Study on biologic effects of radon and thermal therapy on osteoarthritis

Yamaoka, Kunihiro; Mitsunobu, Fumihiro; Hanamoto, Katsumi; Mori, Shuji; Tanizaki, Yoshiro; Sugita, Katsuhiko

doi:10.1016/j.jpain.2003.09.005

Cited by 63 publications

(60 citation statements)

References 8 publications

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“…Most conditions treated with radon therapy are lifestyle-related diseases such as arteriosclerosis, osteoarthritis [23], and bronchial asthma [24]. To assess the effects of radon, we have co-developed a radon exposure system (OZ PLAN Co., Ltd. Okayama, Japan); radon inhalation using this system activated antioxidative functions in the liver, kidney, lung, and brain of mice, including suggesting the possibility of a new therapy to treat liver, kidney, lung, and brain damage [25].…”

Section: Introductionmentioning

confidence: 99%

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

et al. 2010

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“…Radon therapy is performed for various diseases, such as ankylosing spondylitis, chronic polyarthritis, spondylosis deformans, osteoarthritis [15], and bronchial asthma [16], at Misasa Medical Center, Okayama University Hospital. Hepatic and renal damage are not the primary indications for radon therapy.…”

Section: Discussionmentioning

confidence: 99%

“…The present study showed that antioxidative functions were significantly higher in mice that had inhaled radon at a concentration of 2000 Bq/m 3 for 24 hr than in control mice. Most conditions treated with radon therapy are pain-related diseases such as osteoarthritis [15] and rheumatoid arthritis [24]. Another research group reported that radon inhalation significantly increased β-endorphin and M-enkephalin which both have morphine-like analgesic effects [25].…”

Section: Discussionmentioning

confidence: 99%

“…Most conditions treated with radon therapy are lifestyle-related diseases, such as arteriosclerosis, osteoarthritis [15], and bronchial asthma [16]. To assess the effects of radon, we have co-developed a radon-exposure system for small animals (OZ PLAN Co., Ltd. Okayama, Japan); using this system we demonstrated that radon inhalation activated antioxidative functions in the liver, kidney, lung, and brain of mice [17].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

et al. 2011

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We assessed whether radon inhalation inhibited carrageenan-induced inflammation in mice.Carrageenan (1% v/v) was injected subcutaneously into paws of mice that had or had not inhaled approximately 2000 Bq/m 3 of radon for 24 hr. Radon inhalation significantly increased superoxide dismutase (SOD) and catalase activity and significantly decreased lipid peroxide levels in mouse paws, indicating that radon inhalation activate antioxidative functions. Carrageenan administration induced paw edema and significantly increased tumor necrosis factor-alpha (TNF-α) and nitric oxide in serum. However, radon inhalation significantly reduced carrageenan-induced paw edema. Serum TNF-α levels were lower the radon-treated mice than in sham-treated mice. In addition, SOD and catalase activity in paws were significantly higher in the radon-treated mice than the sham-treated mice. These findings indicated that radon inhalation had anti-inflammatory effects and inhibited carrageenan-induced inflammatory paw edema.

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“…1 A study demonstrated that liver is not the only target organ of CCl 4 and it causes free radical generation in other organs, such as the brain, heart, lung, and kidney. 2 It has also been reported that CCl 4 administration induces oxidative stress in these organs and that vitamin E (α-tocopherol), which is an antioxidant vitamin, inhibits CCl 4 -induced renal damage.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Inhibitory Effects ofα-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage

et al. 2012

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Since the 2011 nuclear accident in Fukushima, the effects of low-dose irradiation, especially internal exposure, are at the forefront of everyone's attention. However, low-dose radiation induced various stimulating effects such as activation of antioxidative and immune functions. In this study, we attempted to evaluate the quantitative effects of the activation of antioxidative activities in kidney induced by radon inhalation on carbon tetrachloride (CCl 4 )-induced renal damage. Mice were subjected to intraperitoneal (i.p.) injection of CCl 4 after inhaling approximately 1000 or 2000 Bq/m 3 radon for 24 h, or immediately after i.p. injection of α-tocopherol (100, 300, or 500 mg/kg bodyweight). In case of renal function, radon inhalation at a concentration of 2000 Bq/m 3 has the inhibitory effects similar to α-tocopherol treatment at a dose of 300-500 mg/kg bodyweight. The activities of superoxide dismutase and catalase in kidneys were significantly higher in mice exposed to radon as compared to mice treated with CCl 4 alone. These findings suggest that radon inhalation has an antioxidative effect against CCl 4 -induced renal damage similar to the antioxidative effects of α-tocopherol due to induction of antioxidative functions.

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Study on biologic effects of radon and thermal therapy on osteoarthritis

Cited by 63 publications

References 8 publications

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Radon Inhalation Protects Mice from Carbon-Tetrachloride-Induced Hepatic and Renal Damage

Protective Effects of Radon Inhalation on Carrageenan-Induced Inflammatory Paw Edema in Mice

Comparative Study on the Inhibitory Effects ofα-Tocopherol and Radon on Carbon Tetrachloride-Induced Renal Damage

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