Study the efficacy of herbal formulation Niśāmalakī in animal model of polycystic ovarian disease syndrome

Dawane, Jayshree; Pandit, Vijaya; Khade, Kapil Shatrughn; Suryawanshi, Sonali P; Wele, Asmita; Pawar, Madhuri; Bhalerao, Supriya

doi:10.4103/asl.asl_51_18

Cited by 4 publications

(6 citation statements)

References 2 publications

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“…With diabetic rats, the Nisha-amalaki therapy resulted in significant decreases in both fasting plasma glucose and glycated haemoglobin levels. Jayshree S Dawane, et.al 24 The study also demonstrated that four weeks of standardized Amalaki oral administration efficiently altered cholesterol levels by lowering low-density lipoprotein, total triglycerides, and total cholesterol while simultaneously increasing highdensity lipoprotein. In contrast, the placebo had no significant effect on the study variables.…”

Section: Antioxidant Propertymentioning

confidence: 86%

Role of Common Herbs- Curcuma Longa and Emblica Officinalis in Metabolic Disorders: A Narrative Review

Chhabra¹,

Kuchewar²,

Joshi³

2023

Int J Life Sci Pharm Res

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In the present era, Metabolic disorder is a challenge to the medical community because of its increasing prevalence and unsatisfactory management. There is no permanent remedy, and the patient has to continue the medicine for a longer life. According to Ayurveda, all metabolic diseases are caused due to Jathragnimandya(improper digestion & metabolism). Hence the correction of Agni is the principle to treat it. Various herbs act as agnivardhak (increase digestive fire or Rasayan (Rejuvenator). Haridra (Curcuma longa) and Amalaki (Emblica Officinalis) are the herbal drugs recommended in Ayurveda literature. Ayurveda practitioners are using these medicines for various metabolic disorders. Hence this review was carried out to discover their utility in metabolic disorders. The aim and objective of this review are to study the role of common herbs available worldwide, which are Haridra (Curcuma longa) and Amalaki (Emblicaofficinalis), in metabolic disorders. The related data were collected from classical texts of Ayurveda, google scholar, and PubMed. A total of 10 articles were considered for review. Out of these, four were animal studies, and six were analytical studies in which the assessment parameters were fasting. From this review, few studies have been conducted on only Haridra as compared to Amalaki on the post-meal blood sugar levels, glycolatedhaemoglobin (HbA1c) levels, oral glucose tolerance test, and complete blood count metabolic disorders. The maximum studies are on Nisha-Amalaki(a combination of Haridra&Amalakialongwith bhavna[trituration process] of Amalakiswarasa[Juice form of Emblicaofficinalis]to Haridra[Curcuma longa]) which is found to be effective in Diabetes mellitus and dyslipidemia, which can be considered as the cavity of previous reviews. Therefore, there is a need to conduct studies on Nisha-amalaki to explore its effect on other common metabolic disorders like PCOD, Hypothyroidism.

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Section: Antioxidant Propertymentioning

confidence: 86%

Role of Common Herbs- Curcuma Longa and Emblica Officinalis in Metabolic Disorders: A Narrative Review

Chhabra¹,

Kuchewar²,

Joshi³

2023

Int J Life Sci Pharm Res

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“…In rats, one cycle is of five days so the study was designed to cover four cycles and hence treatment was given for 28 days. 40 …”

Section: Methodsmentioning

confidence: 99%

Beneficial effect of polyherbal formulation in letrozole induced Polycystic ovarian syndrome (PCOS)

Prajapati

Patel²,

Dharamsi³

2022

Journal of Traditional and Complementary Medicine

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“…, Terminalia bellerica, Emblica officinalis, Zingiber officinale, Pipernigrum, Piper longum Linn. , Crataeva nurvala, Elettaria cardamomum, Cinnamomum zeylanicum, Commiphora mukul Wistar rats 100 mg/kg/day; 28 days Regularization of the estrous cycle ↓body weight, lipid profile, Blood glucose [ 68 ] Decoction Niśāmalakī Curcuma longa, Emblica officinalis Wistar rats 0.9 g/kg/day; 28 days Correction of changes induced by PCOS ↓body weight, lipid profile, Blood glucose [ 68 ] Decoction Sahoyao-gancao decoction Radix Paeoniae Alba. , Glycyrrhizae uralensis rats 12.5, 25,50 g/kg; 14 days Treatment of PCOS ↑IκB.…”

Section: The Promising Evidence Of Natural Products In Modern Drug Di...mentioning

confidence: 99%

“…Dawane et al showed that Niśāmalakī (NA) revised insulin resistance [ 68 ]. Kañcanāra Guggulu (KG) had less effect on insulin resistance, however, enhanced morphological changes were seen in all treatment groups.…”

Section: The Promising Evidence Of Natural Products In Modern Drug Di...mentioning

confidence: 99%

“…Serum sex hormone level is restored by the treatment of plant-derived compounds in many studies [ 48 , 49 , 53 , 54 , [57] , [58] , [59] , [60] , [61] , [63] , [64] , [65] , 67 , 69 ]. Histomorphology features of PCOS-induced rats' ovaries were improved by the compounds in eight studies [ 49 , 56 , 57 , 61 , 65 , 66 , 68 , 70 ]. In one study that analyzed two compounds, compounds respectively showed improved PCOS conditions but in combination they adversely affected PCOS [ 66 ].…”

Section: The Promising Evidence Of Natural Products In Modern Drug Di...mentioning

confidence: 99%

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Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

Jung,

Choi,

Kim

et al. 2023

Heliyon

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Study the efficacy of herbal formulation Niśāmalakī in animal model of polycystic ovarian disease syndrome

Cited by 4 publications

References 2 publications

Role of Common Herbs- Curcuma Longa and Emblica Officinalis in Metabolic Disorders: A Narrative Review

Role of Common Herbs- Curcuma Longa and Emblica Officinalis in Metabolic Disorders: A Narrative Review

Beneficial effect of polyherbal formulation in letrozole induced Polycystic ovarian syndrome (PCOS)

Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

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