Study of Visfatin Level in Type 1 Diabetic Children and Adolescents

Abstract

BACKGROUND:Visfatin is an intracellular enzyme, known as nicotinamide phosphoribosyltransferase (Nampt) and pre-B-cell colony-enhancing factor (PBEF-1). It has insulin-mimetic effects and lowers plasma glucose levels.AIM:The aim of the work was to assess serum concentration of Visfatin in type 1 diabetic children and adolescents and study its relationships with duration of diabetes, body mass index (BMI), glycemic control, insulin dosage, lipid profile and microvascular complications.MATERIAL AND METHODS:Fifty children and adolescents with type 1 diabetes mellitus were recruited with 30 ages and gender-matched healthy subjects. They were subjected to history taking; anthropometric measurements and chronic diabetic complications were recorded if present. Laboratory analysis included urinary microalbumin, serum triglycerides, HDL, LDL, cholesterol, fasting blood glucose, glycosylated Hb (HbA1c) and serum visfatin which was measured with enzyme-linked immunosorbent assay.RESULTS:Diabetic patients showed highly significant decrease in the level of visfatin compared to the control group (P = 0.0001). There was significant further decrease in visfatin level in diabetics with microalbuminuria (n = 13) compared to normoalbuminuric patients (n = 37) (P = 0.015). There was highly significant inverse correlation between visfatin level with age (r = -0.379, p = 0.007), BMI (r = -0.418, p = 0.003), waist circumference (r = -0.430, p = 0.002), hip circumference (r = -0.389, p = 0.005) and microalbuminuria (r = -0.323, p = 0.022).CONCLUSIONS:Type 1 diabetic children and adolescents had a significantly lower visfatin level compared to controls. A marked decrease in the level of visfatin was shown in patients with microalbuminuria with an inverse correlation with BMI suggesting an important role of visfatin in the pathogenesis of type 1 diabetics and type 1 diabetic nephropathy.

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

“…However, results concerning visfatin in T1DM and/or HD are limited and conflicting. In previous studies, circulating visfatin levels in T1DM were higher [80,81] or lower [82][83][84] compared to healthy controls. Recent studies have suggested a relationship between increased visfatin levels and chronic autoimmune thyroiditis [78,85].…”

Comparing the Serum Levels of Adipocytokines in the Renal Transplant Recipients and Healthy Individuals: A Case-Control Study

“…Rafieian-Kopaei and Nasri reported a significant difference of serum Leptin between males and females in 72 renal transplant recipients; there was no relationship between serum Leptin with body mass index, age, and creatinine clearance, however, there was a negative relationship between Leptin and the duration of renal transplantation (22). Comparing the Visfatin serum levels in renal transplant recipients with healthy volunteers, some studies, reported that Visfatin was associated with inflammatory markers and may be able to justify the relationship between inflammation and levels of Adipocytokines in longterm renal transplant recipients (23,24).…”

"Gum Arabic Improves Reproductive Function Associated with Alteration of Testicular Visfatin mRNA Expression in Alloxan Induced Diabetic Rats"

“…Visfatin is upregulated by hypoxia in adipocytes [45], inflammation and hyperglycemia and downregulated by insulin, somatostatin and statins. Previous studies reported that plasma levels and tissue expression of visfatin increased in parallel with diabetes [46]. Visfatin was reported to have insulin-mimetic effects [47] and lowers plasma glucose levels [48].…”