Study of the structure-bioactivity of fleximers: synthesis, crystal structure, Hirshfeld surface analysis, and anti-inflammatory assays

Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives

“…The Hirshfeld surface analysis explores the intermolecular contacts and their role in crystal packing 31,32 The Hirshfeld surface mapped on d norm of compounds 1.3, 1.4, and 1.5 are displayed in Fig. S1(A), S2(A), and S3(A) (ESI † ), where the red region indicates the weak interaction contacts with a shorter distance.…”

Effect of a Substituent in the Fourth Position on the Optical Properties of 2-Oxonicotinonitriles

“…2-Oxonicotinonitrile derivatives (2-oxo-1,2dihydropyridine-3-carbonitrile, 3-cyanopyrid-2-one) are of considerable interest due to their diverse applications in various fields of science and technology. Among them, substances were found that are used in pharmaceuticals [1][2][3][4][5][6][7][8][9][10][11][12][13][14], agrochemistry [15], as agents of reducing steel corrosion [16], and in the creation of organic functional materials [17][18][19][20][21][22][23][24][25][26][27][28]. Substituted 2-oxonicotinonitriles are well known for their versatile biological activity.…”

Synthesis of a Pyridone-Based Phthalimide Fleximer and Its Characterization and Supramolecular Property Evaluation

“…Moreover, several 2-pyridone and phthalimide derivatives have good anti-inflammatory activity, − and they have been reported as a feature of various new nonsteroidal anti-inflammatory drugs. − For instance, compounds 1 and 2 (Scheme ) are highly selective and potent inhibitors of COX-2. Compound 1 is a 2-pyridone derivative that has been reported to selectively inhibit the activity of the COX-2 enzyme at a concentration of 1.95 μM, which is comparable to the drug rofecoxib .…”