Study on chemical constituents of Folium Artemisiae argyi Carbonisatum, toxicity evaluation on zebrafish and intestinal hemostasis

Gu, Le; Wang, Xueyu; Shao, Xinting; Ding, Yuling; Li, Yong

doi:10.1016/j.jsps.2022.02.018

Cited by 10 publications

(3 citation statements)

References 36 publications

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“…This enhances the activity of GABA, thereby reducing fear and anxiety in mice and alleviating the neurotoxicity of AA ( Liu Y. et al, 2021 ). Additionally, exceeding a dosage of 62.5 μg/mL AA resulted in embryonic developmental toxicity and cardiotoxicity in zebrafish, as evidenced by an increase in spontaneous convulsions and heart rate ( Gu et al, 2022 ).…”

Section: The Toxicity-effect Profile Of Toxic Tcmmentioning

confidence: 99%

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

Li,

Deng,

Xiong

et al. 2023

Front. Pharmacol.

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In Chinese medicine, the primary considerations revolve around toxicity and effect. The clinical goal is to achieve maximize effect while minimizing toxicity. Nevertheless, both clinical and experimental research has revealed a distinct relationship between these two patterns of action in toxic Traditional Chinese Medicines (TCM). These TCM often exhibit characteristic “double-sided” or “multi-faceted” features under varying pathological conditions, transitioning between effective and toxic roles. This complexity adds a layer of challenge to unraveling the ultimate objectives of Traditional Chinese medicine. To address this complexity, various hypotheses have been proposed to explain the toxicity and effect of Traditional Chinese Medicines. These hypotheses encompass the magic shrapnel theory for effect, the adverse outcome pathway framework, and the indirect toxic theory for toxicity. This review primarily focuses on high-, medium-, and low-toxicity Traditional Chinese Medicines as listed in Chinese Pharmacopoeia. It aims to elucidate the essential intrinsic mechanisms and elements contributing to their toxicity and effectiveness. The critical factors influencing the mechanisms of toxicity and effect are the optimal dosage and duration of TCM administration. However, unraveling the toxic-effect relationships in TCM presents a formidable challenge due to its multi-target and multi-pathway mechanisms of action. We propose the integration of multi-omics technology to comprehensively analyze the fundamental metabolites, mechanisms of action, and toxic effects of TCM. This comprehensive approach can provide valuable insights into the intricate relationship between the effect and toxicity of these TCM.

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Section: The Toxicity-effect Profile Of Toxic Tcmmentioning

confidence: 99%

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

Li,

Deng,

Xiong

et al. 2023

Front. Pharmacol.

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“…Essential oil is the main active component of silver wormwood and mainly contains monoterpene and its derivatives, sesquiterpene and its derivatives, ketones (aldehydes), alcohols (phenols), acids (esters), alkanes (alkenes), and other chemical components [3]. Silver wormwood is bitter and pungent in flavor and warm in nature and has the functions of warming meridians, stopping bleeding, dispelling cold, and relieving pain [4]. Silver wormwood has pharmacological effects such as antioxidant, antibacterial, antivirus, antitumor, and immune regulation [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Volatile Components and Antibacterial Activity of Silver Wormwood Essential Oils from Different Habitats by E-Nose Combined with GC-MS

Yang,

Guo,

Yang

et al. 2023

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Electronic nose (E-nose) combined with gas chromatography–mass spectrometry (GC-MS) was used to analyze the volatile components of silver wormwood from different habitats, and the antibacterial activity of essential oils was also studied, to provide a scientific basis for quality control of silver wormwood and rational utilization of their essential oils. In this study, the total content of essential oils in silver wormwood was determined by steam distillation; the volatile components were conducted in an overall analysis by E-nose combined with chemometrics; the volatile components were analyzed and identified by GC-MS; and two G-negative bacteria and one Gram-positive bacteria were used as test bacteria to determine the antibacterial activity of the essential oils from silver wormwood. The results showed that principal component analysis (PCA) and linear discriminant analysis (LDA) of E-nose could distinguish the essential oils of silver wormwood from different habitats, and the odor difference of essential oils was obvious. A total of 87 volatile components were identified by GC-MS, and there were significant differences in components and contents in silver wormwood from different habitats; PCA and hierarchical cluster analysis (HCA) could effectively distinguish silver wormwood from different habitats. The essential oils from silver wormwood from different habitats all had a certain inhibitory effect on Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Therefore, the combination of E-nose and GC-MS could quickly distinguish silver wormwood from different habitats and provide a reference for quality control, drug selection, and comprehensive utilization of silver wormwood.

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“…예로부터 艾葉은 습진과 같은 피부질환이 나 자궁출혈, 월경과다, 월경불순 및 폐경기 질환 과 같은 부인과 질환 및 헐액응고약 등의 목적으 로 사용되어 왔으며, 소염 및 진통완화 효능이 있 는 것으로 알려져 널리 사용되어 왔다 6 . 또한, 艾葉 에는 트리테르페노이드, 플라보노이드 및 탄닌 등 과 같은 성분이 다량 포함되어 있어 우수한 항산 화 효능을 나타내며, 그 외에도 다양한 연구를 통 해 항염증 및 간보호 등의 효과가 있는 것으로 밝 혀졌다 [7][8][9] .…”

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Effect of Artemisiae Argyi Folium Extract on Alcohol-Induced Gastritis

Lee¹,

Seo²,

Kim³

et al. 2022

J Int Korean Med

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Objective: Alcohol is known to cause inflammation in the stomach by decreasing the protective substances of the gastric mucosa and increasing oxidative stress. The purpose of this study was to investigate the anti-inflammatory effect of Artemisiae Argyi Folium extract (AF) on alcohol-induced gastritis.Methods: The total polyphenol and flavonoid contents of AF were confirmed through an in vitro experiment. Radical scavenging activities were confirmed using DPPH and ABTS assays. In vivo experiments were conducted on mice divided into 5 groups (n=8): a normal group (Nor), an alcohol-induced gastritis group (Con), an alcohol-induced gastritis group administered 10 mg/kg sucralfate (SC), an alcohol-induced gastritis group administered 100 mg/kg AF (AFL), and an alcohol-induced gastritis group administered 200 mg/kg AF(AFH). The serum levels of reactive oxygen species (ROS) were determined, and protein expressions were confirmed in gastric tissues.Results: In alcohol-induced gastritis, AF alleviated damage to the gastric mucosa caused by alcohol. AF also decreased the serum ROS levels. Western blots showed that AF decreased the expression of NADPH oxidase and decreased the expression of the NF-κB pathway associated with inflammation. AF also decreased the expression of adhesion molecules and chemokine proteins, and increased the expression of anti-inflammatory proteins.Conclusions: AF not only reduced oxidative stress in alcohol-induced gastritis, but it also relieved gastric mucosal inflammation by regulating the expression of the NF-κB pathway.

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Study on chemical constituents of Folium Artemisiae argyi Carbonisatum, toxicity evaluation on zebrafish and intestinal hemostasis

Cited by 10 publications

References 36 publications

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review

Analysis of Volatile Components and Antibacterial Activity of Silver Wormwood Essential Oils from Different Habitats by E-Nose Combined with GC-MS

Effect of Artemisiae Argyi Folium Extract on Alcohol-Induced Gastritis

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