Modulation of Hair Growth Promoting Effect by Natural Products

Park, Sung Yong; Lee, Joomin

doi:10.3390/pharmaceutics13122163

Cited by 23 publications

(21 citation statements)

References 212 publications

(294 reference statements)

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“…Consequently, research into the development of therapeutic agents against alopecia is increasing. Currently, more and more attention has been focused on natural extracts from plants due to their lower toxicity [ 23 ]. However, natural compounds for treating alopecia in the clinic are still lacking.…”

Section: Discussionmentioning

confidence: 99%

Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway

et al. 2023

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Hordenine is effective in treating hyperpigmentation, fighting diabetes and resisting fibrosis and acute inflammation. However, the role of Hordenine on hair growth has not been elucidated. Here, we found that Hordenine treatments significantly enhance proliferation of primary mouse dermal-papilla cells (DPCs) and increase the activity of DPCs in a dose-dependent manner. Additionally, Hordenine markedly promoted the elongation of the hair shaft in the model of in vitro-cultured mouse vibrissa follicle and accelerated hair regrowth in a mouse model of depilation-induced hair regeneration. Real-time PCR, Western Blot and immunofluorescent assays showed that nuclear β-catenin and its downstream gene expression such as Lef1, Axin2, Cyclin D1 and ALP were greatly upregulated in DPCs and mouse hair follicles after Hordenine treatments. Moreover, the increased DPCs’ proliferation and hair shaft elongation of cultured mouse vibrissa follicles induced by Hordenine treatments were rescued by a Wnt/β-catenin signaling inhibitor, FH535. These data indicate that Hordenine can effectively enhance DPCs’ activity and accelerate hair regrowth through activating the Wnt/β-catenin signaling pathway. Therefore, these findings suggest Hordenine/its derivatives may be potentially used for preventing and treating alopecia in the future.

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Section: Discussionmentioning

confidence: 99%

Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway

et al. 2023

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“…Hair growth involves the growth and differentiation of hair follicles comprising dermal papilla cells and epithelial cells [ 1 ]. The life cycle of a hair follicle is divided into three phases: anagen (growth), catagen (regression), and telogen (rest) [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways

Hwang

Park

Lee

2022

IJMS

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Fish-derived collagen has recently emerged as an alternative collagen source with bioactive properties, including the enhancement of hair and skin health. It is also cost-effective and has high bioavailability, in addition to having fewer side-effects compared to collagen from porcine skin or bovine skin. Collagen peptides (CPs) extracted from the scales of Mozambique tilapia (Oreochromis mossambicus) reportedly promote hair and skin health. This study sought to evaluate the effects of CPs on hair growth using in vitro and in vivo models. CP significantly enhanced hair regrowth and the proliferation of human dermal papilla cells (hDPCs) in vitro. CP was orally administered to C57BL/6 mice for 6 weeks to confirm the hair-growth-promoting effects. The mice were divided into four groups: negative control (distilled water), positive control (1 mg/kg of finasteride), CP500 (500 mg/kg of CP), and CP1000 (1000 mg/kg of CP). CP treatment significantly enhanced the proliferation of hDPCs compared to 0.2 μM finasteride, in addition to enhancing hair regrowth. Particularly, CP1000 treatment achieved a hair-growth index similar to that of the PC. In H&E staining, the CP groups exhibited a high A/T ratio. Furthermore, CP increased the expression of hair growth factors (IGF-1, VEGF, krt27, Gprc5d, and Ki67) and decreased the growth inhibitory factor (TGF-β1). Furthermore, CP significantly upregulated the Wnt/β-catenin pathways and downregulated the BMP pathways. Therefore, these results indicate that CP could be used as food supplements and nutraceuticals for hair loss prevention as well as hair regrowth during alopecia.

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“…El uso de sustancias de origen vegetal con potencial anticaída genera cada vez más interés como estrategia complementaria en la prevención de la alopecia. Estos compuestos, entre los que destacan el extracto de Serenoa serrulata y el tocoferol, se incluyen en productos como tónicos, promotores del crecimiento capilar, acondicionadores y champús [11,12]. Tanto S. serrulata, con propiedades inhibidoras de la 5-alfa-reductasa [13,14], como los tocotrienoles, potentes antioxidantes pertenecientes a la familia de la vitamina E, han demostrado un efecto beneficioso frente a la alopecia [15][16][17].…”

Section: Introductionunclassified

Eficacia en alopecia de un acondicionador anticaída con Serenoa serrulata y tocoferol. Estudio piloto

Otal¹,

Ferrara²,

Grau³

et al. 2022

Medicina Estética

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RESUMENIntroducción. La alopecia androgenética (AGA) se caracteriza por una mayor actividad de la 5 alfa-reductasa, que acelera el ciclo capilar y acorta su duración. Además, se afectan el tejido conjuntivo y las unidades pilosebáceas circundantes. El objetivo principal de este estudio consistió en valorar la eficacia frente a la alopecia de la aplicación 3-4 veces/semana de un acondicionador capilar con extracto de Serenoa serrulata (inhibidor de la 5 alfa-reductasa) y tocoferol durante 90 días. Materiales y método. Estudio piloto abierto, no aleatorizado, simple ciego, llevado a cabo en 40 voluntarios con AGA. Se valoró el número de cabellos desprendidos mediante ensayos de peinado y lavado, la cantidad de sebo y la firmeza del cuero cabelludo. Se realizó una encuesta de satisfacción de los pacientes. Resultados. La alopecia se redujo significativamente en un 38% y un 34% a los 45 y 90 días, respectivamente. Se observó una reducción significativa del sebo del 40% y 43% a los 45 y 90 días. El desplazamiento de la sonda del indentómetro se redujo de forma significativa en un 21% y 19% a los 45 y 90 días, respectivamente. No se notificaron efectos secundarios. El 70% de los sujetos se mostraron satisfechos con el tratamiento. Conclusiones. La aplicación de un acondicionador capilar con S. serrulata y tocoferol, 3-4 veces/semana durante 90 días, ha demostrado ser eficaz, tanto en mujeres como en hombres, en términos de reducción de la alopecia, disminución del sebo capilar y mayor firmeza del cuero cabelludo. El producto fue bien tolerado y aceptado. Palabras clave. Alopecia androgenética. Cuero cabelludo. 5-alfa-reductasa. Sebo. Acondicionador. Serenoa serrulata. Tocoferol.

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Modulation of Hair Growth Promoting Effect by Natural Products

Cited by 23 publications

References 212 publications

Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway

Hordenine Activated Dermal Papilla Cells and Promoted Hair Regrowth by Activating Wnt Signaling Pathway

Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways

Eficacia en alopecia de un acondicionador anticaída con Serenoa serrulata y tocoferol. Estudio piloto

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