Study of the optical properties of a thermoresponsive polymer grafted onto porous silicon scaffolds

Pace, Stéphanie; Vasani, Roshan; Cunin, Frédérique; Voelcker, Nicolas H.

doi:10.1039/c2nj40693d

Cited by 45 publications

(49 citation statements)

References 34 publications

(46 reference statements)

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“…The surface chemistry of the samples was first analyzed by attenuated total reflectance–Fourier transform infrared (ATR‐FTIR) spectroscopy. The spectrum obtained for oxidized pSi (Figure (i)) showed a prominent peak at 1100 cm −1 that corresponds to the Si‐ O ‐Si symmetrical stretching peak of silica . Following deposition of the POct film (Figure (ii)), additional peaks at 1375 cm −1 , 1459 cm −1 , 2861 cm −1 and 3000 cm −1 were observed that correspond to the C−H stretching vibrations from the hydrocarbon‐rich polymer layer.…”

Section: Resultsmentioning

confidence: 99%

“…IRS measurements can be used to observe changes in the EOT of the polymer‐modified pSi surface upon swelling or collapse of the polymer layer . Wu and Sailor demonstrated that the Fast Fourier Transforms (FFT) of pSi films coated with relatively thick capping polymer layers displayed two peaks with contributions from the pSi and from the pSi+polymer layers.…”

Section: Resultsmentioning

confidence: 99%

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On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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Chronic wounds are am ajor socio-economic problem. Bacterial infections in such wounds are am ajor contributor to lack of wound healing. An early indicator of wound infection is an increasei np Ho ft he wound fluid. Herein, we describe the development of ap H-responsive drug delivery device that can potentially be used for wound decontamination in situ and on-demand in response to an increaseint he pH of the wound environment. The devicei sb ased on ap orouss ilicon film that provides ar eservoir for encapsulation of an antibiotic within the pores. Loaded porous silicon is capped withd ual plasma polymer layers of poly(1,7-octadiene) and poly(acrylic acid), which provide ap H-responsive barrierf or on-demand releaseo ft he antibiotic. We demonstrate that release of the antibiotic is inhibited in aqueous buffer at pH 5, whereas the drug is released in as ustainable mannera tpH8.Importantly,the released drugwas bacteriostatic against the Pseudomonas aeruginosa woundp athogen. In the future,i ncorporation of the delivery device into wound dressings could potentially be utilized for non-invasive decontamination of wounds.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani

Szili

Rajeev

et al. 2017

Chemistry An Asian Journal

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“…The porosity of the film was simulated from the reflectance spectra using the transfer matrix method [7,16,21], and oscillated between 68.5% and 78.3%. A thickness of 3,530 nm and pore sizes ranging from 25 to 45 nm in diameter were determined using scanning electron microscopy (data not shown).…”

Section: Resultsmentioning

confidence: 99%

Photonic porous silicon as a pH sensor

et al. 2014

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Chronic wounds do not heal within 3 months, and during the lengthy healing process, the wound is invariably exposed to bacteria, which can colonize the wound bed and form biofilms. This alters the wound metabolism and brings about a change of pH. In this work, porous silicon photonic films were coated with the pH-responsive polymer poly(2-diethylaminoethyl acrylate). We demonstrated that the pH-responsive polymer deposited on the surface of the photonic film acts as a barrier to prevent water from penetrating inside the porous matrix at neutral pH. Moreover, the device demonstrated optical pH sensing capability visible by the unaided eye.

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“…While optical sensing based on the degradation of stimulus responsive polymer coatings on pSi has been reported, we show here for the first time the use of pSi as electrochemical transducer combined with the triggered degradation of polymer coatings for electrochemical sensing . The pSi‐THC electrode was coated with crosslinked HYAMA/PEGDA for the electrochemical sensing of the enzyme hyal that is secreted, e.g., by S. aureus .…”

Section: Introductionmentioning

confidence: 95%

Hyaluronic Acid–Modified Porous Silicon Films for the Electrochemical Sensing of Bacterial Hyaluronidase

Tücking

Vasani

Cavallaro

et al. 2018

Macromol. Rapid Commun.

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The development of enzyme-responsive hyaluronic acid methacrylate (HYAMA)-coated porous silicon (pSi) films and their application in electrochemical diagnostic devices for the in situ detection of the enzyme hyaluronidase (hyal), which is secreted by Staphylococcus aureus (S. aureus) bacteria, are reported. The approach relies on a HYAMA-pSi electrode made of thermally hydrocarbonized pSi (pSi-THC) that is impregnated with crosslinked HYAMA/polyethylene glycol diacrylate (PEGDA) hydrogels. The enzymatic degradation of HYAMA by bacterial hyal is monitored by differential pulse voltammetry (DPV) utilizing pSi-THC as a working electrode and ferro/ferricyanide (FF) as external redox probe. The degradation of HYAMA results in reduced diffusion of the redox probe through the partially charged film, thereby enabling the detection of hyal by DPV. In addition to the determination of the concentration-dependent response in NaOAc buffer (pH 5.2), the detection of hyal as indicator for the presence of S. aureus bacteria above a threshold level in bacterial supernatants and artificial wound fluid is highlighted.

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Study of the optical properties of a thermoresponsive polymer grafted onto porous silicon scaffolds

Cited by 45 publications

References 34 publications

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Photonic porous silicon as a pH sensor

Hyaluronic Acid–Modified Porous Silicon Films for the Electrochemical Sensing of Bacterial Hyaluronidase

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