Small distributed scientific monitoring equipment is an advanced concept in deep space exploration that requires a special power system. A micro‐radioisotope thermoelectric (TE) generator has the advantages of being of small volume, lightweight, and having a long life, which is regarded as the first choice. An annular radial TE conversion structure integrating 30 TE legs in 8.8 cm3 is designed, and a satisfactory temperature difference of 188.4 K is demonstrated. The p‐type Sb2Te3 and n‐type Bi2Te2.7Se0.3 TE thick films are prepared by screen printing, and Seebeck coefficients are 142.4 and −179.8 μV K−2, respectively. By serial–parallel stacking, modular single‐layer devices are effectively integrated on a large scale. The 900 TE legs are integrated into 15.86 cm3, which can provide a high voltage output of up to 13.2 V. When an electric heating source that simulates 3PuO2 is loaded, an open circuit voltage of 3.84 V and a maximum power of 1.26 mW can be obtained. As a demonstration, a prototype to drive a wireless sensor network is used. In the future, this kind of independent power source is expected to become a help for small autonomous and distributed scientific instruments.