Polyvinyl alcohol based-drug delivery systems for cancer treatment

Rivera-Hernández, Gabriela; Antunes‐Ricardo, Marilena; Martínez-Morales, Patricia L.; Sánchez, María Amparo

doi:10.1016/j.ijpharm.2021.120478

Cited by 128 publications

(92 citation statements)

References 97 publications

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“…PVA is one of the most used synthetic polymers as a stabilizer agent due to its good biocompatibility, no carcinogenicity, hydrophilicity, non-toxicity, and biodegradability in human tissues and fluids [ 29 ]. Thus, in the biomedical field, it is widely used to prevent nucleation and slow crystal growth [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.

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Section: Resultsmentioning

confidence: 99%

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

et al. 2021

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“…Polyvinyl alcohol (PVA) is a type of synthetic polymer that is soluble in water, slightly soluble in ethanol, and insoluble in other organic solvents, making it a potential candidate as a raw material for hydrogel [26]. PVA has several superior characteristics, such as tasteless, odorless, adjustable mechanical properties, good for synthesizing membranes, compatible, and biodegradable in the human body [27].…”

Section: Introductionmentioning

confidence: 99%

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Asy-Syifa

Kusjuriansah

Waresindo

et al. 2022

J. Phys.: Conf. Ser.

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Hydrogel is composed of a three-dimensional network of hydrophilic polymers and can swell when placed in an aqueous media. Polyvinyl alcohol (PVA) is a common polymer used to produce hydrogels because it has biocompatibility, non-toxicity, chemical stability, low cost, and excellent mechanical strength. In this study, the PVA solutions were prepared with concentrations of 6%, 8%, 10%, and 12% in distilled water. The precursor solutions underwent a freeze-thaw cycle with a freezing temperature of -25 °C for 20 hours and a thawing temperature of 37 °C for 4 hours and carried out for 6 cycles. The swelling degree and the gel fraction of the hydrogel were then determined. From the swelling degree results, the increase of the PVA concentration in the precursor solutions reduced the swelling degree of the hydrogel. Based on the gel fraction test, it was revealed that all PVA concentrations have approximately the same value of gel fraction at 97%. Additionally, the viscosity and the density were also measured. Both showed an increasing trend with the addition of PVA concentration, where the viscosity values from the smallest to highest concentrations were 12.4944, 34.1737, 93.8491, and 216.2979 cP while the density values were 0.9865, 0.9871, 0.9878, and 0.9885 gram.cm-3.

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“…The nanoparticles were recovered by centrifugation (20,000 rpm for 20 min) Centrifugal Beckman Coulte TM J 25, Brea, California, USA) and washed twice with distilled water to remove the excess of PVA. Is important to point out that both polylactic acid (PLA) and Polyvinyl alcohol (PVA) are Food and Drug Administration approved polymers that have proven to be very versatile materials, with interesting properties such as biocompatibility and biodegradability [ 46 , 47 ].…”

Section: Methodsmentioning

confidence: 99%

Polymeric nanoparticles and nanomicelles of hydroxychloroquine co-loaded with azithromycin potentiate anti-SARS-CoV-2 effect

et al. 2022

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The outbreak of coronavirus (COVID-19) has put the world in an unprecedented scenario. To reestablish the world routine as promote the effective treatment of this disease, the world is looking for new (and old) drug that can efficiently kill the virus. In this study, we have developed two nanosystems: polymeric nanoparticles and nanomicelles-based on hydroxychloroquine and azithromycin. The nanosystem was fully characterized by AFM and DLS techniques. Also, the nanosystems were radiolabeled with 99m Tc and pulmonary applied (installation) in vivo to evaluate the biological behavior. The toxicity of both nanosystem were evaluated in primary cells (FGH). Finally, both nanosystems were evaluated in vitro against the SARS-CoV-2. The results demonstrated that the methodology used to produce the nanomicelles and the nanoparticle was efficient, the characterization showed a nanoparticle with a spherical shape and a medium size of 390 nm and a nanomicelle also with a spherical shape and a medium size of 602 nm. The nanomicelles were more efficient (~ 70%) against SARS-CoV-2 than the nanoparticles. The radiolabeling process with 99m Tc was efficient (> 95%) in both nanosystems and the pulmonary application demonstrated to be a viable route for both nanosystems with a local retention time of approximately, 24 h. None of the nanosystems showed cytotoxic effect on FGH cells, even in high doses, corroborating the safety of both nanosystems. Thus, claiming the benefits of the nanotechnology, especially with regard the reduced adverse we believe that the use of nanosystems for COVID-19 treatment can be an optimized choice. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40097-022-00476-3.

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Polyvinyl alcohol based-drug delivery systems for cancer treatment

Cited by 128 publications

References 97 publications

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

Collagen Hydrogels Loaded with Silver Nanoparticles and Cannabis Sativa Oil

The Study of the Swelling Degree of the PVA Hydrogel with varying concentrations of PVA

Polymeric nanoparticles and nanomicelles of hydroxychloroquine co-loaded with azithromycin potentiate anti-SARS-CoV-2 effect

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