Study of the synergistic influence of zwitterionic interactions and graphene oxide on water diffusion mechanism and mechanical properties in hybrid hydrogel network

Hashmi, Saud; Ahmed, Rafiq; Rehman, Adeel Ur; García‐Peñas, Alberto; Zahoor, Awan; Khan, Firoz Shah Tuglak; Vatankhah-Varnosfaderani, Mohammad; Alshahrani, Thamraa; Stadler, Florian J.

doi:10.1016/j.chemosphere.2022.137710

Cited by 6 publications

(3 citation statements)

References 98 publications

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“…Except for PCL_TC, positive kK values were found for the other samples, indicating that the presence of CC promoted a more sustained release of TC, possibly due to intermolecular interactions between TC and CC. The n values were lower than 0.5 for all samples, indicating the predominance of the typical Fickian diffusion mechanisms, 64,67 in which the release is due to the concentration gradient between the carrier (NFs) and the release media. SEM micrographs in Figure S3 obtained after the release essay did not reveal the existence of points of degradation or scoured regions, which could indicate erosions.…”

Section: Tetracycline and Curcuminmentioning

confidence: 84%

Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings

Teodoro,

Alvarenga,

Marques Chagas

et al. 2024

ACS Appl. Polym. Mater.

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Open injuries, resulting from skin tissue ruptures, can expose the human body to pathogenic bacteria, presenting a significant risk for hospitalized patients and individuals with compromised immune systems. At the same time, developing alternative therapies usinginnovative methods of drug administration is crucial for combating antibacterial resistance. In this study, we present an approach for skin wound healing that synergistically combines a traditional antibiotic and an active natural compound in a polymer nanofibrous wound dressing. The fabrication strategy involved the solution blow spinning technique, which enabled easy, fast, and scalable manufacturing of polymer nanofibrous mats, while poly ε-caprolactone (PCL) was selected as the base polymer, due to its biocompatibility and nontoxicity for human tissues. The selected antibiotic formulation comprised a synergistic combination of tetracycline (TC) and curcumin (CC), aiming to incorporate reduced fractions of TC. Nanofibrous dressings measuring around 200 cm 2 could be fabricated during 45 min. The results of physicochemical characterization showed that nanofibrous mats with fewer defects were obtained due to the presence of TC in the formulation, while the presence of CC improved the encapsulation efficiency and enabled a more controlled release of TC. The antimicrobial tests demonstrated that diminishing the quantity of TC in the nanofibrous mats had no discernible impact on their efficacy against Escherichia coli and Staphylococcus aureus. The results of in vitro cytotoxicity and in vivo tests showed that the proposed wound dressings were not cytotoxic (cell viabilities consistently exceeded 95% for human dermal fibroblasts) and did not lead to inflammation or damage in the healing process. Moreover, the study with real wounds on mice showed that the wound dressings containing the synergistic combination of TC and CC exhibited superior efficacy in promoting healing in comparison to the control group. Collectively, these findings demonstrate the potential of the developed nanostructured platfom for wound dressing applications.

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Section: Tetracycline and Curcuminmentioning

confidence: 84%

Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings

Teodoro,

Alvarenga,

Marques Chagas

et al. 2024

ACS Appl. Polym. Mater.

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“…Most conductive fillers are inherently hydrophobic and tend to aggregate within hydrophilic hydrogels when their concentration is increased to achieve adequate conductivity, resulting in detrimental effects on the mechanical properties of the hydrogel. , Hence, it is crucial to select a suitable conductive filler and devise an appropriate method for its integration into the hydrogel network to ensure proper conductivity. Conventional conductive fillers, such as carbon-based materials, − conductive polymers, − MXenes, , and metal particles, , often exhibit poor interfacial compatibility with the flexible hydrogel matrix. Therefore, they are typically modified with hydrophilic substances to enhance their affinity for the hydrogel matrix and mitigate phase separation. , …”

Section: Introductionmentioning

confidence: 99%

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Lu,

Liu,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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Conductive hydrogels incorporating liquid metals, particularly gallium (Ga) droplets, have garnered significant attention owing to the multifaceted functionalities they offer. In this study, we introduce a liquid-metal-based conductive hydrogel synthesized through radical polymerization of acrylic acid (AA) in the presence of Ga droplets stabilized by polyaniline (PANI) nanofibers and xanthan gum (XG) at room temperature. The incorporation of PANI not only enhances the stability of Ga-droplet dispersion but also improves the hydrogel’s mechanical properties, including tensile strength, toughness, and sensitivity as a sensor material. With the addition of 0.5 wt % PANI, the hydrogel displays an elongation at break of 964% and a tensile strength of 265 kPa, while exhibiting a sensor gauge factor (GF) of 13.4 within a strain range of 400–600%. The reversible noncovalent cross-links within the hydrogel confer excellent self-healing properties, achieving 98% self-healing efficiency in elongation at break within 6 h and 90% conductivity self-healing within 83 ms. Additionally, the hydrogel’s abundant functional groups enable strong adhesion to various substrates. As a sensing material, the hydrogel demonstrates rapid response and recovery times (250/250 ms), low detection limits (0.1%), and good durability (500 cycles under 10 and 100% strains). The cross-linked network composed of XG, PANI, and PAA imparts the hydrogel with water retention. Moreover, glycerol treatment reinforces the hydrogel’s mechanical strength and sensing abilities, extending their effectiveness even under extreme temperature conditions. As a result, the XG-PANI-Ga-PAA hydrogel-based strain sensor has emerged as a promising tool for monitoring human health and detecting a wide range of human activities with reliability and precision.

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“…When the water content is higher than 6%, the effect of the water content on permeability is gradually weakened. The water content also plays a role in coal deformation. − The swelling of moist coal in methane and carbon dioxide was analyzed by Day et al, and they observed that the effective compression coefficient of coal pores is reduced with the increase of moisture content, which accounts for the decrease of gas desorption and permeability. Subsequently, a permeability model considering adsorption deformation was established for the moist coal samples.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Evaluation of the Influence of Injected Water on Methane Desorption Behaviors of Coal in the Ordos Basin

Zou,

Liu,

Nie

et al. 2023

Energy Fuels

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Hydraulic fracturing technology is widely utilized to enhance gas drainage efficiency in underground coal mines. Water plays a crucial role in gas migration within coal after water is injected into the coal seams. In this study, methane desorption behaviors of coal were quantitatively evaluated under the influence of the injected water content. X-ray photoelectron spectroscopy (XPS), mercury intrusion porosimetry (MIP), and methane desorption experiments were combined to reveal the influencing mechanism. XPS results show that sample DLT also has the greatest content of the total oxygen-containing groups, which is 99.67% and 176.55% higher than those of samples HJH and BJG, respectively. MIP results indicate that sample DLT has the smallest pore volume (0.0315 cm3/g) and pore surface area (2.79 m2/g), while sample BJG shows the largest pore parameters. It is confirmed that the pore structures of anthracite are more complex than those of bituminous coals. Methane desorption characteristics of anthracite and bituminous coal are affected by injected water to varying degrees. Gas desorption in bituminous B is the most sensitive to the injected water content, and only 6% of the water content triggers a 46.83% reduction of the methane desorption capacity, which is attributed to the less accessible pore space and more hydrophilic oxygen-containing groups. Due to the highly developed pore networks and less oxygen-containing groups, CH4 molecules are replaced by H2O molecules in anthracite at the lower injected water content (<6%), resulting in the increase of the desorption capacity. The higher water content (>6%) accounts for the pore-blocking effect, resulting in the abrupt reduction of the gas desorption capacity.

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Study of the synergistic influence of zwitterionic interactions and graphene oxide on water diffusion mechanism and mechanical properties in hybrid hydrogel network

Cited by 6 publications

References 98 publications

Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings

Synergistic Tetracycline–Curcumin Association in Biocompatible PCL Nanostructured Wound Dressings

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Quantitative Evaluation of the Influence of Injected Water on Methane Desorption Behaviors of Coal in the Ordos Basin

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