Study on the differences of opinions and choices of high-risk breast cancer populations in China before and after genetic testing

Cheng, Xiaoqiang; Gu, Zhangyuan; Sun, Xin; Zhuang, Zhixiong

doi:10.21037/tcr.2019.11.43

Cited by 5 publications

(6 citation statements)

References 25 publications

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“…We found that 67% of community members knew about GT and that 45% held positive views toward GT, but only 4% have used GT. The general attitude toward GT among laypersons that we identified in our study was similar to the attitude reported in previous studies: That patients or high-risk populations hold a positive or neutral view of diseasespecific GT in China (Cheng et al, 2019;Zhang et al, 2019).…”

Section: Discussionsupporting

confidence: 87%

Public perceived knowledge of, attitude toward, and use of genetic testing in urban China

Wang

Pang

Meng

et al. 2021

Journal of Genetic Counseling

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Because most research about laypeople and genetic testing (GT) has been conducted in other nations than China, we conducted a study in urban China (a) to determine the perceived knowledge of, attitude toward, and use of GT there; (b) to identify influencing factors associated with the public's perceived knowledge, attitudes, and use of GT; and (c) to explore the relationship among public knowledge of, attitude toward, and use of GT. Our data came from a community-based survey in urban Dalian of 868 individuals. We used generalized ordered logit and logit models to examine factors associated with perceived knowledge of, attitude toward, and use of GT. We found that 67% of community members knew about GT, that 45% had a positive opinion of GT, and that only 4% accessed GT. Older people were more likely to have less perceived knowledge of GT and less likely to have a negative attitude toward it; these relationships were especially stronger among those aged ≥60 years. We also found that socially disadvantaged people were more likely to have less perceived knowledge of GT and more likely to have a negative opinion of it. Having a greater level of perceived knowledge was significantly correlated with increased odds of having a more positive or neutral attitude toward GT and of being more likely to access GT. Our findings may help policy makers design effective action plans and regulations regarding GT and genetic counseling services for laypersons in China.

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Section: Discussionsupporting

confidence: 87%

Public perceived knowledge of, attitude toward, and use of genetic testing in urban China

Wang

Pang

Meng

et al. 2021

Journal of Genetic Counseling

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“…A high endorsement was also found in a large sample of 1500 Korean individuals from general public, 1500 cancer patients, 113 clinicians, and 413 researchers, with the majority of participants being positive towards genetic testing (from 88.5% among clinicians to 94.3% among patients [19]. A somewhat lower endorsement (63.8%) was shown by a study of Chinese individuals at high risk of breast cancer [20].…”

Section: Willingness To Undergo Genetic Testingmentioning

confidence: 81%

Attitudes towards genetic testing: The role of genetic literacy, motivated cognition, and socio-demographic characteristics

Likhanov,

Zakharov,

Awofala

et al. 2023

PLoS ONE

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Understanding reasons for why people choose to have or not to have a genetic test is essential given the ever-increasing use of genetic technologies in everyday life. The present study explored the multiple drivers of people’s attitudes towards genetic testing. Using the International Genetic Literacy and Attitudes Survey (iGLAS), we collected data on: (1) willingness to undergo testing; (2) genetic literacy; (3) motivated cognition; and (4) demographic and cultural characteristics. The 37 variables were explored in the largest to-date sample of 4311 participants from diverse demographic and cultural backgrounds. The results showed that 82% of participants were willing to undergo genetic testing for improved treatment; and over 73%—for research. The 35 predictor variables together explained only a small proportion of variance: 7%—in the willingness to test for Treatment; and 6%—for Research. The strongest predictors of willingness to undergo genetic testing were genetic knowledge and deterministic beliefs. Concerns about data misuse and about finding out unwanted health-related information were weakly negatively associated with willingness to undergo genetic testing. We also found some differences in factors linked to attitudes towards genetic testing across the countries included in this study. Our study demonstrates that decision-making regarding genetic testing is influenced by a large number of potentially interacting factors. Further research into these factors may help consumers to make decisions regarding genetic testing that are right for their specific circumstances.

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“…The purpose is to accurately estimate the probability of cancer susceptibility gene mutations ( 89 ) and offer early prevention advice and medical management such as regular surveillance, chemoprevention or surgical prevention for BRCA mutation carriers ( 27 , 28 ). In a study with 839 breast cancer patients and 510 relatives, who are considered high-risk populations, 86.4% and 63.8% cases showed a strong willingness to accept genetic counseling and genetic testing, respectively ( 90 ). For those high-risk populations who are willing to do the genetic testing of BRCA1/2 , the mutation rate was 19.9%.…”

Section: Genetic Counseling For Brca Mutation Carr...mentioning

confidence: 99%

“…For those high-risk populations who are willing to do the genetic testing of BRCA1/2 , the mutation rate was 19.9%. Despite the high willingness, most of the high-risk individuals lacked knowledge of cancer inheritance ( 90 ). We are glad to find out that another study exhibited that 79% of germline mutation carriers were aware of the risk and the importance of surveillance, while 56% accepted preventive interferences after genetic counseling on gynecologic tumors ( 91 ).…”

Section: Genetic Counseling For Brca Mutation Carr...mentioning

confidence: 99%

Overview on population screening for carriers with germline BRCA mutation in China

Lei

Zhang²,

Zhang³

et al. 2022

Front. Oncol.

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Carriers with BRCA1/2 germline pathogenic variants are associated with a high risk of breast and ovarian cancers (also pancreatic and prostate cancers). While the spectrum on germline BRCA mutations among the Chinese population shows ethnic specificity, the identification of carriers with germline BRCA mutation before cancer onset is the most effective approach to protect them. This review focused on the current status of BRCA1/2 screening, the surveillance and prevention measures, and discussed the issues and potential impact of BRCA1/2 population screening in China. We conducted literature research on databases PubMed and Google Scholar, as well as Chinese databases CNKI and Wangfang Med Online database (up to 31 March 2022). Latest publications on germline BRCA1/2 prevalence, spectrum, genetic screening as well as carrier counseling, surveillance and prevention were captured where available. While overall 15,256 records were retrieved, 72 publications using germline BRCA1/2 testing were finally retained for further analyses. Germline BRCA1/2 mutations are common in Chinese patients with hereditary breast, ovarian, prostate and pancreatic cancers. Within previous studies, a unique BRCA mutation spectrum in China was revealed. Next-generation sequencing panel was considered as the most common method for BRCA1/2 screening. Regular surveillance and preventive surgeries were tailored to carriers with mutated-BRCA1/2. We recommend that all Chinese diagnosed with breast, ovarian, pancreatic or prostate cancers and also healthy family members, shall undergo BRCA1/2 gene test to provide risk assessment. Subsequently, timely preventive measures for mutation carriers are recommended after authentic genetic counseling.

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Study on the differences of opinions and choices of high-risk breast cancer populations in China before and after genetic testing

Cited by 5 publications

References 25 publications

Public perceived knowledge of, attitude toward, and use of genetic testing in urban China

Public perceived knowledge of, attitude toward, and use of genetic testing in urban China

Attitudes towards genetic testing: The role of genetic literacy, motivated cognition, and socio-demographic characteristics

Overview on population screening for carriers with germline BRCA mutation in China

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