Study on TEMPO-Mediated Oxidation of N-Succinyl Chitosan and the Water Retention Property

Li, Aoqi; Xue, Qinglan; Ye, Yingqing; Gong, Peixin; Deng, Mingyu

doi:10.3390/molecules25204698

Cited by 14 publications

(7 citation statements)

References 25 publications

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“…The CS diffractogram (Figure S1) showed an amorphous structure by showing several small diffraction peaks in the range of 2θ = 10°–20° and 2θ = 20°–30°, which comes in agreement with previous studies, , whereas the crystal structure of ACF particles in Figure S2 showed diffraction peaks at 2θ = 16.5°, 21.8°, 23.9°, 25.2°, 25.6°, and 31°, which came in agreement with the reported data . The presence of ACF in PMs was confirmed using the XRD patterns (Figure ).…”

Section: Resultssupporting

confidence: 91%

“…This means that ACF was completely trapped in the OSCS PMs at the molecular level, which might improve medication absorption. 41,42 2.4. Thermal Analysis.…”

Section: Resultsmentioning

confidence: 99%

“…There was also a minor ACF peak in ACF-loaded PMs, which had a spectrum similar to that of the blank micelles, although the ACF peak was unnoticeable. This means that ACF was completely trapped in the OSCS PMs at the molecular level, which might improve medication absorption. , …”

Section: Resultsmentioning

confidence: 99%

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Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles

Alenazi,

Bokhari,

Abourehab

et al. 2023

ACS Omega

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Amphiphilic micelles based on chitosan (CS) were applied as drug carriers of aceclofenac (ACF) as a potential method to induce its bioavailability and therapeutic efficiency. N -octyl- N , O -succinyl CS (OSCS), an amphiphilic CS derivative, was successfully synthesized and loaded physically by ACF at different pH values and using different dosages of ACF, forming ACF-loaded polymeric micelles (PMs). The obtained PMs and ACF-loaded PMs were characterized by different analytical techniques, including AFM, TEM, DLS, UV–vis spectrophotometry, 1 H NMR spectroscopy, and FT-IR spectroscopy. The pH 5 sample with a 30% ACF/polymer ratio showed the highest ACF loading capacity (LC) and entrapment efficiency (EE). In vitro release behaviors of pure ACF and ACF-loaded PMs at each release point indicated that the release profile of pH-responsive PMs loaded with ACF demonstrated quicker release rates (94% after 480 min) compared to the release behavior noticed for free ACF (59.56% after 480 min). Furthermore, the release rates exhibit a notable rise when the pH is increased from 1.2 to 4.7. In the carrageenan-induced inflammation model of paw edema in rats, it has been demonstrated that the injection of ACF-loaded PMs (at a dose of 10 mg/kg) resulted in a strengthened inflammatory activity compared to the injection of free ACF at equivalent dosages as well as at time intervals. However, the use of ACF-loaded PMs for a duration of 6 h displayed a notable reduction of paw edema, with an inhibition percentage of 85.09%, in contrast to the 74.9% inhibition percentage observed for the free ACF medication.

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Section: Resultssupporting

confidence: 91%

“…This means that ACF was completely trapped in the OSCS PMs at the molecular level, which might improve medication absorption. 41,42 2.4. Thermal Analysis.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles

Alenazi,

Bokhari,

Abourehab

et al. 2023

ACS Omega

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“…Chitosan with positive and negative chemical groups (zwitterionic) has previously been obtained using carboxymethylation and (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO)-mediated oxidation, with both utilizing halogen-based, hazardous stoichiometric chemicals. The succinylation of chitosan with succinic anhydride is a sustainable alternative for carboxymethylation and TEMPO-mediated oxidation, but it involves the use of organic solvents (e.g., dimethyl sulfoxide and dimethylformamide , ). Therefore, itaconic acid modification can be seen as a sustainable method for the introduction of carboxylic acid moiety in chitosan.…”

Section: Results and Discussionmentioning

confidence: 99%

Aqueous Modification of Chitosan with Itaconic Acid to Produce Strong Oxygen Barrier Film

et al. 2021

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In this study, the chemical modification of chitosan using itaconic acid as a natural-based unsaturated dicarboxylic acid was investigated. In an aqueous environment, the amine group of chitosan reacts with itaconic acid to produce a chitosan derivative with pyrrolidone-4-carboxylic acid group. On the basis of the elemental analysis, 15% of the amine groups of chitosan reacted, thus creating modified chitosan with amine and carboxylic acid functionalities. Due to the presence of amine and carboxylic acid groups, the surface charge properties of the chitosan were notably altered after itaconic acid modification. In an aqueous solution, the modified chitosan exhibited zwitterionic properties, being cationic at low pH and turning anionic when the pH was increased over 6.5, whereas the original chitosan remained cationic until pH 9. Furthermore, it was demostrated that the modified chitosan was suitable for the preparation of a self-standing film with similarly high transparency but notably higher mechanical strength and oxygen barrier properties compared to a film made from the original chitosan. In addition, the thermal stability of the modified chitosan film was higher than that of the original chitosan film, and the modified chitosan exhibited flame-retardant properties.

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“…Tzaneva et al have obtained CMCh with 50% DS and introduced the polymer to emulsions. They concluded that this chitosan derivate improves rheological properties of the emulsion and can replace one of the most frequently used stabilizers, Carbomer [ 118 ]. CMCh also has antibacterial properties; it shows even stronger effects than chitosan [ 117 ].…”

Section: Modification Of Chitosan For Cosmetic Applicationsmentioning

confidence: 99%

Chitosan Based Materials in Cosmetic Applications: A Review

Kulka

Sionkowska

2023

Molecules

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This review provides a report on the properties and recent advances in the application of chitosan and chitosan-based materials in cosmetics. Chitosan is a polysaccharide that can be obtained from chitin via the deacetylation process. Chitin most commonly is extracted from cell walls in fungi and the exoskeletons of arthropods, such as crustaceans and insects. Chitosan has attracted significant academic interest, as well as the attention of the cosmetic industry, due to its interesting properties, which include being a natural humectant and moisturizer for the skin and a rheology modifier. This review paper covers the structure of chitosan, the sources of chitosan used in the cosmetic industry, and the role played by this polysaccharide in cosmetics. Future aspects regarding applications of chitosan-based materials in cosmetics are also mentioned.

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Study on TEMPO-Mediated Oxidation of N-Succinyl Chitosan and the Water Retention Property

Cited by 14 publications

References 25 publications

Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles

Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles

Aqueous Modification of Chitosan with Itaconic Acid to Produce Strong Oxygen Barrier Film

Chitosan Based Materials in Cosmetic Applications: A Review

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