Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

Jung, Woobin; Choi, Hyojoo; Kim, Jimin; Kim, Jeongwoo; Kim, Woojin; Nurkolis, Fahrul; Kim, Bonglee

doi:10.1016/j.heliyon.2023.e20889

Cited by 4 publications

(1 citation statement)

References 96 publications

(375 reference statements)

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“…Given the close linkage between inflammation and oxidative stress, elevated oxidative stress is usually involved in the development of inflammatory conditions ( 40 ). Furthermore, the hepatoprotective effects of natural sources in PCOS have been described in "Effects of natural products on PCOS: From traditional medicine to modern drug discovery" ( 58 ). In our study, P. anisum exhibited hepatoprotective properties in experimental PCOS model rats, significantly reducing oxidative stress and inflammation damage to the liver, possibly due to its ability to improve liver function ( 48 ).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Pimpinella anisum Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress

Dadkhah,

Gholizadeh,

Nasimi Doost Azgomi

et al. 2024

Iran J Pharm Res

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Background: Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disorder. Objectives: This study evaluated the therapeutic effects of Pimpinella anisum L. (P. anisum) fruit on pro-inflammatory cytokines, oxidative stress markers, and ovarian tissue structure in a rat model of PCOS. Methods: After inducing PCOS, female Wistar rats were randomly divided into control and PCOS groups. They orally received daily doses of normal saline or hydro-alcoholic extract of P. anisum at two doses (200 and 400 mg/kg) for 21 days. At the end of the treatment period, ovarian and liver tissues were collected to measure lipid peroxidation, antioxidant status, TNF-α, IL-6 mRNA expression, and its content. Additionally, histopathological examinations of the ovarian tissue were conducted. Results: Our findings revealed a dose-dependent change in the biochemical and histopathological parameters. Treatment with P. anisum resulted in a significant decrease in TNF-α and IL-6 mRNA expression levels and their content in the ovarian and liver tissues. It also reduced MDA levels while increasing SOD and GPx activity in both ovarian and liver tissues of PCOS rats. Furthermore, the number of follicular cysts in the PCOS rat model was significantly reduced. Conclusions: The beneficial effects of P. anisum in PCOS rats are partly attributed to the inhibition of inflammatory and oxidative stress markers in ovarian tissue. These findings suggest that P. anisum could be a potential candidate for the treatment of PCOS disorders

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Pimpinella anisum Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress

Dadkhah,

Gholizadeh,

Nasimi Doost Azgomi

et al. 2024

Iran J Pharm Res

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Zhibai dihuang pill (ZBDH) exhibits therapeutic effects on idiopathic central sexual precocity in rats by modulating the gut microflora

Yi,

Zou,

Lin

et al. 2024

Heliyon

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Polycystic ovary syndrome and its management: In view of oxidative stress

Bhattacharya,

Dey,

Sen

et al. 2024

Biomolecular Concepts

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In the past two decades, oxidative stress (OS) has drawn a lot of interest due to the revelation that individuals with many persistent disorders including diabetes, polycystic ovarian syndrome (PCOS), cardiovascular, and other disorders often have aberrant oxidation statuses. OS has a close interplay with PCOS features such as insulin resistance, hyperandrogenism, and chronic inflammation; there is a belief that OS might contribute to the development of PCOS. PCOS is currently recognized as not only one of the most prevalent endocrine disorders but also a significant contributor to female infertility, affecting a considerable proportion of women globally. Therefore, the understanding of the relationship between OS and PCOS is crucial to the development of therapeutic and preventive strategies for PCOS. Moreover, the mechanistic study of intracellular reactive oxygen species/ reactive nitrogen species formation and its possible interaction with women’s reproductive health is required, which includes complex enzymatic and non-enzymatic antioxidant systems. Apart from that, our current review includes possible regulation of the pathogenesis of OS. A change in lifestyle, including physical activity, various supplements that boost antioxidant levels, particularly vitamins, and the usage of medicinal herbs, is thought to be the best way to combat this occurrence of OS and improve the pathophysiologic conditions associated with PCOS.

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Effects of natural products on polycystic ovary syndrome: From traditional medicine to modern drug discovery

Cited by 4 publications

References 96 publications

Therapeutic Effects of Pimpinella anisum Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress

Therapeutic Effects of Pimpinella anisum Fruit Extract on Polycystic Ovary Syndrome in a Rat Model: Emerging Role of Inflammatory Responses and Oxidative Stress

Zhibai dihuang pill (ZBDH) exhibits therapeutic effects on idiopathic central sexual precocity in rats by modulating the gut microflora

Polycystic ovary syndrome and its management: In view of oxidative stress

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