Study on Chronic Renal Injuries Induced by Carbon Tetrachloride: Selective Inhibition of the Nephrotoxicity by Irradiation

Abstract

Carbon tetrachloride (CC1₄) was intraperitoneally injected into Balb/c mice 4 times at biweekly intervals, and the morphological changes of the liver and kidney were examined during 12 weeks after the last injection. The renal injuries progressed in spite of cessation of CC1₄ treatment; microcysts with tubular-cell degeneration were manifest on day 42 after the last injection of CC1₄. At the end of the experiment, however, interstitial fíbrosis with inflammatory cell infiltration was much more prominent. Glomerular changes with IgG deposits also developed following the tubulointerstitial changes. The CC1₄ treatment induced liver damage as well, but it promptly subsided without formation of cirrhosis. The CC1₄ nephrotoxicity was completely inhibited by whole body irradiation (200 rad) exposed at each injection of CC1₄. In contrast, the hepatic damage was not changed by irradiation. These results seem to indicate etiologic independence of renal and hepatic events induced by CC1₄ treatment. It is also suggested that chronic CC1₄ nephrotoxicity is mediated, at least in part, by radiosensitive responses of the mice themselves.

Alteration of renal function by potassium bromate (KBrO3): Protective effects of Launaea procumbens

“…Once filtered, low-molecular-weight proteins are reabsorbed and metabolized by the proximal tubule cells. High level of proteinurea and haematuria in urine of this study showed the nephrotoxicity induced with KBrO 3 (Ogawa et al, 1992).The present study revealed that oral administration of L. procumbens significantly improved creatinine and urobilinogen, and decreased the elevated levels of proteinuria and haematuria. Present study revealed that administration of KBrO 3 caused marked impairment in renal function along with significant oxidative stress in the kidneys.…”

Caffeic acid phenethyl ester protects kidneys against carbon tetrachloride toxicity in rats

“…However, the pathogenesis of CCl 4 -induced renal injury has not been clearly clarified. While Rincon et al (1999) showed that effects of CCl 4 on kidney structure and function depended on the functional state of the liver, Ogawa et al (1992) suggested etiologic independence of the renal Fig. 7.…”

Reduction of carbon tetrachloride‐induced nephropathy by melatonin administration

“…1,3,5,9,10,28 However, the pathogenesis of CCl 4 -induced renal dysfunction has not been elucidated. While Rincon and co-workers 29 showed that the effects of CCl 4 on kidney structure and function depended on the functional state of the liver, Ogawa and co-workers 30 suggested aetiologic independence of the renal and hepatic events. It has been reported that systemically-administered CCl 4 in rats became distributed at higher concentrations in the kidney than in the liver.…”