“…The plasmon-induced EM enhancement of these metal nanocrystals is significantly influenced by their shape, size, and morphology. − Many types of metal structures have been synthesized to facilitate efficient SERS detection, encompassing nanosphere, nanorods, nanotriangles, nanowire, and so on. − However, the high EM field intensity of these metal nanocrystals is predominantly located at the high-curvature surface due to the lightning rod effect; many flat surfaces on this structure have limited EM enhancement under light excitation, thereby leading to low SERS efficiency. Many efficient means have been proposed to optimize the EM enhancement of metal structures, including the growth of metal nanoparticles with rough surface, − the fabrication of branched gold nanostars, − and the construction of multilayered and hollow structures. , These approaches offer valuable insights for the design of metal nanocrystals with substantial EM enhancement and enhanced SERS sensitivity. Beyond the pursuit of ultrahigh SERS sensitivity, the signal reproducibility of the metal substrate is equally critical in SERS applications.…”