Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Zhou, Xue; Li, Ben; Wang, Chao; Li, Zhihong

doi:10.12669/pjms.36.6.1982

Cited by 4 publications

(5 citation statements)

References 19 publications

(22 reference statements)

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“…According to Tanguy f et al, the pathological mechanisms of SCH during pregnancy are associated with the resulting dyslipidemia and not only with the thyroid hormone levels. 14 Zhou X et al 15 showed that vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. 15 The results of this study are consistent with this, but vitamin D is not observed this time, which is one of the limitations of this paper.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism

Zhang¹,

Chen²,

Dou³

et al. 2023

Pak J Med Sci

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Objective: To investigate the association between gestational blood lipids and thyroid stimulating hormone (TSH) levels and pregnancy outcomes of patients with subclinical hypothyroidism (SCH). Methods: In this retrospective observational study, we analyzed the clinical data of 82 patients (case group) with gestational SCH treated in our hospital from January 2021 to January 2022 at gestational weeks 25-33 and grouped them according to whether SCH was well controlled by treatment (case Group-A: well controlled, n=55; case Group-B: poorly controlled, n=27), and the clinical data of 41 pregnant women (control group) undergoing physical examination during the same period. After comparing the blood lipids and TSH levels of the three groups, we compared their adverse pregnancy outcomes to assess the possible correlations between blood lipids and TSH levels and pregnancy outcomes. Results: The levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and TSH in the case Group-B were significantly higher than those in the case Group-A and the control group (P<0.05). Compared with case Group-B and the control group, the incidence of premature delivery, abortion and neonatal growth restriction was higher in case Group-A (P<0.05). Among 82 patients in the case group 42 presented adverse pregnancy outcomes. The levels of TC, TG, LDL-C and TSH in mothers and infants in the adverse outcome group were significantly higher than those in the favorable outcome group (P<0.05). Our Pearson analysis results showed that the levels of TC, TG and LDL-C were positively correlated with the TSH levels and the pregnancy outcomes, and that TSH was positively correlated with pregnancy outcomes (P<0.05). Conclusion: The levels of TC, TG, LDL-C and TSH in patients with poorly controlled SCH were increased during pregnancy, and were associated with the pregnancy outcomes and positively correlated with each other. doi: https://doi.org/10.12669/pjms.39.3.7150 How to cite this: Zhang J, Chen H, Dou X, Huang W, Zeng H. Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism. Pak J Med Sci. 2023;39(3):721-725. doi: https://doi.org/10.12669/pjms.39.3.7150 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

“…14 Zhou X et al 15 showed that vitamin D deficiency in the first trimester is associated with in an increased level of TSH in the first trimester, thereby aggravating subclinical hypothyroidism. 15 The results of this study are consistent with this, but vitamin D is not observed this time, which is one of the limitations of this paper.…”

Section: Discussionmentioning

confidence: 99%

Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism

Zhang¹,

Chen²,

Dou³

et al. 2023

Pak J Med Sci

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“…In multivariate Logistic analysis, elevated TSH levels were significantly correlated with gender, FT3/FT4, TPO-Ab, Tg-Ab, CR, TC, and TG. TC ( 7 ), gender ( 8 ), TPO-Ab ( 9 ), Tg-Ab ( 10 ), CR, and TG all have involvement in thyroid diseases. For example, males have a higher risk of recurrence in patients with papillary thyroid carcinoma than females ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Predicting Elevated TSH Levels in the Physical Examination Population With a Machine Learning Model

Cheng

Deng

et al. 2022

Front. Endocrinol.

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ObjectiveThe purpose of this study was to predict elevated TSH levels by developing an effective machine learning model based on large-scale physical examination results.MethodsSubjects who underwent general physical examinations from January 2015 to December 2019 were enrolled in this study. A total of 21 clinical parameters were analyzed, including six demographic parameters (sex, age, etc.) and 15 laboratory parameters (thyroid peroxidase antibody (TPO-Ab), thyroglobulin antibody (TG-Ab), etc.). The risk factors for elevated TSH levels in the univariate and multivariate Logistic analyses were used to construct machine learning models. Four machine learning models were trained to predict the outcome of elevated TSH levels one year/two years after patient enrollment, including decision tree (DT), linear regression (LR), eXtreme Gradient boosting (XGBoost), and support vector machine (SVM). Feature importance was calculated in the machine learning models to show which parameter plays a vital role in predicting elevated TSH levels.ResultsA total of 12,735 individuals were enrolled in this study. Univariate and multivariate Logistic regression analyses showed that elevated TSH levels were significantly correlated with gender, FT3/FT4, total cholesterol (TC), TPO-Ab, Tg-Ab, creatinine (Cr), and triglycerides (TG). Among the four machine learning models, XGBoost performed best in the one-year task of predicting elevated TSH levels (AUC (0.87(+/- 0.03))). The most critical feature in this model was FT3/FT4, followed by TPO-Ab and other clinical parameters. In the two-year task of predicting TSH levels, none of the four models performed well.ConclusionsIn this study, we trained an effective XGBoost model for predicting elevated TSH levels one year after patient enrollment. The measurement of FT3 and FT4 could provide an early warning of elevated TSH levels to prevent relative thyroid diseases.

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“…Vitamin D is regarded as one of the natural immune modulators and a regulator of several immune-mediated processes, in addition to its roles in calcium/phosphate homeostasis [ 30 ]. Some studies have found that vitamin D deficiency is related to thyroid disorder in pregnant women [ 5 , 31 ]. Nevertheless, there have also been some reports contradicting such a relationship [ 12 , 32 ], making it challenging to come to a consensus regarding the relationship between pregnant women’s thyroid function and vitamin D status.…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid-related pathophysiologic changes may be aggravated by pregnancy, and some obstetric conditions, such as gestational trophoblastic disease or hyperemesis gravidarum, may also affect thyroid gland function [ 3 , 4 ]. Recent research has revealed a connection between thyroid malfunction and vitamin D deficiency in pregnant women [ 5 , 6 ]. This finding is interesting, because both vitamin D deficiency and thyroid dysfunction are a matter of concern to women during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The Interactive Effects of Severe Vitamin D Deficiency and Iodine Nutrition Status on the Risk of Thyroid Disorder in Pregnant Women

Wang

Sun

et al. 2022

Nutrients

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Thyroid dysfunction is associated with both vitamin D deficiency and iodine; however, it is unclear whether they interact. This study aimed to investigate whether and to what extent the interactions between vitamin D and iodine contribute to the risk of thyroid disorder. Participants (n = 4280) were chosen using multistage, stratified random sampling from Shanghai. Fasting blood was drawn for the 25(OH)D and thyroid parameter tests. Spot urine samples were gathered to test for urine iodine. To evaluate the interactive effects of vitamin D and iodine, crossover analysis was carried out. Pregnant women with a high urinary iodine concentration (UIC) and severe vitamin D deficiency had a significantly higher risk of thyrotropin receptor antibody (TrAb) positivity (odds ratio = 2.62, 95% confidence interval (CI): 1.32, 5.22) in the first trimester. Severe vitamin D deficiency and high UIC interacted positively for the risk of TrAb positivity (relative excess risk due to interaction = 1.910, 95%CI: 0.054, 3.766; attributable proportion = 0.700, 95%CI: 0.367, 1.03). Severe vitamin D deficiency combined with excess iodine could increase the risk of TrAb positivity in pregnant women in the first trimester.

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Study on the changes in TSH, TPO-Ab and other indicators due to Vitamin D deficiency in Pregnant Women with subclinical hypothyroidism in the first trimester

Cited by 4 publications

References 19 publications

Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism

Association between gestational blood lipids and TSH levels and pregnancy outcome of patients with subclinical hypothyroidism

Predicting Elevated TSH Levels in the Physical Examination Population With a Machine Learning Model

The Interactive Effects of Severe Vitamin D Deficiency and Iodine Nutrition Status on the Risk of Thyroid Disorder in Pregnant Women

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