Study on Clinical Presentation of Breast Carcinoma of 50 Cases

Abstract

Background: Breast cancer results from uncontrolled proliferation of malignant cells resulting appearance of a lump or a mass in the breast. Although many epidemiological risk factors have been identified, the cause of any individual breast cancer is most often unknowable. A women's reaction to any suspected disease of breast may include fear of disfigurement, loss of sexual attractiveness and death. Social and religious factors, unawareness of fatality of the disease, fear of infertility hinder early diagnosis & treatment. Early diagnosis is the key to increased survival. Objective: To find out clinical presentation for breast cancer. Study design: It is a prospective study of 50 carcinoma breast patients who palpable breast lump. It was conducted during the six months period. Data were collected pre-designed data collection sheet. Data were analysis statistical package for social science (SPSS) program. Result : Most of the malignant lesions are above the age of 40 years and peak incidence are between 41-50 years and most of patients under this study were in advanced stage-III (54%) and stage-IV (22%). Patients were presented as nipple discharge (20%), pain in the breast (26%), ulceration over the lump (14%), paeu'd orange (10%) skin fixation over the lump (18%), fixation to the chest wall (14%) nipple retraction (22%). Among the 50 patients there was only one male ca-breast patient (2%). Among the histopathological types infiltrating duct cell carcinoma (NST) were 41 (82%), ductal carcinoma in situ 6 (12%), lobular carcinoma invasive 2 (4%), lobular carcinoma in situ 1 (2%) and carcinoma involved in different quadrants were upper & outer 21 (42%), lower outer 5 (10%), upper and inner 12 (24%), lower and inner 4 (8%), central 7 (14%) and breast as a whole involvement was 1 (2%). About the involvement of carcinoma breast, left breast involvement were 52%, right breast 46% and bilateral involvement was 2%. Conclusion: This prospective study shows an alarming high incidence of carcinoma breast with palpable breast lump. The diversity of clinical presentation of breast lumps in different age group were observed is our hospital practice. This study gives an idea about the incidence of various types of lesions of breast in different age groups in our country.

Immunohistochemical profile of carcinoma breast and its association with clinicopathological features: a single institutional experience

“…Mean age of presentation in Indian patients is found to be lower than western countries which is seen in western studies; Takalkar et al and Sandhu et al 10,11 In our study majority of patients 49 (98%) presented with breast lump, lump associated with pain in 11 (22%), 3 patients (6%) presented with ulceration, five (10.0%) had a nipple discharge, four (8.0%) showed nipple retraction whereas one (2.0%) presented with Peau'd orange. Our results correlate with study done by Nath et al 12 Tumor size of 3-5 cm was observed in majority of cases (35, 71.43%) followed by tumor size of >5 cm in 14 cases (28.57%). In our study tumor size was >3 cm in all patients which was comparable to other Indian and Asian studies; Acharya et al and Kumar et al 13,14 In contrast, in a study from western countries Taucher et al the tumors are predominantly less than 2 cm.…”

Pattern of Breast Cancer in Women at Child-bearing Age, its Risk Factors and Clinicopathological Evaluation in Tertiary Level Hospital

“…But in studying on clinical presentation of breast carcinoma of 50 cases at Chattagram Maa-O Shishu Hospital reported near about same result and showed stage III & IV were more frequent staging of breast cancer. 18 In this study significant reduction of the risk of developing breast cancer was observed among women whose age at marriage was 18 years or less compared with women whose get age at marriage more than 18 Years. The result was similar to the study of Bhadoria et al 19 The age at which a women gave birth to her first alive child is predictive of breast cancer and the risk increased with age at first birth.…”

“…9, No. 1: [16][17][18][19][20][21] Therefore, in Bangladesh, we estimate an annual new breast cancer case burden of 30,000 women. The prevalence of breast cancer is expected to grow in South Asia due to a combination of increased life expectancy, population growth and adoption of "Western" lifestyles (higher fat diets, reduced activity, reduced parity, delayed child bearing, and decreased breast feeding).…”

Comparison of Estrogen Receptor Status and Ki-67 Index in Core Needle Biopsy and Resected Specimen of Breast Carcinoma

“…17 In addition, the present study found that the most common presenting complaint was palpable lump, which was present in all the cases, and other associated complaints such as pain, nipple discharge, puckering of the skin, nipple retraction and skin ulceration were also observed. The studies by Pervin et al, 16 Al-amri et al 18 and Newton et al 19 observed similar complaints along with pain symptoms, more frequently, in 80% of cases because the patients were unaware of the lump in the early stages of breast carcinoma. Invasive ductal carcinoma NOS was the most common histological type in the CNB and excision specimens.…”

“…Similar observations were made by Pervin et al and Vaibhaw et al 23 wherein the peak incidence of BC is in the fifth decade of life. 16,17 Further, the epidemiological studies at regional and global levels suggest that BC more frequently occurs at the premenopausal age in Indian and Asian women compared with the western women who get it a decade later. 17 In addition, the present study found that the most common presenting complaint was palpable lump, which was present in all the cases, and other associated complaints such as pain, nipple discharge, puckering of the skin, nipple retraction and skin ulceration were also observed.…”