Longitudinal change of the grey matter of mild congnitive impairment patients over 3 years by using voxel-based morphometry

Abstract

The atrophic changes in mild cognitive impairment (MCI) have been proposed as biomarkers for detection and monitoring. This paper analyzed magnetic resonance imaging (MRI) to identify the atrophy regions of the whole brain grey matter (GM) in longitudinal MCI group. Based on the method of voxel-based morphometry (VBM), the two-sample t test was performed to compare MCI (n=21) in the initial stage (baseline) and that in 3 years which were got from ADNI. Our results are as followed, 3 years later, the regions of GM atrophy(p<0.005, k≥200) included the bilateral temporal lobe, the bilateral cerebellum posterior lobe, the right frontal lobe, the left paracentral lobule, the right frontal lobe, the right anterior cingulate and the left declive. In addition, comparing the Alzheimer's disease (AD, n=23) group with normal control (NC, n=16) group, the atrophy regions were found to be consistent with the results of the longitudinal MCI data. The accelerated atrophy may result from neurofibrillary tangles and other pathological processes. The VBM analysis results which were assessed in longitudinal MCI may have a prognosis to the diagnosis of AD.

Extraction of dynamic functional connectivity from brain grey matter and white matter for MCI classification

“…In particular, this work emphasizes the roles of dFC as well as dFCT as the potential biomarkers for accurate diagnosis of MCI subjects. Note that several of these potential biomarkers detected by our study are shared by the biomarkers suggested by previous longitudinal studies [Yang et al, ], such as the frontal lobe and paracentral lobule. More importantly, the dFC and dFCT biomarkers suggested by our study can be used as the potential biomarker candidates in the future hypothesis‐orientated longitudinal studies for more comprehensive characterization of the trajectory of the neurodegeneration.…”

Alzheimer's detection at early stage using local measures on MRI: A comparative study on local measures

“…Another work on Computer-aided diagnostic reporting of FluDeoxyGlucose -Positron Emission Tomography (FDG-PET) for the diagnosis of AD is based on bio-markers which involve the statistical voxel-by-voxel comparison of FDG uptake compared to normative dataset. The Longitudinal Evaluation of Structural Changes in Frontotemporal Dementia [16] suggests that the neuron destruction reflects volume changes on brain tissues such as GM, WM and CSF. White matter loss is associated with neuro degenerative disorders.…”

Comparison of two VBM arithmetic based on Alzheimer's Disease MRI analysis

“…According to the report from the xjVIEW and used the predefined anatomical masks obtained from the automated anatomical labeling (AAL) [11], GM atrophy regions, the location and MNI coordinates were listed in Table 3.…”