Alteration of renal function by potassium bromate (KBrO3): Protective effects of Launaea procumbens

Abstract

Potassium bromate (KBrO 3 ) is a nephrotoxin which causes renal oxidative stress and cancer in experimental animal. In the present study, nephroprotective effects of Launaea procumbens against KBrO 3 induced renal function toxicity were determined. In this study, 24 male albino rats (180 to 200 g) were divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and dimethyl sulfoxide (DMSO) (1 ml/kg b.w.), group II was treated with KBrO 3 (20 mg/kg b.w., i.p.), groups III and IV were administered with KBrO 3 and after 48 h with methanolic fractions of L. procumbens (LPME) (100; 200 mg/kg b.w., respectively). All the treatments were given twice a week for 4 weeks. The results revealed that KBrO 3 induced oxidative stress as evidenced by the significant alteration in physical and serum markers of kidney. L. procumbens co-administration dose dependently reversed the physical and serum markers nearly to control groups. The results revealed that LPME can be a useful remedy for renal disorders.