Study the Expression of P53 Gene and Its Clinicopathological Correlation in Breast Cancer Cases.

Abstract

Context: Breast cancer is the most common cancer among women and second leading cause of cancer death worldwide. P53 is a tumor suppressor gene located on chromosome 17p13 with germ line mutations that convey a high risk for breast cancer. P53 is antiproliferative, helps in angiogenesis and causes programmed cell death but due to genotoxic stress or mutation, P53 loses its function thereby causing abnormal cell growth. To study the expression of P53 a tumor suppressor gene and its clinicopathologica Aim: Settings And l correlation in breast cancer cases. Designs: Material and methods: A Cross Sectional Study (Retrospective and Prospective). 50 cases of breast tumors studied over the period of 18 months from January 2021 to June 2022. Samples were received and reported in Department of Pathology, Gandhi Medical College Bhopal, Madhya Pradesh. A total of 50 cases of breast carcinoma were included in this Results: study predominated by inltrating ductal carcinoma (78%). High Immunohistochemistry expression of P53 was statistically signicant (p value <0.05) with age, tumor size, tumor grade, lymph node metastasis and ER receptor status whereas no correlation was found with stage of tumor. P53 functions as a negative regulator of cell Conclusion: growth. Breast cancer aggressiveness appears to be directly related to the percentage of p53 positive cancer cells and will help in determining prognosis.