Study the Hemoglobin Electrophoresis Patterns in two Populations from Salah - addin Province - Iraq

Abstract

The early identification of some clinically significant hemoglobinopathies and precise differentiation of hemoglobin variants are important to provide early comprehensive medical care to prevent some serious complications, assess prognosis and offer genetic counseling.
 This study examined the prevalence of α 2 - gene deletion in neonates in Samarra and Tikrit, Iraq. Screening study was carried out by examining fresh blood samples obtained from excised umbilical cord of 42 neonates born in neonates clinics in Samarra hospital and Tikrit hospital from October 2012 to March 2013. Hemoglobin electrophoresis were performed using Hellabio hemoglobin electrophoresis kit (He 10) and Hellabioscan system for detection of Hb bands and value % of fractions.
 The results showed 40 cases out of 42 (95.24%) have normal hemoglobin components. 2 cases out of 42 (4.76%) there was no visible band of HbA2 in hemoglobin electrophoresis pattern. Considering the missing of HbA2 band the two cases may have the deletion of δ gene so each one of them may has the genotype δ0/δ0.