Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. The HIPERPROT-GER study

Malafarina, Vincenzo; Úriz-Otano, Francisco; Gil-Guerrero, Lucía; Iniesta, Raquel; Zulet, M. Ángeles; Martínéz, J. Alfredo

doi:10.1016/j.maturitas.2013.06.016

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…Multidisciplinary nutritional care reduced nutritional deterioration during admission (5.4 vs. 20.5 %; p = 0.049), and increased the rate of discharge directly back to the community (48.0 vs. 17.6 %; p = 0.012) in a pragmatic intervention study [ 53 ]. A high-protein nutritional intervention-based study on β-hydroxy-β-methylbutyrate, vitamin D3, and calcium in obese and lean aged patients with hip fractures and sarcopenia will be implemented [ 54 ]. These results indicate that nutrition support for hip fracture patients may improve nutrition status and rehabilitation outcome.…”

Section: Hip Fracturementioning

confidence: 99%

Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management

Wakabayashi

Sakuma

2014

J cachexia sarcopenia muscle

291

215

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Malnutrition and sarcopenia often occur in rehabilitation settings. The prevalence of malnutrition and sarcopenia in older patients undergoing rehabilitation is 49–67 % and 40–46.5 %, respectively. Malnutrition and sarcopenia are associated with poorer rehabilitation outcome and physical function. Therefore, a combination of both rehabilitation and nutrition care management may improve outcome in disabled elderly with malnutrition and sarcopenia. The concept of rehabilitation nutrition as a combination of both rehabilitation and nutrition care management and the International Classification of Functioning, Disability and Health guidelines are used to evaluate nutrition status and to maximize functionality in the elderly and other people with disability. Assessment of the multifactorial causes of primary and secondary sarcopenia is important because rehabilitation nutrition for sarcopenia differs depending on its etiology. Treatment of age-related sarcopenia should include resistance training and dietary supplements of amino acids. Therapy for activity-related sarcopenia includes reduced bed rest time and early mobilization and physical activity. Treatment for disease-related sarcopenia requires therapies for advanced organ failure, inflammatory disease, malignancy, or endocrine disease, while therapy for nutrition-related sarcopenia involves appropriate nutrition management to increase muscle mass. Because primary and secondary sarcopenia often coexist in people with disability, the concept of rehabilitation nutrition is useful for their treatment. Stroke, hip fracture, and hospital-associated deconditioning are major causes of disability, and inpatients of rehabilitation facilities often have malnutrition and sarcopenia. We review the concept of rehabilitation nutrition, the rehabilitation nutrition options for stroke, hip fracture, hospital-associated deconditioning, sarcopenic dysphagia, and then evaluate the amount of research interest in rehabilitation nutrition.

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Section: Hip Fracturementioning

confidence: 99%

Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management

Wakabayashi

Sakuma

2014

J cachexia sarcopenia muscle

291

215

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“…Both muscle and bone strength are of utmost importance in orthopedic surgery patients. Loss of muscle strength is a risk factor for fall related injuries [16]. Patients with hip fractures are usually elderly individuals with an acute fracture.…”

Section: Discussionmentioning

confidence: 99%

Improved Nutrition Status is Associated with Attenuated Decrease in Circulating Myostatin After Hip Fracture Surgery in Elderly Patients

Åkerfeldt,

Adinda,

Gunnarsson

et al. 2020

OAJGGM

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Aim: Myostatin is a potent regulator of muscle growth as well as bone regeneration. The aim of this study was to investigate the effect of orthopedic surgery on myostatin levels in a nutritional intervention study. Materials and Methods: Patients with hip fractures treated at the Uppsala University Hospital were enrolled in the study. Additional nutrition was given to an intervention group (n=46) while a control group were given standard nutrition (n=42). The additional support was provided in the form of two preoperative carbohydrate drinks, an intravenous glucose infusion preoperatively, and drinks three times a day during the first five postoperative days. Results: 88 patients completed the study. Compared to preoperative values (median 2338 pg/mL, interquartile range 1258-3905 pg/mL) there were significant decreases in myostatin values after surgery (median 1471 pg/mL, interquartile range 783-2273 pg/mL); p<0.000001). The decrease from preoperative to postoperative values was smaller in the intervention group (p=0.020). Conclusions: There is a highly significant decrease in myostatin values after orthopedic surgery. Increased nutritional support significantly attenuated the decrease..

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“…В рандомизированном двойном слепом проспективном контролируемом исследовании (R. Anbar и соавт., 2014) ПЭП под контролем диетолога и лечащего врача улучшало клинические показатели пациентов после операций на тазобедренном суставе [59]. Комплексное высокобелковое высокоэнергетическое ПЭП, дополненное витамином D 3 , улучшало НС и клинические показатели у лиц с саркопенией в процессе реабилитации после перенесенных переломов шейки бедра (V. Malafarina и соавт., 2013) [60]. Эти данные свидетельствуют о целесообразности назначения сбалансированного ПЭП в фазе реабилитации пожилых лиц с НН и саркопенией в травматологии и ортопедии.…”

Section: заболевания опорно-двигательного аппаратаunclassified

Sip feeding as a type of nutritional and metabolic support in clinical medicine

et al. 2020

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The article provides an analytical review of the use of oral enteral nutrition (OEN, or sip feeding) as an adjuvant therapy and nutritional and metabolic support in various diseases and pathological conditions. Liquid and powdery sip feeds are currently becoming increasingly widespread due to their physiological nature and effectiveness in maintaining a nutritional status and eliminating nutritional deficiency in patients from different fields of medicine: oncology, musculoskeletal disorders, cardiovascular and pulmonary diseases (chronic obstructive pulmonary disease) and others. These sip mixtures contain proteins, fats, carbohydrates (macronutrients), omega-3 polyunsaturated fatty acids, as well as vitamins and minerals. Sip feeding is a supplement to a regular diet and is given between meals. The most prevalent sip feeding scheme is taking liquid forms of sip feeds in volumes of 200300 ml 23 times a day. Regimes which combine a regular diet and OEN should provide target indicators of energy and protein consumption: 2530 kcal/kg per day and 1.41.8 g of protein per 1 kg of body weight per day. In extremely severe cases, protein intake may be increased. Calorie ratio for individual nutrients in total energy consumption: proteins/fats/carbohydrates 20/30/50%. Sip feeding improves clinical and financial outcomes in inpatient and outpatient practice: shortens the time of staying in the clinic; reduces the number of infectious and non-infectious complications, the rate of repeated hospitalizations; treatment costs; improves the quality of life. OEN is recommended by the European Society for Clinical Nutrition and Metabolism guidelines and by many national guidelines on enteral nutritional support.

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Study protocol: High-protein nutritional intervention based on β-hydroxy-β-methylbutirate, vitamin D3 and calcium on obese and lean aged patients with hip fractures and sarcopenia. The HIPERPROT-GER study

Cited by 10 publications

References 44 publications

Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management

Rehabilitation nutrition for sarcopenia with disability: a combination of both rehabilitation and nutrition care management

Improved Nutrition Status is Associated with Attenuated Decrease in Circulating Myostatin After Hip Fracture Surgery in Elderly Patients

Sip feeding as a type of nutritional and metabolic support in clinical medicine

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