Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C)

Chaudhary, Ankur; Aneja, G. K.; Shukla, Shubhra; Razi, Syed Mohd

doi:10.7860/jcdr/2015/13348.6376

Cited by 36 publications

(39 citation statements)

References 11 publications

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“…However, in our opinion, high LVDD prevalence in newly-diagnosed diabetics seems due to a delay in diagnosis. Beyond diabetes, there are others determinants of LVDD: we found a strong correlation between LVDD and hypercholesterolemia in a population of postmenopausal women affected by a mild-moderate hypertension [31]. This finding can be easily explained by an increased aortic stiffness and high peripheral resistance that compromise LV diastolic function in postmenopausal women.…”

Section: Discussionmentioning

confidence: 62%

Left ventricular diastolic dysfunction in normotensive postmenopausal women with type 2 diabetes mellitus

et al. 2017

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Section: Discussionmentioning

confidence: 62%

Left ventricular diastolic dysfunction in normotensive postmenopausal women with type 2 diabetes mellitus

et al. 2017

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“…Abay Kumar Chaudhary et al [9] in their study of 100 asymptomatic subjects found the prevalence of diastolic dysfunction in asymptomatic newly diagnosed Type 2 diabetics as 41%. [12] Mean of HbA1C (%) was found higher in group with LVDD (7.67±0.90) as compared to group without LVDD (7.24±0.64).…”

Section: Discussionmentioning

confidence: 99%

“…[9] Autonomic Neuropathy In cardiac autonomic neuropathy, the loss of parasympathetic activity results in relative predominance over sympathetic activity in the sympathovagal balance. The sympathetic overactivity stimulates renin angiotensin-aldosterone-adrenergic system which increases the heart rate, stroke volume and peripheral resistance.…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

A Study to Correlate Hba1c Levels and Left Ventricular Diastolic Dysfunction in Newly Diagnosed Type Ii Diabetes Mellitus

Perumal¹,

Narayanan²,

Rangarajan³

et al. 2016

jemds

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AIMTo assess the correlation of HBA1C levels with left ventricular diastolic dysfunction in newly diagnosed Type 2 diabetic patient. This prospective study was done at Department of General Medicine, OPD, Medical Wards, Stanley Medical College and Hospital, Chennai. RESULTThe mean HBA1C levels were meaningfully more in Left Ventricular Diastolic Dysfunction (LVDD) positive group compared to the LVDD negative group by 1.33%. This significant difference of 15% increase in mean HBA1C levels in LVDD positive group compared to the LVDD negative group is true and has not occurred by chance. CONCLUSIONOne-fifth to one-third of diabetic patients will develop LVDD. Patients with HBA1C (8 to 10) have double the chances to develop LVDD than with HbA1c 6.5 to 8. Patients with HBA1C more than 10 have five times the chances to develop LVDD than with HbA1C 6.5 to 8. Patients with HBA1C more than 10 have three times the chances to develop LVDD than with HBA1C 8 to 10. One-fourth to one-half of diabetic patients will develop LVDD grade 1. Patients with HBA1C 8 to 10 have double the chances to develop LVDD grade 1 than with HBA1C 6.5 to 8. Patients with HBA1C more than 10 have four times the chances to develop LVDD grade 1 than with HBA1C 6.5 to 8. Patients with HBA1C more than 10 have two times the chances to develop LVDD than with HBA1C 8 to 10. KEYWORDSType 2 Diabetes, Left Ventricular Diastolic Dysfunction, HbA1C. HOW TO CITE THIS ARTICLE:Perumal V, Narayanan N, Rangarajan J, et al. A study to correlate HbA1C levels and left ventricular diastolic dysfunction in newly diagnosed type II diabetes mellitus.

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“…The alteration in the functioning of Renin Angiotensin and Aldosterone Mechanism stimulates formation of myofibroblast leading to myocardial fibrosis. [8] Clinically, the patient develops no symptoms in early phase. Later, myocardial diastolic dysfunction occurs followed by systolic dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Diabetes Mellitus Type II: Correlation between HBA1C Level and Left Ventricular Diastolic Dysfunction

Dhar¹,

Lal²,

Thakuria³

et al. 2016

AIMDR

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Background: Diabetes is a metabolic disease which affects various organs of the body like heart, eye, kidney, skin and peripheral nerves. Diabetic cardiomyopathy is defined as the appearance of the symptoms of Congestive heart failure in diabetic patient in the absence of hypertension and any structural or congenital heart disease. The aim of the study is to find the relation between type 2 diabetes mellitus and cardiomyopathy, highlighting the variation in incidence according to age, sex and severity on basis of Doppler echocardiographic diagnosis. Methods: The prospective study was conducted for the duration of one year on 100 newly diagnosed Type 2 Diabetes patients aged between 30-60 years. Doppler echocardiography and HbA1c level of the patients was done. The study was conducted on the basis of grading of diastolic dysfunction on echocardiography. Quantitative data was analysed with the help of 't' test and qualitative data with the ChiSquare and Fisher Exact Test. Statistical significance was taken as P < 0.05. Results: In this study, 39% of the newly diagnosed type 2 diabetes mellitus patients developed diabetic cardiomyopathy. In females, the disease was statistically absent in more patients (35) as compared to males (26) (<0.05). The commonest age group affected by grade 1 disease was 41-50 years. The incidence of grade 2 disease was more in age group 51-60 years. The grade 1 diabetic cardiomyopathy was statistically more common in males as compared to females (<0.05). The grade 2 diabetic cardiomyopathy was more common in females, but was statistically insignificant. Patients with HbA1c <8 have 16% chances to get LVDD with significant P value of 0.02. Patients with HbA1c between 8 to 10 have 30% chances to get LVDD with significant P value of 0.01. Conclusion: Diabetic cardiomyopathy is an important complication of type 2 diabetes mellitus patient. HbA1c level and Doppler echocardiography plays an important role in estimating the prevalence and severity of diabetic cardiomyopathy.

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Study on Diastolic Dysfunction in Newly Diagnosed Type 2 Diabetes Mellitus and its Correlation with Glycosylated Haemoglobin (HbA1C)

Cited by 36 publications

References 11 publications

Left ventricular diastolic dysfunction in normotensive postmenopausal women with type 2 diabetes mellitus

Left ventricular diastolic dysfunction in normotensive postmenopausal women with type 2 diabetes mellitus

A Study to Correlate Hba1c Levels and Left Ventricular Diastolic Dysfunction in Newly Diagnosed Type Ii Diabetes Mellitus

Diabetes Mellitus Type II: Correlation between HBA1C Level and Left Ventricular Diastolic Dysfunction

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