Study of valsartan interaction with micelles as a model system for biomembranes

Čudina, Olivera; Brborić, Jasmina; Janković, Ivana A.; Karljiković‐Rajić, Katarina; Vladimirov, Sote

doi:10.1016/j.colsurfb.2008.03.002

Cited by 47 publications

(19 citation statements)

References 20 publications

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“…In those studies, it was reported that the spectral characteristics of drugs are significantly affected by the presence of surfactants (Banipal et al, ; Caetano and Tabak, ; Cudina et al, ; Enache and Volanschi, ; Erdinc et al, ; Gokturk et al, ; Qian et al, ; Rub et al, ). Those reports also confirmed that there are two types of interactions between drugs and surfactants depending on the chemical structure of both drugs and surfactants i.e., at concentrations below the CMC, a decrease in the absorbance with the appearance of a new band indicates the formation of a complex between drug and surfactant molecules, while above the CMC an increase in the absorption coefficient at high micelle concentrations indicates incorporation of drugs into micelles (Caetano and Tabak, ; Cudina et al, ; Enache and Volanschi, ; Erdinc et al, ; Gokturk et al, ). In this context, the binding constants of drugs to micelles can be quantitatively determined using the simple mathematical model known as the Benesi–Hildebrand equation based on the Beer–Lambert law valid in the high micelle concentration region (Benesi and Hildebrand, ).…”

Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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Absorption spectroscopy, conductivity, and surface tension measurements were carried out at 298 K to study the solubilization of poorly soluble drugs sulfamethoxazole (SMX) and trimethoprim (TMP) in Aerosol‐OT (AOT) micellar media. The binding constants of SMX and TMP to AOT micelles were determined by applying the Benesi–Hildebrand equation. A comparison of the binding constants indicates that the binding tendency of TMP with AOT micelles is higher than that of SMX. To better analyze the incorporation of drugs into anionic AOT micellar media, surface tension measurements were performed in the presence of SMX and TMP in aqueous media. The influence of TMP and SMX on the surface properties of AOT was determined using the Gibbs Adsorption Isotherm. Changes in the surface properties of AOT determined by surface tension measurements in the presence of drugs are in good agreement with the binding constants determined spectrophotometrically. Calculated surface parameters indicate higher incorporation of TMP with AOT than that of SMX. Comparison of the aqueous solubility of TMP and SMX with micellar media indicated solubility enhancements for both poorly soluble drugs. A special attempt was made to highlight simultaneous interactions of TMP and SMX with AOT using both surface tension and conductometric measurements that can be used to determine counterion‐binding parameters.

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Section: Introductionmentioning

confidence: 99%

Interactions and Solubilization of Poorly Soluble Drugs in Aerosol‐OT Micelles

Göktürk

TAMER

2018

J Surfact & Detergents

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“…Ionic (sodium dodecyl sulfate (SDS), cetyltrimetylammonium bromide (CTAB)) and non-ionic surfactants (Triton X-100, Brij-35 and Tweens) are commonly accepted as model systems for studying different aspects of membrane interactions with drug molecules, including their localization [33,34,35]. Because many biological processes occur at the ionizable surface of membranes or in the hydrophobic region, a comparative study of the drug interaction with different charged surfactants may provide information about the nature of the binding forces involved in the drug-membrane interaction [32,33,34,35].…”

Section: Introductionmentioning

confidence: 99%

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

2016

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Abstract:Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed.

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“…[1][2][3][4][5] Because biological membranes are extremely complex multicomponent structures, surfactant micelles with much less complexity have been used as model systems for biomembranes to investigate different aspects of bilayer properties and functions. [6,7] Surfactant micelles have also been widely utilized to increase the solubility of hydrophobic drugs, which is a problem in the formulation of an acceptable dosage form. [8] Drugs may be solubilized in the hydrophobic core and/or on the interface of the micelles.…”

Section: Introductionmentioning

confidence: 99%