Study on the process of simultaneous oxidation of acyl chloride of novel insecticide tetrachlorantraniliprole using in situ FTIR

Abstract

The novel insecticide tetrachlorantraniliprole was synthesized utilizing 2,3,5-trichloropyridine as the starting material by a six-step route in 18% yield. The process of simultaneous oxidation and acyl chlorination was studied by in situ FTIR. The molecular structure of tetrachlorantraniliprole was identified by means of NMR, IR, MS, and X-ray diffraction analyses. The single crystal of tetrachlorantraniliprole was formed from toluene solvent, and exhibited monoclinic P2 1 /n group with crystal parameters of a = 15.3316(16) Å, b = 16.7139(16) Å, c = 19.6687(19) Å, V = 4835.2(8) Å 3 , and Z = 4. Moreover, its density = 1.605 g/m 3 , F(000) = 2328.0, µ = 2.17 mm −1 , and 26933 reflections were measured (2.992° 2θ 51.998°).

Preparation of a broad-specific monoclonal antibody and development of an immunochromatographic assay for monitoring of anthranilic diamides in vegetables and fruits

“…18 TEA possessed low acute oral and dermal toxicities toward rats, as well as low or no effects on non-target organisms. 4,19 Currently, TEA is widely used in China for control of Lepidoptera on crops. Therefore, the MRL for TEA in China is set at 0.05-3 mg kg −1 in cereals and vegetables.…”