Study on the new bone cement based on calcium sulfate and Mg, CO3 doped hydroxyapatite

Zima, Aneta; Paszkiewicz, Z.; Siek, D.; Czechowska, Joanna; Ślósarczyk, A.

doi:10.1016/j.ceramint.2012.02.086

Cited by 35 publications

(24 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the advances in biology and materials science at the molecular level, it has become possible to add a number of features to orthopedic implants for obtaining better results. Various forms of HA were recently doped with many ions separately or in combination to serve different functions, such as bone growth enhancer, anti‐osteoporotic, antibacterial, and less commonly anticancer therapeutic . In this study, Se was chosen as the dopant element as it is a potential cancer preventive and inhibitory agent and has antibacterial effect on S. epidermidis…”

Section: Discussionmentioning

confidence: 99%

Surface Characterization and Biocompatibility of Selenium‐Doped Hydroxyapatite Coating on Titanium Alloy

Yılmaz

Evis

Tezcaner

et al. 2016

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

Selenium‐doped hydroxyapatite (HA) was biomimetically coated on Ti6Al4V plates with the aim of combining the anticancer and antibacterial properties of selenium with the biocompatibility and bioactivity of HA. For the coating process, the composition of 1.5 × SBF (solution with ion concentrations at 1.5 times that of simulated body fluid, SBF) was modified to include 0.15 mM selenate (SeO42−) ion. The selenium‐doped HA coating was characterized by several methods, such as scanning electron microscopy, X‐ray diffraction, and Fourier transform infrared spectroscopy. The cytotoxicity of selenium on osteoblast and osteosarcoma cells was determined. The coating was shown to inhibit the growth of Staphylococcus epidermidis.

show abstract

Section: Discussionmentioning

confidence: 99%

Surface Characterization and Biocompatibility of Selenium‐Doped Hydroxyapatite Coating on Titanium Alloy

Yılmaz

Evis

Tezcaner

et al. 2016

Int J Applied Ceramic Tech

View full text Add to dashboard Cite

show abstract

“…The list of possible additives includes (but is not limited to) the following cations: Na + , K + , Mg 2+ , Ca 2+ , Sr 2+ , Zn 2+ , H + and anions: PO 4 3− , HPO 4 2− , H 2 PO 4 − , P 2 O 7 4− , CO 3 2− , HCO 3 − , SO 4 2− , HSO 4 − , Cl − , OH − , F − , silicates [46]. Therefore, mixed-type self-setting formulations consisting of calcium orthophosphates and other calcium salts, such as calcium sulfate [54,55,56,57,58,59,60,61,62,63], calcium pyrophosphate [64,65,66], calcium polyphosphates [67,68], calcium carbonates [16,26,28,30,50,69,70,71], calcium oxide [72,73,74,75,76,77], calcium hydroxide [78,79,80], calcium aluminates [43,81,82], calcium silicates [83,84,85,86,87,88,89], etc ., are available. In addition, other chemicals such as Sr-containing compounds [19,90,91,92,93], Mg-containing compounds [93,94,95,96,97,98,99,100], Zn-containing compounds [101,102], etc ., might be added to calcium orthophosphates as well.…”

Section: Introductionmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

View full text Add to dashboard Cite

In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

show abstract

“…Due to the great potential of hydroxyapatite to host a variety of ions in its crystal lattice, ion substitution of HA has become the subject of intense investigations. The synergistic effect of Mg and CO 3 on reducing crystallinity and increasing the extent of dissolution has been confirmed in the previous studies [13]. Besides a biomimetic approach, introduction of antibacterial agents into the cement structure, especially silver is the subject of intensive research.…”

Section: Introductionmentioning

confidence: 61%

How calcite and modified hydroxyapatite influence physicochemical properties and cytocompatibility of alpha-TCP based bone cements

Zima

Czechowska

Siek

et al. 2017

J Mater Sci: Mater Med

Self Cite

View full text Add to dashboard Cite

Nowadays successful regeneration of damaged bone tissue is a major problem of the reconstructive medicine and tissue engineering. Recently a great deal of attention has been focused on calcium phosphate cements (CPCs) as the effective bone fillers. Despite a number of studies regarding CPCs, only a few compare the physicochemical and biological properties of α-TCP based materials of various phase compositions. In our study we compared the effect of several components (calcite, hydroxyapatite doped with Mg2+, CO3 2− or Ag+ ions, alginate, chitosan and methylcellulose) on the physicochemical and biological properties of α-TCP-based bone cements. The influence of materials composition on their setting times, microstructure and biochemical stability in simulated body fluid was determined. A number of in vitro laboratory methods, including ICP-OES, metabolic activity test, time-lapse microscopic observation and SEM observations were performed in order to assess biocompatibility of the studied biomaterials. The positive outcome of XTT tests for ceramic extracts demonstrated that all investigated cement-type composites may be considered cytocompatible according to ISO 10993-5 standard. Results of our research indicate that multiphase cements containing MgCHA, AgHA and calcite combined with αTCP enhanced cell viability in comparison to material based only on αTCP. Furthermore materials containing chitosan and methylcellulose possessed higher cytocompatibility than those with alginate.Graphical abstract

show abstract

Study on the new bone cement based on calcium sulfate and Mg, CO3 doped hydroxyapatite

Cited by 35 publications

References 36 publications

Surface Characterization and Biocompatibility of Selenium‐Doped Hydroxyapatite Coating on Titanium Alloy

Surface Characterization and Biocompatibility of Selenium‐Doped Hydroxyapatite Coating on Titanium Alloy

Self-Setting Calcium Orthophosphate Formulations

How calcite and modified hydroxyapatite influence physicochemical properties and cytocompatibility of alpha-TCP based bone cements

Contact Info

Product

Resources

About