Study of the use of recombinant human granulocyte-macrophage colony-stimulating factor hydrogel externally to treat residual wounds of extensive deep partial-thickness burn

Lin, Yuan; Chen, Minghua; Ding, Fang; Run-xiu, Wang; Ziqiang, Liang; Chengyue, Meng; Jia, Wenbo

doi:10.1016/j.burns.2014.12.004

Cited by 25 publications

(21 citation statements)

References 6 publications

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“…[11,12] Due to its outstanding performance in wound healing, rhGM-CSF has been introduced in treating large-area burn wounds at clinically, [5] and its promotion of the effective healing of infected burn wounds along with infection preventive effect via immune activity modulation have been verified. [13] RhGM-CSF was thought to promote burn wound healing and prevent bacterial infections by improving immune potency.…”

Section: Discussionmentioning

confidence: 99%

“…[6] For instance, rhGM-CSF was reported to suppress sepsis (a whole-body inflammatory response to infection) in burnt mice by restoring T cell and IL-2. [14] Meanwhile, Yuan et al [5] reported that the healing time in the rhGM-CSF group (17.28 ± 6.70 days) was shorter than in the mupirocin ointment group (23.8 ± 4.6 days). Consistently, we found that compared with the placebo group, rhGM-CSF exerted far better efficacy both at the outcomes of wound healing rate and wound healing time.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Therefore, the development of effective drugs which can be directly applied to wounds is of great importance in the treatment of deep second-degree burns.…”

Section: Introductionmentioning

confidence: 99%

“…[5] RhGM-CSF has been proven beneficial in healing both deep burn wounds and leprosy ulcers, indicating its potential in second-degree burns. [6] Because of rhGM-CSF can promote hematopoietic progenitor cell proliferation in bone marrow and aid the transferring of mature cells to the periphery.…”

Section: Introductionmentioning

confidence: 99%

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Recombinant human granulocyte macrophage colony stimulating factor in deep second-degree burn wound healing

Yan

Liu²,

Zhao³

et al. 2017

Medicine

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Background:The aim of this study was to explore the effects of recombinant human granulocyte macrophage colony stimulating factor (rhGM-CSF) on deep second-degree burn wound healing.Methods:In this study, 95 patients with a total of 190 burn wounds were treated with either rhGM-CSF or placebo, separated into 2 groups by treatment type. Wound healing rate, wound healing time, histopathological condition, and scar scale were all compared between the 2 groups.Results:The healing rates in the rhGM-CSF group were remarkably higher than those in the placebo group (P < .01). The wound healing time in the rhGM-CSF group (18.8 ± 7.6 days) was significantly shorter than that in the placebo group (25.5 ± 4.6 days, P < .01). On the 14th day and 28th day, the average optical density of vascular endothelial factor (VEGF) in the rhGM-CSF group was larger than that in the placebo group. Meanwhile, the average optical density of fibroblast growth factor (FGF) in the rhGM-CSF group was also larger than that in the placebo group. Furthermore, the Vancouver scar scale scores of pigmentation, pliability, height, and vascularity were notable lower in the rhGM-CSF group than those in the placebo group (P < .01).Conclusion:The results suggest that rhGM-CSF can significantly accelerate deep second-degree burn wound healing.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[5] Therefore, the development of effective drugs which can be directly applied to wounds is of great importance in the treatment of deep second-degree burns.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Recombinant human granulocyte macrophage colony stimulating factor in deep second-degree burn wound healing

Yan

Liu²,

Zhao³

et al. 2017

Medicine

View full text Add to dashboard Cite

show abstract

“…It has a specific activity on progenitor cells of neutrophils and its administration in experimental animals could increase the neutrophils in bone marrow and blood [14,15]. In addition, it has been applied for treatment of different disorders like thyroid dysfunctions [16,17], embryo teratogenesis in diabetic pregnant mice [18], healing process and extra-hepatic systemic metastases [19,20]. Since MMI severely affect the neonatal development, the aim of this study was to examine the ability of GM-CSF in treating the MMI-induced hypothyroidism in neonatal rats through measurement of serum THs, TSH, GH, IGH-II and TNF-α.…”

Section: Introductionmentioning

confidence: 99%