Study of the viral interference between infectious pancreatic necrosis virus (IPNV) and infectious haematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss)

Byrne, N.; Castric, J.; Lamour, François; Cabon, Jean-Yves; Quentel, Claire

doi:10.1016/j.fsi.2007.08.010

Cited by 49 publications

(34 citation statements)

References 35 publications

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“…Most published studies have focused on virus-susceptible fish species but have not looked at those species that serve as virus-carriers or reservoirs. These studies are mainly based on evaluation of disease susceptibility and gene expression (focusing on IFN-related genes (IFNs and Mx) but also interleukin (IL)-1b, chemokines or major histocompatibility complex (MHC)) but also have evaluated the involvement of the cellular mechanisms playing after in vitro or in vivo viral exposure of susceptible fish [9][10][11][12][13][14][15][16][17][18][19][20][21][22]. However, the early functional events governing the cellular innate immune responses, apart from interferon (IFN), are almost ignored [9].…”

Section: Introductionmentioning

confidence: 99%

NK-like and oxidative burst activities are the main early cellular innate immune responses activated after virus inoculation in reservoir fish

Esteban

Meseguer

Tafalla³

2008

Fish & Shellfish Immunology

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Section: Introductionmentioning

confidence: 99%

NK-like and oxidative burst activities are the main early cellular innate immune responses activated after virus inoculation in reservoir fish

Esteban

Meseguer

Tafalla³

2008

Fish & Shellfish Immunology

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“…Protection of salmonids from IHNV, viral hemorrhagic septicemia virus (VHSV) and/or infectious salmon anemia virus (ISAV) can be induced by preexposure of fish to infectious pancreatic necrosis virus (IPNV), aquareovirus or picornavirus (de Kinkelin et al 1992, Hedrick et al 1994, LaPatra et al 1995, Johansen & Sommer 2001, Byrne et al 2008. Furthermore, in marine fishes, primary infection of Japanese flounder and sevenband grouper Epinephelus septemfasciatus by aquabirnavirus confers protection from other pathogenic viruses, such as VHSV and fish nodavirus (Pakingking et al 2003(Pakingking et al , 2005.…”

Section: Introductionmentioning

confidence: 99%

“…2A). It was reported recently that protection from IHNV infection induced by preexposure to IPNV (de Kinkelin et al 1992, Byrne et al 2008) was due to induction of IFN activity by the pre-infection with IPNV (McBeath et al 2007, Byrne et al 2008). Thus, the protection from the IHNV challenge observed in the IPNV-IHNV group could likewise be due to induction of IFN activity by pre-infection with IPNV, although expression of Mx gene, an indicator for IFN induction, was not confirmed in the present study.…”

mentioning

confidence: 97%

“…Therefore, development of an IHNV vaccine is essential, and several kinds of efficacious IHNV vaccines have been developed, e.g. killed or attenuated vaccines (Winton 1997, Biering et al 2005, recombinant vaccines with IHNV G protein (Xu et al 1991, Cain et al 1999) and DNA vaccines with IHNV G gene (Anderson et al 1996, Kim et al 2000, Lorenzen et al 2002.Protection of salmonids from IHNV, viral hemorrhagic septicemia virus (VHSV) and/or infectious salmon anemia virus (ISAV) can be induced by preexposure of fish to infectious pancreatic necrosis virus (IPNV), aquareovirus or picornavirus (de Kinkelin et al 1992, Hedrick et al 1994, LaPatra et al 1995, Johansen & Sommer 2001, Byrne et al 2008. Furthermore, in marine fishes, primary infection of Japanese flounder and sevenband grouper Epinephelus septemfasciatus by aquabirnavirus confers protection from other pathogenic viruses, such as VHSV and fish nodavirus (Pakingking et al 2003(Pakingking et al , 2005.…”

mentioning

confidence: 99%

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Protection of rainbow trout from infectious hematopoietic necrosis (IHN) by injection of infectious pancreatic necrosis virus (IPNV) or Poly(I:C)

Kim¹,

Oseko²,

Nishizawa³

et al. 2009

Dis. Aquat. Org.

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It was recently reported that prophylaxis against infectious hematopoietic necrosis virus (IHNV) in fish was induced by pre-exposure to the infectious pancreatic necrosis virus (IPNV). Here the establishment of IHNV immunity in rainbow trout Oncorhynchus mykiss was investigated by IHNV challenge following non-lethal pre-infection with IPNV. Also, synthetic double-stranded RNA polyinosinic polycytidylic acid, Poly(I:C), an inducer for interferon (IFN), was evaluated as a substitute for IPNV induction of the non-specific antiviral state and subsequent IHNV-specific immunity in fish. Rainbow trout pre-infected with IPNV were protected from IHNV challenge 7 d later (relative percentage survival, RPS: 68.8%), and IHNV-specific antibodies were detected in sera from the survivors. Moreover, these surviving fish showed 91.6% RPS when re-challenged with IHNV 28 d after the primary IHNV challenge. Thus, fish appear to acquire IHNV-specific immunity through the IHNV challenge following pre-injection with IPNV. Fish pre-injected with Poly(I:C) were also highly protected from IHNV challenge 2 d later (RPS: 95.2%), and IHNV-specific antibodies were also detected amongst survivors. The survivors showed a 100% survival rate following re-challenge with IHNV both 21 and 49 d after the primary IHNV challenge. Thus, IHNV immunity in rainbow trout is induced by challenge with live IHNV following pre-injection with either IPNV or Poly(I:C). The use of Poly(I:C) to induce an anti-viral state protecting rainbow trout from an otherwise lethal vaccination dose of IHNV may have application to a wider range of fish species and fish pathogenic viruses. KEY WORDS: Immunization · Infectious hematopoietic necrosis virus · IHNV · Poly(I:C) · Interferon · Antiviral state · Dual infection · Vaccine Resale or republication not permitted without written consent of the publisherDis Aquat Org 83: [105][106][107][108][109][110][111][112][113] 2009 be more pathogenic in juveniles. The evolutionary divergence of IHNV influences its pathogenicity, but this has not been elucidated scientifically (Nishizawa et al. 2006a).In seed production facilities for salmonids, stable production of specific-pathogen-free (SPF) fish has been accomplished by measures for the prevention of IHNV transmission, such as disinfection of eggs with iodine, and sterilization of rearing water and facilities. Furthermore, maintenance of SPF-spawners monitored by antibody detection (ELISA) is also important and helpful to prevent vertical transmission of IHNV (Yoshimizu 1996(Yoshimizu , 2003. However, it is still difficult to prevent horizontal transmission of IHNV through water flow in rainbow trout farms. Therefore, development of an IHNV vaccine is essential, and several kinds of efficacious IHNV vaccines have been developed, e.g. killed or attenuated vaccines (Winton 1997, Biering et al. 2005, recombinant vaccines with IHNV G protein (Xu et al. 1991, Cain et al. 1999) and DNA vaccines with IHNV G gene (Anderson et al. 1996, Kim et al. 2000, Lorenzen et al. 2002.Prot...

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“…Izolowany jest z różnych gatunków ryb zarówno morskich, jak i słodkowodnych, jego obecność odnotowuje się również u małży i wrotek (22,24). Wirus IPN często występuje razem z wirusami wywołującymi takie choroby, jak wirusowa posocznica krwotoczna ryb łososiowatych (VHS) (24), zakaźna martwica układu krwiotwórczego ryb łososiowatych (IHN) (4,6,24), śpiączka ryb łososiowatych (SAV) (1) czy zakaźna anemia łososi (ISA) (13). Może rów-nocześnie wystąpić także z bakteryjną chorobą nerek BKD (29).…”

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Role of infectious pancreatic necrosis virus (IPNV) infection in co-infections with other viruses

MAJ-PALUCH¹,

REICHERT²

2018

Medycyna Weterynaryjna

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Maj-Paluch J., Reichert M. Role of infectious pancreatic necrosis virus (IPNV) infection in co-infections with other virusesSummary Co-infection is an infection of more than one pathogen. In an aquatic environment, the most common occurrence is the appearance of infectious pancreatic necrosis virus (IPNV) in the presence of other viruses such as infectious hematopoietic necrosis virus (IHNV), viral hemorrhagic septicemia virus (VHSV), infectious salmon anaemia virus (ISAV), or salmonid alphavirus (SAV). In most cases, the IPN virus reduces the proliferation of other viruses in cell cultures or in the internal organs of salmonids; for example, in IHNV or ISAV co-infections. However, it also happens that there is no significant effect on the multiplication of the virus with which it coexists, e.g. IPNV-VHSV. A body's defense mechanisms, interferon and other interferon-like factors or mutations in the genome play an important role in co-infection.

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Study of the viral interference between infectious pancreatic necrosis virus (IPNV) and infectious haematopoietic necrosis virus (IHNV) in rainbow trout (Oncorhynchus mykiss)

Cited by 49 publications

References 35 publications

NK-like and oxidative burst activities are the main early cellular innate immune responses activated after virus inoculation in reservoir fish

NK-like and oxidative burst activities are the main early cellular innate immune responses activated after virus inoculation in reservoir fish

Protection of rainbow trout from infectious hematopoietic necrosis (IHN) by injection of infectious pancreatic necrosis virus (IPNV) or Poly(I:C)

Role of infectious pancreatic necrosis virus (IPNV) infection in co-infections with other viruses

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