Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte

Cheng, Lan; Wang, Tingting; Gao, Z C; Wu, Wenkai; Cao, Yezhi; Wang, Linghu; Zhang, Qi

doi:10.1248/bpb.b21-00965

Cited by 3 publications

(4 citation statements)

References 61 publications

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“…APAP overdose trigger the activation of pro-inflammatory factors [ 14 , 15 ]. The L-O2 cells were treated with a previously （2.2.2）described method, the levels of IL-6 and TNF- α were detected in L-O2 cells induced by APAP, according to the manufacturer's instructions at absorbance 450 nm and reference 630 nm.…”

Section: Methodsmentioning

confidence: 99%

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Zhou

Xia

et al. 2023

Heliyon

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Section: Methodsmentioning

confidence: 99%

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Zhou

Xia

et al. 2023

Heliyon

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“…However, there are challenges in clinical applications due to their poor water solubility and low oral bioavailability. Sch B reduces the expression of ROS and inflammatory cytokines in liver cells, activates the pentose phosphate pathway, and inhibits the MAPK, JNK, and ERK signaling pathways, thus exerting antioxidant, anti-inflammatory, and anti-apoptotic effects [67]. SC decreases the expression of CYP2E1, inhibits cell apoptosis, improves inflammatory responses, and activates the Nrf2 signaling pathway, thereby inhibiting oxidative stress and alleviating APAP-induced liver injury [68].…”

Section: Metabolic Pathwaysmentioning

confidence: 99%

“…antioxidant, anti-inflammatory, and anti-apoptotic effects [67]. SC decreases the expression of CYP2E1, inhibits cell apoptosis, improves inflammatory responses, and activates the Nrf2 signaling pathway, thereby inhibiting oxidative stress and alleviating APAP-induced liver injury [68].…”

Section: Metabolic Pathwaysmentioning

confidence: 99%

Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review

Li,

Lao,

Lei

et al. 2023

Molecules

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The liver plays a vital role in metabolism, synthesis, and detoxification, but it is susceptible to damage from various factors such as viral infections, drug reactions, excessive alcohol consumption, and autoimmune diseases. This susceptibility is particularly problematic for patients requiring medication, as drug-induced liver injury often leads to underestimation, misdiagnosis, and difficulties in treatment. Acetaminophen (APAP) is a widely used and safe drug in therapeutic doses but can cause liver toxicity when taken in excessive amounts. This study aimed to investigate the hepatotoxicity of APAP and explore potential treatment strategies using a mouse model of APAP-induced liver injury. The study involved the evaluation of various natural products for their therapeutic potential. The findings revealed that natural products demonstrated promising hepatoprotective effects, potentially alleviating liver damage and improving liver function through various mechanisms such as oxidative stress and inflammation, which cause changes in signaling pathways. These results underscore the importance of exploring novel treatment options for drug-induced liver injury, suggesting that further research in this area could lead to the development of effective preventive and therapeutic interventions, ultimately benefiting patients with liver injury caused by medicine.

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“…It was reported that three main types of drugs causing DILI in China were traditional Chinese medicine and anti-tuberculosis (anti-TB) drugs. [1][2][3] Isoniazid (INH) and rifampicin (RFP) are the first-line anti-TB drugs, which are often used in combination to produce synergistic effect and reduce drug resistance.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice

Jiao

Bao

et al. 2022

Chem. Pharm. Bull.

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The protective effect of phloridzin (PHL) and its potential mechanism were examined in mice with liver injury induced by isoniazid (INH) and rifampicin (RFP). The mice were randomly divided into normal control group, model group, low (80 mg/kg), medium (160 mg/kg) and high (320 mg/kg) phloridzin-treated groups. After 28 days treatment, blood and liver tissue were collected and analysed. The results revealed that PHL regulated liver function related indicators and reduced the pathological tissue damage, indicating that PHL significantly alleviated the liver injury. Furthermore, the level of cytochrome P450 (CYP450) enzyme, the expression of cytochrome P450 3A4 (CYP3A4), cytochrome P450 2E1 (CYP2E1), heme oxygenase-1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) mRNA and protein were inhibited by PHL.These results indicated that PHL exerts a protecting effect against liver injury induced by combination of RFP and INH. The potential mechanisms may be concerned with the activation of Nrf2/HO-1 signaling pathway containing its key antioxidant enzymes and regulation of CYP3A4 and CYP2E1.

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Study on the Protective Effect of Schizandrin B against Acetaminophen-Induced Cytotoxicity in Human Hepatocyte

Cited by 3 publications

References 61 publications

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Swertiamarin or heat-transformed products alleviated APAP-induced hepatotoxicity via modulation of apoptotic and Nrf-2/NF-κB pathways

Natural Products for Acetaminophen-Induced Acute Liver Injury: A Review

Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice

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