Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth

Tang, Guangmin; Li, Xiaoli; Sun, Weijun; Liang, Yuan; Gan, Deqiang; Liu, Guangli; Song, Wen-Jie; Wang, Zhang

doi:10.1016/j.jep.2020.112831

Cited by 20 publications

(20 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…P. mira nut oil also increased the mRNA and protein expression of β-catenin. Skin irritation assay showed that application of P. mira nut oil on New Zealand rabbit skin caused mild erythema, which disappeared within 1 h of treatment [ 61 ]. Truong et al demonstrated that red ginseng oil and its constituents linoleic acid and β-sitosterol promoted hair re-growth in testosterone-treated mouse skin through early induction of anagen phase after once daily application for 28 days.…”

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

111

105

View full text Add to dashboard Cite

Persistent hair loss is a major cause of psychological distress and compromised quality of life in millions of people worldwide. Remarkable progress has been made in understanding the molecular basis of hair loss and identifying valid intracellular targets for designing effective therapies for hair loss treatment. Whereas a variety of growth factors and signaling pathways have been implicated in hair cycling process, the activation of Wnt/β-catenin signaling plays a central role in hair follicle regeneration. Several plant-derived chemicals have been reported to promote hair growth by activating Wnt/β-catenin signaling in various in vitro and in vivo studies. This mini-review sheds light on the role of Wnt/β-catenin in promoting hair growth and the current progress in designing hair loss therapies by targeting this signaling pathway.

show abstract

Section: Progress In Developing Therapy For Hair Loss By Targetingmentioning

confidence: 99%

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Choi

2020

IJMS

111

105

View full text Add to dashboard Cite

show abstract

“…Various plant extracts and chemicals with hair-growth-stimulating effects have been reported. Although precise underlying mechanisms remain unknown, these extracts and chemicals are considered to elicit these effects by accelerating blood flow, inducing a shift from telogen to anagen, mediating activation of the dermal papilla, inhibiting dihydrotestosterone, and exerting anti-inflammatory effects ( Junlatat and Sripanidkulchai, 2014 ; Kim et al, 2014 ; Park et al, 2017 ; Shen et al, 2018 ; Zhang et al, 2019 ; Zhou et al, 2020 ). The hair follicle contains several different types of cells; among these, the dermal papilla cells are major components of hair that play a critical role in inducing anagen phase and maintaining hair growth.…”

Section: Discussionmentioning

confidence: 99%

Fisetin Promotes Hair Growth by Augmenting TERT Expression

Kubo

Ogawa

Uehara

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Although thinning hair and alopecia are not recognized as severe diseases, hair loss has implications for mental health and quality of life; therefore, a large number of studies have been carried out to develop novel hair growth agents. In the present study, we aimed to examine the potential of telomerase reverse transcriptase (TERT), because TERT overexpression in skin activates resting hair follicle bulge stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis. To this end, we screened polyphenols that activate TERT expression in keratinocytes, and identified resveratrol and fisetin as strong hTERT-augmenting compounds. These polyphenols also regulated the gene expression of cytokines such as IGF-1 and KGF, which activate the β-catenin pathway, and TGF-β1, which plays an important role in maintaining the niche of hair follicle stem cells, thus are thought to play roles in promoting hair growth. We additionally showed that these polyphenols, especially fisetin, promoted hair growth from the shaved dorsal skin of mice, which suggests that these polyphenols activate the transition from telogen to anagen phase. Histological studies indicated that the dorsal skin of mice treated with these polyphenols contained numerous hair follicles and was thickened compared with that in control mice. Furthermore, on the dorsal skin of mice treated with resveratrol and fisetin, a number of proliferating cells (Ki67 + cells) were observed around the hair papilla. These results suggest that resveratrol and fisetin induce a shift from telogen to anagen in the hair follicle by inducing proliferation of hair follicle bulge stem cells, thus promoting hair growth.

show abstract

“…Prunus mira Koehne (PK) is a wild peach species that contains various nutrients and fatty acids [152]. Zhou et al, showed the hair-promoting effect of nut oil from PK [42]. They demonstrated that nut oil from PK increased hair length in mice and upregulated Wnt10B, β-catenin, and GSK-3β expression in mice [42].…”

Section: Wnt/β-cateninmentioning

confidence: 99%

“…Zhou et al, showed the hair-promoting effect of nut oil from PK [42]. They demonstrated that nut oil from PK increased hair length in mice and upregulated Wnt10B, β-catenin, and GSK-3β expression in mice [42]. Costunolide, a constituent of Saussurea lappa, has been used as an antioxidant, anti-inflammatory, and anticancer agent [153][154][155].…”

Section: Wnt/β-cateninmentioning

confidence: 99%

Modulation of Hair Growth Promoting Effect by Natural Products

Park

Lee

2021

Pharmaceutics

View full text Add to dashboard Cite

A large number of people suffer from alopecia or hair loss worldwide. Drug-based therapies using minoxidil and finasteride for the treatment of alopecia are available, but they have shown various side effects in patients. Thus, the use of new therapeutic approaches using bioactive products to reduce the risk of anti-hair-loss medications has been emphasized. Natural products have been used since ancient times and have been proven safe, with few side effects. Several studies have demonstrated the use of plants and their extracts to promote hair growth. Moreover, commercial products based on these natural ingredients have been developed for the treatment of alopecia. Several clinical, animal, and cell-based studies have been conducted to determine the anti-alopecia effects of plant-derived biochemicals. This review is a collective study of phytochemicals with anti-alopecia effects, focusing mainly on the mechanisms underlying their hair-growth-promoting effects.

show abstract

Study on the chemical constituents of nut oil from Prunus mira Koehne and the mechanism of promoting hair growth

Cited by 20 publications

References 15 publications

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

Fisetin Promotes Hair Growth by Augmenting TERT Expression

Modulation of Hair Growth Promoting Effect by Natural Products

Contact Info

Product

Resources

About