Drug Polymeric Carrier of Aceclofenac Based on Amphiphilic Chitosan Micelles
Noof A. Alenazi,
Mohammed G. Bokhari,
Mohammed A.S. Abourehab
et al.
Abstract:Amphiphilic micelles based on chitosan (CS) were applied
as drug
carriers of aceclofenac (ACF) as a potential method to induce its
bioavailability and therapeutic efficiency.
N
-octyl-
N
,
O
-succinyl CS (OSCS), an amphiphilic
CS derivative, was successfully synthesized and loaded physically
by ACF at different pH values and using different dosages of ACF,
forming ACF-loaded polymeric micelles (PMs). The obtained PMs and
ACF-loaded PMs were c… Show more
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