Study on Antioxidant and Cytotoxic Activities of Methanolic and Ethyl Acetate Extracts of Peel and Seed of Diospyros blancoi

Setu, Jinnat; Akhter, Ayesha; Rahman, Ratna; Islam, Moriam; Koly, Maviya; Amran,; Foyzun, Tahira

doi:10.9734/arrb/2017/38478

Cited by 4 publications

(4 citation statements)

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“…The result of the present study showed a similar effect using ethanolic extract of D. blancoi in brine shrimp lethality assay wherein an increase of mortality was observed in time and dose dependent manner (Howlder et al, 2012). Similarly, the crude methanolic and crude ethyl acetate extract of the seed and peels of D. blancoi showed cytotoxic activity in brine shrimp lethality assay (Setu et al, 2017). On the other hand, even other plants exhibit toxic effect to the embryo of D. rerio.…”

Section: Resultsmentioning

confidence: 96%

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

Flaviano¹,

Kenniker²,

Ganda³

et al. 2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Section: Resultsmentioning

confidence: 96%

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

Flaviano¹,

Kenniker²,

Ganda³

et al. 2018

Egyptian Academic Journal of Biological Sciences, B. Zoology

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“…Moving to D. discolor , the crude methanol and ethyl acetate extracts of seeds and peels revealed moderate antioxidant action. Reported IC 50 values using DPPH free radical scavenging assay were 13, 37.5, 16.5, and 9.2 μg/mL, respectively (Setu et al, 2017).…”

Section: Pharmacological Actions Of Dsmentioning

confidence: 99%

“…Furthermore, D. discolor crude methanol and ethyl acetate extracts of seeds, and peels, were reported to have moderate cytotoxicity. Reported ED 50 values, using brine shrimp ( Artemia salina ) lethality bioassay technique, were 40, 20, 20, and 10 μg/mL, respectively, compared to the standard vincristine sulphate (ED 50 value = 1.04 μg/mL) (Setu et al, 2017).…”

Section: Pharmacological Actions Of Dsmentioning

confidence: 99%

Unveiling major ethnopharmacological aspects of genus Diospyros in context to its chemical diversity: A comprehensive overview

Fareed

El‐Kersh

Youssef

et al. 2022

Journal of Food Biochemistry

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Diospyros species (DS), “Ebenaceae,” were known for their therapeutic uses in folk medicine since days of yore. Thereafter, scientific evidence related their health benefits to a myriad of chemical classes, for instance, naphthoquinones, flavonoids, tannins, coumarins, norbergenin derivatives, sterols, secoiridoids, sesquiterpenes, diterpenoids, triterpenoids, volatile organic compounds (VOCs), and carotenoids. The available literature showed that more than 200 compounds were isolated and identified via spectroscopic techniques. Many pharmacological activities of DS have been previously described, such as antioxidant, neuroprotective, antibacterial, antiviral, antiprotozoal, antifungal, antiinflammatory, analgesic, antipyretic and cosmeceutical, investigated, and confirmed through versatile in vitro and in vivo assays. Previous studies proved that genus Diospyros is a rich reservoir of valuable bioactive compounds. However, further comparative studies among its different species are recommended for more precise natural source‐based drug discovery and clinical application. Accordingly, this review is to recall the chemical abundance and diversity among different members of genus Diospyros and their ethnopharmacological and pharmacological uses. Practical Applications Practically, providing sufficient background on both secondary metabolites divergence and pharmacological properties of genus Diospyros has many fruitful aspects. As demonstrated below, extracts and many isolated compounds have significant curative properties, which can lead to the discovery of pharmaceutically relevant alternative substitutes to conventional medicine. Consequently, molecular docking on various receptors can be applied. On the grounds, Naoxinqing tablets, a standardized herbal product containing D. kaki leaves extract, have been patented and recorded in Chinese Pharmacopeia as an approved Traditional Chinese Medicine (TCM) for the treatment of cerebro‐ and cardiovascular diseases, although the underlying mechanism remains under advisement. Moreover, the antimicrobial applications of DS are of considerable concern; since the widespread use of antibiotics resulted in different forms of bacterial resistance, hence, limiting and compromising effective treatment. In addition, as a result of contemporary rampant memory disorders, neuroprotective activities of different extracts of DS became of great emphasis.

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“…Minyak dari biji digunakan sebagai obat diare dan disentri, infus buah sebagai obat kumur untuk mengatasi stomatitis (Akter et al, 2015). Buah ini dilaporkan memiliki aktivitas biologi seperti antiinflamasi, analgesik, antimikrob, antikanker, antioksidan, sitotoksik, antidiare, hepatoprotektif, kardioprotektif dan antidiabetes (Setu et al, 2017). Buah naga merah memiliki aktivitas antioksidan dan antiproliferatif (Lourith dan Kanlayavattanakul, 2013) karena banyak mengandung nutrisi, mineral dan komponen bioaktif seperti vitamin (A, B1, B2, B3, C), protein, lemak, karbohidrat, serat, flavonoid, tiamin, niacin, piridoxin, kobalamin, glukosa, fenolik, betasianin, polifenol, karoten, fosfor, zat besi, fitolbumin (Manan et al, 2019;Tsai et al, 2019).…”

Section: Pendahuluanunclassified

Study on Antioxidant Activity Bisbul Pulp and Red Dragon Fruit Stem by Using 1,1-Diphenyl-2-Picrylhydrazin Method

et al. 2020

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Bisbul (Diospyros discolor Willd.) is a plant of the Ebenaceae family and red dragon (Hylocereus polyrhizus) is a plant of the Cactaceae family. Bisbul and red dragon have bioactive compounds are flavonoids that act as antioxidants. The purpose of this study was measure antioxidant activity from ethanol extract of bisbul pulp and ethanol extract of red dragon fruit stem by DPPH method (1,1-diphenyl-2-picrylhydrazin). Extraction by maseration method and using 96% ethanol as solution. Antioxidant activity assay using the immersion method of DPPH measured absorption at a wavelenght 517 nm and compared with vitamin C. The result showed that the ethanol extract of bisbul pulp (IC50 46.00 ìg/mL) more strong antioxidant activity compared the ethanol extract of red dragon fruit stem (IC50 1020.96 ìg/mL).

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Study on Antioxidant and Cytotoxic Activities of Methanolic and Ethyl Acetate Extracts of Peel and Seed of Diospyros blancoi

Cited by 4 publications

References 0 publications

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

Unveiling major ethnopharmacological aspects of genus Diospyros in context to its chemical diversity: A comprehensive overview

Study on Antioxidant Activity Bisbul Pulp and Red Dragon Fruit Stem by Using 1,1-Diphenyl-2-Picrylhydrazin Method

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