The sedative activity of the zopnik herb on the model of prolongation of the sleeping action of barbiturate in white rats was studied. As a result of the study, it was found that, in terms of the ability to prolong urethane sleep, Mullein-shaped zopnik is equivalent to the well-known sedative - Regel’s zopnik herb. When studying the sleeping effect, it was shown that the Mullein-shaped zopnik herb does not cause signs of drowsiness compared to the control.