory study. We found that the topological organization of the Myelin‐Nets is strongly shaped by aging processes. The global myelin correlation strength, between homologous regions and locally in different brain lobes, showed a significant dependence on age. Interestingly, we also showed that the aging process modulates the resilience of the Myelin‐Nets to damage of principal network structures. In summary, this work sheds light on the organizational principles driving myelination and myelin degeneration in brain gray matter and how such patterns are modulated by aging.

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Studying the topological organization of the cerebral blood flow fluctuations in resting state

Cited by 52 publications

References 86 publications

Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach

Subtle alterations in cerebrovascular reactivity in mild cognitive impairment detected by graph theoretical analysis and not by the standard approach

Assessment of cerebral perfusional and functional connectivity in schizophrenia using magnetic resonance imaging

Networks of myelin covariance

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