Study on Toxicity of Oreochromis Niloticus with Aflatoxinb1

Sherif, Ahmed H.; Abdel-Maksoud, S. A.; Shukry, M. M.

doi:10.12816/0011065

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The obtained data were consistent with Ref. (El-Boshy et al, 2008;Sherif et al, 2013) and (Hussain et al, 2017), who reported the occurrence of anaemia in aflatoxin-supplemented fish, attributed that to the toxic effect of aflatoxin to the kidney of O. niloticus fish (Stoskopf, 1993). In the same context, (Roberts, 2001) This study clearly demonstrated that the key leucocytic image of acute stress of teleost fish is neutrophilia and lymphopenia., Sherif et al showed that fish exposed to aflatoxin showed significant leucocytosis.…”

Section: Discussionsupporting

confidence: 91%

“…Our result revealed improvement in body weight gain and decreased mortality % either pre‐ and post challenged with A. hydrophila with or without AFB1 supplementation, in which AFB1 lead to an rise in the mortality % and decline in the body weight, the obtained result was in harmony with Ref. (Jakić‐Dimić et al, 2005; Sherif et al, 2013), which revealed that O. niloticus fed on high AFB1 diet has pathological lesion and increased the mortality %. However, Nya and Austin (2010) proved that there were rises in specific growth rate (SGR), feed conversion ratio (FCR) and protein efficiency ratio (PER) in LPS‐treated fish.…”

Section: Discussionsupporting

confidence: 87%

“…Dawood et al, (2018) reported the immunostimulant activity of LPS. The immune system can be induced by inactive natural or microbial products including β glucans, lipopolysaccharides, chitin, fucoidane and peptidoglycans (NRC, 2011).Our result revealed improvement in body weight gain and decreased mortality % either pre-and post challenged with A. hydrophila with or without AFB1 supplementation, in which AFB1 lead to an rise in the mortality % and decline in the body weight, the obtained result was in harmony with Ref (Jakić-Dimić et al, 2005;Sherif et al, 2013),. which revealed that O. niloticus fed on high AFB1 diet has pathological lesion and increased the mortality %.…”

supporting

confidence: 77%

See 2 more Smart Citations

Ameliorative effect of dietary lipopolysaccharides on Oreochromis niloticus juveniles submitted to aflatoxin B1‐induced oxidative stress and bacterial challenge

El‐Kader¹,

Shukry

Dawood³

et al. 2021

Aquaculture Research

View full text Add to dashboard Cite

The current study was designed to evaluate the ameliorative effect of lipopolysaccharides (LPS) (a portion of the Gram -ve bacteria cell wall) on aflatoxin (AFB1)-persuaded changes in the cytokine expression, heat-shock protein 70 (HSP70), antioxidant genes, different haematological and biochemical parameters in Nile Tilapia along with the infection by Aeromonas hydrophila and the immune-stimulant efficiency of LPS on the growth pattern. For this study, two hundred and forty O. niloticus (35 ± 1.5 g) were used. The fish were randomly allocated into four experimental groups, four replicates for each group (15 fish/replicate). Group 1 was the negative control group fed on a basal diet, and group 2 was the positive control group fed on the basal diet with aflatoxins (AFB1) 200 µg/kg feed. Group 3 has fed the lipopolysaccharides 20 mg/100 gm diets. Group 4, besides the AFB1-contaminated basal diet, was provided with lipopolysaccharides 20 mg/100 gm diet. At the end of the 12 weeks, each group was injected with A. hydrophila. The analysis revealed that LPS-treated AFB1supplemented fish showed improvement in haematological, lysosomal and phagocytic activities and total protein and significantly decreased liver enzyme exaggerated by aflatoxin; alongside, the LPS-treated aflatoxin-supplemented fish revealed a significant effect on the haematological and the immunity markers after 24 h, 48 h and 1 week post challenged with A. hydrophila. Concerning the gene expression, AFB1 group showed significant up-regulation of HSP70 and interferon gamma gene mRNA expression, which is significantly down-regulated by LPS treatment, besides LPS showed up-regulation of catalase and superoxide dismutase genes markedly alongside with interleukins (IL), IL-8 and IL-1B; the binding effect of LPS markedly appears after A. hydrophila which significantly modulates the HSP70 and immunity marker genes in addition to the antioxidant-related genes, CAT and SOD. Histopathological findings reflected a marked increase in intestinal villi length in LPS-treated groups.Our view illuminates for the first time the pathways of molecular wellness for the role of LPS in AFB1 toxicity and bacterial infection. Our observation illuminates the | 3661 ABD EL-KADER Et AL.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 87%

supporting

confidence: 77%

See 1 more Smart Citation

Ameliorative effect of dietary lipopolysaccharides on Oreochromis niloticus juveniles submitted to aflatoxin B1‐induced oxidative stress and bacterial challenge

El‐Kader¹,

Shukry

Dawood³

et al. 2021

Aquaculture Research

View full text Add to dashboard Cite

show abstract

“…The recorded results showed that birds treated with Synertox ® showed non-significant alterations in serum ALT and AST activities at 1 st day posttreatment. These findings are relatively similar with Sherif et al, (44) who reported that fish treated with Synertox ® revealed no marked alterations in ALT and AST levels compared with the control group. On the other hand, Synertox ® revealed a marked elevation in the levels of serum AST and ALT at 7 th day post-treatment.…”

Section: Efficacy Of T-nil Plus® and Synertox® On Chickensupporting

confidence: 91%

Pharmacological effect of T-NilPlus® and Synertox®, commercial anti-mycotoxins, on broiler chickens in Egypt

et al. 2022

View full text Add to dashboard Cite

The present study was carried out to investigate the potential ameliorative effect of two commercial anti-mycotoxins, containing Saccharomyces cerevisiae cell wall as prebiotic (T-Nil Plus®) and Bacillus subtilis as probiotic (Synertox®) on performance and some biochemical parameters of broilers. One hundred and twenty chicks one day old chicks were divided into 3 equal groups. 1st group was served as control, 2nd group was given T-Nil Plus®. The 3rd group was given Synertox®. Chicken’s performance was estimated. Serum samples obtained from each group for biochemical analysis. Tissues samples were collected for histopathological examination. The obtained results revealed that, T-Nil plus® induced a marked reduction in body weight gain and an elevation in Feed consumption, moreover, a marked elevation in, alanine aminotransferase (ALT), creatinine and malondialdehyde (MDA) and a marked reduction in aspartate aminotransferase (AST) was detected. While Synertox® caused a significant decrease in body weight, body weight gain and no change in feed conversion rate (FCR) and a marked elevation in ALT, creatinine and a marked reduction in AST and nitric oxide (NO) and it caused a significant reduction in serum glucose level of the birds. In conclusion, Synertox® induced a powerful effect comparing to T-Nil Plus®, as it induces a good FCR and increases the response of the birds against oxidative stress.

show abstract

“…induces systematic diseases with higher death rates in fish (Lone & Beigh, 2014;Mahfouz, Moustafa, Kassab & Marzouk, 2019;. Also, A. flavus and A. ochraceous are mycotoxin-producing fungi (Hashem, 2011) which produce aflatoxins B1 (AFB1) that cause potential hazards for fish such as immunosuppression, decrease in growth performance, increase susceptibility to disease and higher mortality (Abdel Rahman, Abdellatief & Mahboub, ;Ahmed et al, 2022;Marijani;, Kigadye & Okoth, 2019;Santacroce et al, 2008;Sherif, Abdel-Maksoud & Shukry, 2013). Also, AFB1 accumulates in fish flesh and organs inducing human poisoning, liver tumours and even death resulted from their consumption (Shephard, 2008).…”

mentioning

confidence: 99%

Detection, diagnosis, Koch’s postulate, hepatorenal and antioxidant indicators for some systemic pathogenic fungi invading the liver and kidneys of African catfish ( Clarias gariepinus ) in Egypt with a histopathological approach

Mahboub

Nada

Abdel‐Ghany

et al. 2022

Aquaculture Research

View full text Add to dashboard Cite

Recently, systemic fungal infections have emerged as significant causes of fish morbidity and mortality. Hence, the current study investigates the occurrence of some pathogenic systemic fungi inducing severe lesions in the liver and kidneys of African catfish. Two hundred diseased African catfish were collected from private fish farms in Egypt, and only 120 fish were infected with 212 different fungal isolates at a rate of 60%. The seasonal survey revealed isolation of 72 isolates of yeast (Candida albicans) and 140 isolates of moulds including non‐pigmented moulds, Aspergillus ochraceous and Aspergillus flavus, as well as pigmented mould (Cladosporium herbarum). The isolated fungi induced characteristic post‐mortem lesions. To date, this is the first report for isolation of C. herbarum and C. parapsilosis from Nile catfish liver and kidneys. Various techniques were performed to identify the fungi including gross observation, microscopic examination of tissue squashes, in vitro culture and histopathology. Koch's postulate was fulfilled to confirm the fungal pathogenicity. The challenged fungi altered the hepatorenal indicators (ALP, AST, ALT, urea and creatinine) and oxidative stress biomarkers (MDA, CAT and SOD). The results indicate the virulence of the isolated fungi, and future studies are needed for treatment trials.

show abstract

Study on Toxicity of Oreochromis Niloticus with Aflatoxinb1

Cited by 6 publications

References 0 publications

Ameliorative effect of dietary lipopolysaccharides on Oreochromis niloticus juveniles submitted to aflatoxin B1‐induced oxidative stress and bacterial challenge

Ameliorative effect of dietary lipopolysaccharides on Oreochromis niloticus juveniles submitted to aflatoxin B1‐induced oxidative stress and bacterial challenge

Pharmacological effect of T-NilPlus® and Synertox®, commercial anti-mycotoxins, on broiler chickens in Egypt

Detection, diagnosis, Koch’s postulate, hepatorenal and antioxidant indicators for some systemic pathogenic fungi invading the liver and kidneys of African catfish ( Clarias gariepinus ) in Egypt with a histopathological approach

Contact Info

Product

Resources

About