Study of zeolite influence on analytical characteristics of urea biosensor based on ion-selective field-effect transistors

Shelyakina, Margaryta K; Солдаткін, О. О.; Arkhypova, V. М.; Kasap, Berna Ozansoy; Akata, Burcu; Dzyadevych, S. V.

doi:10.1186/1556-276x-9-124

Cited by 20 publications

(13 citation statements)

References 14 publications

(13 reference statements)

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“…The sensitivities of the biosensors decreased in the order of BEA-Gold > BEA > nano BEA > Silicalite > GA. BEA zeolites, having aluminium inside, regardless of its particle size, gave higher response than silicalite which has no aluminium in its structure. This result is consistent with our previous results showing that the sensitivity of urease biosensor based on ISFET developed by nano BEA coating is higher compared to silicalite-coated one [ 20 ] and the same trend was observed for amperometric glucose biosensor [ 22 ]. This result can be attributed to the presence of aluminium in zeolite BEA and nano BEA, providing both hydrophilicity and Brønsted acid sites (Si–OH–Al) which are strongly effective in protein adsorption [ 35 , 36 ].…”

Section: Resultssupporting

confidence: 93%

“…We have previously shown the development of new methods for potentiometric [ 20 , 21 ], amperometric [ 22 ] and conductometric [ 8 , 23 ] transducers based on immobilization of enzymes on zeolites. In our recent study, owing to the unique advantages such as easiness, fastness, inexpensiveness and ability to analyse the biological content as electrical signal of electrochemical biosensors with an additional advantage of miniaturized silicon-based semiconductor nature of field-effect transistor (FET)-based sensors, we have developed a novel approach for constructing an ion selective field-effect transistor (ISFET) device for creatinine monitoring using silicalite [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Biosensors Based on Nano-Gold/Zeolite-Modified Ion Selective Field-Effect Transistors for Creatinine Detection

et al. 2017

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The combination of advantages of using zeolites and gold nanoparticles were aimed to be used for the first time to improve the characteristic properties of ion selective field-effect transistor (ISFET)-based creatinine biosensors. The biosensors with covalently cross-linked creatinine deiminase using glutaraldehyde (GA) were used as a control group, and the effect of different types of zeolites on biosensor responses was investigated in detail by using silicalite, zeolite beta (BEA), nano-sized zeolite beta (Nano BEA) and zeolite BEA including gold nanoparticle (BEA-Gold). The presence of gold nanoparticles was investigated by ICP, STEM-EDX and XPS analysis. The chosen zeolite types allowed investigating the effect of aluminium in the zeolite framework, particle size and the presence of gold nanoparticles in the zeolitic framework.After the synthesis of different types of zeolites in powder form, bare biosensor surfaces were modified by drop-coating of zeolites and creatinine deiminase (CD) was adsorbed on this layer. The sensitivities of the obtained biosensors to 1 mM creatinine decreased in the order of BEA-Gold > BEA > Nano BEA > Silicalite > GA. The highest sensitivity belongs to BEA-Gold, having threefold increase compared to GA, which can be attributed to the presence of gold nanoparticle causing favourable microenvironment for CD to avoid denaturation as well as increased surface area. BEA zeolites, having aluminium in their framework, regardless of particle size, gave higher responses than silicalite, which has no aluminium in its structure. These results suggest that ISFET biosensor responses to creatinine can be tailored and enhanced upon carefully controlled alteration of zeolite parameters used to modify electrode surfaces.

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Section: Resultssupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Biosensors Based on Nano-Gold/Zeolite-Modified Ion Selective Field-Effect Transistors for Creatinine Detection

et al. 2017

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“…Recently, potentiometric biosensors prepared adsorbing urease on different zeolite (silicalite, nano beta zeolite, and zeolite L) monolayers were reported by Shelyakina et al . [301]. The zeolite substrates were obtained by immobilizing the zeolite particles onto the surface of pH-sensitive field-effect transistors (ISFET).…”

Section: Adsorbedproteinsmentioning

confidence: 99%

Protein adsorption onto nanomaterials for the development of biosensors and analytical devices: A review

Bhakta

Evans

Benavidez

et al. 2015

Analytica Chimica Acta

219

116

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An important consideration for the development of biosensors is the adsorption of the bio recognition element to the surface of a substrate. As the first step in the immobilization process, adsorption affects most immobilization routes and much attention is given into the research of this process to maximize the overall activity of the bio sensor. The use of nanomaterials, specifically nanoparticles and nanostructured films, offers advantageous properties that can be fine-tuned for interaction with specific proteins to maximize activity, minimize structural changes, and enhance the catalytic step. In the biosensor field, protein-nanomaterial interactions are an emerging trend that span across many disciplines. This review addresses recent publications about the proteins most frequently used, their most relevant characteristics, and the conditions required to adsorb them to nanomaterials. When relevant and available, subsequent analytical figures of merits are discussed for selected biosensors. The general trend amongst the research papers allows concluding that the use of nanomaterials has already provided significant improvements in the analytical performance of many biosensors and that this research field will continue to grow.

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“…An idea of enzyme adsorption on zeolites has been proposed in previous work [ 5 ]. Currently, a number of biosensors based on various types of zeolites have been developed using different enzyme systems: urease [ 6 – 11 ], glucose oxidase [ 12 – 14 ], acetylcholinesterase [ 15 ], butyrylcholinesterase [ 16 , 17 ], invertase/mutarotase/glucose oxidase [ 18 ], etc.…”

Section: Introductionmentioning

confidence: 99%

Creatinine Deiminase Adsorption onto Silicalite-Modified pH-FET for Creation of New Creatinine-Sensitive Biosensor

et al. 2016

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In the work, silicalite particles were used for the surface modification of pH-sensitive field-effect transistors (pH-FETs) with the purpose of developing new creatinine-sensitive biosensor. Creatinine deiminase (CD) adsorbed on the surface of silicalite-coated pH-FET served as a bioselective membrane. The biosensor based on CD immobilized in glutaraldehyde vapor (GA) was taken as control. The creatinine-sensitive biosensor obtained by adsorption on silicalite was shown to have better analytical characteristics (two- to threefold increased sensitivity to creatinine, three- to fourfold lesser response and recovery times, a decrease of the detection limit of creatinine determination to 5 μM, etc.).Additionally, the biosensor based on CD adsorbed on silicalite (Sil/CD) was characterized by high signal reproducibility (relative standard deviation (RSD) for creatinine measurement = 2.6 %) and stability during storage (over 13 months). It was experimentally confirmed that the proposed biosensor was not sensitive either to high concentrations of sodium chloride or to the macromolecular protein fractions and can be used for direct quantitative analysis of creatinine in the blood serum.It was concluded that the method of CD adsorption on silicalite is well-suited for the creation of creatinine-sensitive biosensor with improved working characteristics.

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Study of zeolite influence on analytical characteristics of urea biosensor based on ion-selective field-effect transistors

Cited by 20 publications

References 14 publications

Biosensors Based on Nano-Gold/Zeolite-Modified Ion Selective Field-Effect Transistors for Creatinine Detection

Biosensors Based on Nano-Gold/Zeolite-Modified Ion Selective Field-Effect Transistors for Creatinine Detection

Protein adsorption onto nanomaterials for the development of biosensors and analytical devices: A review

Creatinine Deiminase Adsorption onto Silicalite-Modified pH-FET for Creation of New Creatinine-Sensitive Biosensor

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