Study on Polyvinyl Alcohol Hydrogel Materials for Improving the Performance of Artificial Articular Cartilage

Abstract

Polyvinyl alcohol hydrogel has compatibility and biomechanical properties of human articular cartilage similar and good biological. The implantation in the human body can replace part of articular cartilage, which plays the role of bearing and alleviate the impact force. It has the prospect of clinical application. This paper introduces the research progress of polyvinyl alcohol hydro-gel materials. And compared with the characteristics of articular cartilage, clarify the possibility of repair of articular cartilage defects of the materials.

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“…Examples include its inclusion in ophthalmic solutions and tear replacement solutions without causing any discomfort to the eyes [ 98 ]. In recent years, PVOH hydrogels have found extensive use in cartilage replacement, tissue sealants for emphysema treatment, wound dressings with healing agents, and as a barrier against secondary infections [ 99 , 100 , 101 ]. The toxicity profile of PVOH was extensively evaluated after oral and intravenous injections of PVOH in animal models [ 102 , 103 ].…”

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“…Herein, we demonstrated a novel strategy based on triply reversible interactions to achieve this goal. Poly(vinyl alcohol) (PVA) was selected for its excellent biocompatibility, low cost, and ability to form coordination bonds with cations 49–53 . Aluminum sulfate was adopted as a conductive additive for three reasons.…”

“…Poly(vinyl alcohol) (PVA) was selected for its excellent biocompatibility, low cost, and ability to form coordination bonds with cations. [49][50][51][52][53] Aluminum sulfate was adopted as a conductive additive for three reasons. The immobile Al 3+ cations could coordinate with PVA chains to form a highly charged network, which was proven to be very sensitive to tiny deformations of the framework.…”