“…5 These activities include antitumoral effects (e.g., tingenone and pristimerin), anti-inflammatory properties (e.g., celastrol), antimicrobial activity (e.g., 1α,29-dihydroxyfriedelan-3-one), cardioprotective effects (e.g., lupeol, 2α-hydroxyursolic acid), antidiabetic activity (e.g., α-amyrin), and antiviral effects (e.g., betulinic acid, oleanolic acid, and ursolic acid). 2,3,5−9 In the present work, the phytochemical study of the hexane extract of S. grandifolia leaves led to the isolation of the new triterpene 28-hydroxyfriedelane-3,15-dione (1), along with seven known triterpenes: friedelan-3-one (2), friedelan-3β-ol (3), friedelane-3,15-dione (4), 15α-hydroxyfriedelan-3-one (5), 28-hydroxyfriedelan-3-one (6), 30-hydroxyfriedelan-3one (7), and 29-hydroxyfriedelan-3-one (8) (Figure 1). The structural elucidation of the new triterpene 1 was established by the analysis of infrared (IR), 1 H and 13 the hexane (EH), chloroform (EC), and ethyl acetate (EAE) extracts, was evaluated against the mouse hepatitis virus 3 (MHV-3), a murine coronavirus that mimics the debilitating conditions of SARS-CoV-2 infections in vivo.…”