Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice

Jiao, Yang; Li, Guorong; Bao, Xiaoai; Suo, Yujie; Xu, Hailong; Deng, Ying; Feng, Tao; Deng, Gai-Gai

doi:10.1248/cpb.c22-00466

Cited by 7 publications

(2 citation statements)

References 32 publications

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“…However, rifampicin induces liver mitochondrial enzymes that reduce serum cyclosporin A levels and may therefore aggravate GVHD ( Wasko et al., 2017 ). In addition, rifampicin was more likely to have adverse reactions when there was liver disease or when it was combined with isoniazid ( Yang et al., 2022 ). Considering the long-term use of tacrolimus for anti-rejection, chronic GVHD and poor liver and kidney functions, rifampicin was not administered, although sensitive to rifampicin.…”

Section: Discussionmentioning

confidence: 99%

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

Li,

Yu,

Jiang

et al. 2023

Front. Cell. Infect. Microbiol.

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BackgroundTuberculosis (TB) is a rare but potentially devastating complication in hematopoietic stem cell transplantation (HSCT) recipients. Myelosuppression-related antibiotics should be used cautiously in patients with hematological malignancies, especially those undergoing bone marrow transplantation and receiving bone marrow suppression therapy. Although linezolid has become the recommended drug for severe TB, its hematological toxicity is still an obstacle to its clinical application. Contezolid is a new representative of oxazolidinones in clinical development, showing superior anti-infection efficacy, but there have been no reports on the treatment of post-HSCT TB.Case presentationWe reported a patient with acute lymphoblastic leukemia suffered from pulmonary TB infection after HSCT. During anti-TB treatment, the patient had a poor response to linezolid-containing regimen, and developed side effects such as gingival bleeding and thrombocytopenia, so the administration was switched to contezolid. After 15 days of continuous treatment, the patient’s platelet increased to 58×109/L, and he was discharged in stable condition. During subsequent anti-TB treatment with contezolid for more than 7 months, the platelets remained stable, and no hematological adverse reactions and no symptoms of peripheral neuropathy were observed. Moreover, repeat imaging showed that the bilateral lung lesions were significantly reduced, indicating a good outcome for the patient.ConclusionThis was the first successful case of post-HSCT TB patients treated with contezolid-containing antibiotic management strategies, which exhibited remarkable efficacy and good safety in this deadly disease.

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Section: Discussionmentioning

confidence: 99%

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

Li,

Yu,

Jiang

et al. 2023

Front. Cell. Infect. Microbiol.

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“…Although it has been shown that some drugs (such as Naringenin, Phloridzin) have a therapeutic effect on INH+RIF-induced liver injury [ 7 , 8 ], clinically, the treatment of liver injury caused by INH+RIF is still inconclusive. Many compounds in natural plants have been found to be effective in treating various diseases [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing

Li,

Yang,

Cao

et al. 2023

Molecules

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Bergenin (BER), a natural component of polyphenols, has a variety of pharmacological activities, especially in improving drug metabolism, reducing cholestasis, anti-oxidative stress and inhibiting inflammatory responses. The aim of this study was to investigate the effects of BER on liver injury induced by isonicotinic acid hydrazide (INH) and rifampicin (RIF) in mice. The mice model of liver injury was established with INH (100 mg/kg)+RIF (100 mg/kg), and then different doses of BER were used to intervene. The pathological morphology and biochemical indicators of mice were detected. Meanwhile, RNA sequencing was performed to screen the differentially expressed genes and signaling pathways. Finally, critical differentially expressed genes were verified by qRT-PCR and Western blot. RNA sequencing results showed that 707 genes were significantly changed in the INH+RIF group compared with the Control group, and 496 genes were significantly changed after the BER intervention. These differentially expressed genes were mainly enriched in the drug metabolism, bile acid metabolism, Nrf2 pathway and TLR4 pathway. The validation results of qRT-PCR and Western blot were consistent with the RNA sequencing. Therefore, BER alleviated INH+RIF-induced liver injury in mice. The mechanism of BER improving INH+RIF-induced liver injury was related to regulating drug metabolism enzymes, bile acid metabolism, Nrf2 pathway and TLR4 pathway.

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Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

Quintero-Rincón,

Pájaro-González,

Diaz-Castillo

2024

ADV TRADIT MED (ADTM)

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Maclura tinctoria (Moraceae), commonly known as dinde, is a lactescent tree of significant economic importance with extensive ethnomedicinal and ethnobotanical applications. Among native populations in the Neotropics, dinde is used to address diverse forms of inflammatory arthritis, along with ailments stemming from viral, bacterial, or fungal origins. Its efficacy stands out notably in the treatment of conditions affecting the buccal cavity, respiratory tract, and venereal infections. These medicinal attributes have spurred investigations into their potential for developing nutraceuticals and pharmacological agents. Also, dinde has a commercial appeal intertwined with the remarkable qualities of its wood, which include the resistance to moisture and termites. This review consolidates information encompassing peer-reviewed articles from major scientific databases such as Science Direct, Scopus, Springer, PubMed, and Google Scholar. The review spans fifty-four phytocompounds, characterized by remarkable structural complexity and identified from the year 2000 onward. These compounds are categorized into flavones, isoflavones, flavonols, flavanols, flavanones, chalcones, and xanthones, where a significant portion exhibiting glycosylation or prenylation. Additionally, phenolic acids and condensed tannins contribute to the chemical diversity of this species. This comprehensive review offers updated insights into the potential bioactivity of chemical constituents identified in this plant, elucidating findings derived from different studies employing both in vitro and in vivo assays. Graphical abstract

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Hepatoprotective Effects of Phloridzin against Isoniazid-Rifampicin Induced Liver Injury by Regulating CYP450 and Nrf2/HO-1 Pathway in Mice

Cited by 7 publications

References 32 publications

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

Rare tuberculosis in recipients of allogeneic hematopoietic stem cell transplantation successfully treated with contezolid–a typical case report and literature review

The Effect of Bergenin on Isonicotinic Acid Hydrazide and Rifampicin-Induced Liver Injury Revealed by RNA Sequencing

Maclura tinctoria (L.) D. Don ex Steud. (Moraceae): a review of the advances in ethnobotanical knowledge, phytochemical composition, and pharmacological potential

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