Study on Texture Features of Cingulum in Different Gender Patients with Alzheimer’s Disease and Mild Cognitive Impairment Based on MR Images

Abstract

The aim of this article is to study the texture features of cingulum in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) based on magnetic resonance images, and explore the texture differences derived from different gender among each group. Texture analysis was performed on 7 AD patients, 14 MCI patients and 11 normal controls (NC). Texture features extracted from gray level co-occurrence matrix and run-length matrix were analyzed between each two groups. The results showed that texture features of the anterior cingulum had significant differences in the multiple comparisons and features of the posterior cingulum had significant differences between AD and MCI group as well as AD and NC group. There were significant differences between AD and MCI group as well as AD and NC group in male’s cingulum. While in female’s cingulaum, the differences were founded between AD and NC group. The results indicated that the pathological changes in cingulum could be reflected by texture features and the pathological changes may be different in the two genders.

Longitudinal change of the grey matter of mild congnitive impairment patients over 3 years by using voxel-based morphometry

“…Texture features of the hippocampus were extracted from gray level co-occurrence matrix and run length matrix, and were tested significant differences among AD, MCI and NC [17]. Pathological changes in cingulum in AD group could also be reflected by texture features [18]. Besides, we also find the hippocampal changes with increasing age were essentially different from the pathological changes with AD [19].…”

“…All participants underwent a clinical screening procedure including Mini-Mental State Examination (MMSE) and Clinical Dementia Rating (CDR) scores at the first scanning Table I. At the baseline of the MCI, the average age was 74.5(range, 62.8-89.1) and the average MMSE was 26.3(range, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30]. The MMSE reflects a global measure of mental status based on evaluation of five cognitive domains.…”