On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Vasani, Roshan; Szili, Endre J.; Rajeev, Gayathri; Voelcker, Nicolas H.

doi:10.1002/asia.201700427

Cited by 30 publications

(33 citation statements)

References 55 publications

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“…Vasani et al. studied the use of porous silicon films to deliver levofloxacin, a drug used to treat bacterial infections, with a wound‐dressing application in mind . The drug was encapsulated by dual plasma polymer layers of poly(1,7‐octadiene) and poly(acrylic acid), providing a pH responsive system for controlled release of levofloxacin.…”

Section: Psi For Drug Deliverymentioning

confidence: 99%

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Tieu

Alba

Elnathan

et al. 2018

Advanced Therapeutics

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This review provides a perspective on porous silicon (pSi)-based nanomaterials including nanoparticles, nanowires, and thin films, that are currently being used in advanced therapy, imaging, and sensing, with a focus on their effective use in future clinical settings. The achievement of both controlled geometry and architecture, and surface chemistry motifs, are presented as the two key parameters that dictate the nature of interactions with the biological entities. The authors discuss the role of the degradation kinetics in a biological environment into nontoxic by-products. pSi is presented as increasingly fulfilling a central task in various biomedical applications and clinical settings, owing to its unique physiochemical properties.

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Section: Psi For Drug Deliverymentioning

confidence: 99%

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Tieu

Alba

Elnathan

et al. 2018

Advanced Therapeutics

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“…In addition, nanostructured pSi has shown unique optical 14 and luminescent properties 11,15 , which are conducive to self-reporting drug loading and release. pSi can be fabricated into films 6,16–20 , microparticles 21–23 or nanoparticles 11,24–27 . Drug loading capacities and release kinetics highly depend on the surface area and surface chemistry of pSi materials 28,29 .…”

Section: Introductionmentioning

confidence: 99%

Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications

Zhang

Yoshikawa

Welch

et al. 2019

Sci Rep

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A new and facile approach to selectively functionalize the internal and external surfaces of porous silicon (pSi) for drug delivery applications is reported. To provide a surface that is suitable for sustained drug release of the hydrophobic cancer chemotherapy drug camptothecin (CPT), the internal surfaces of pSi films were first modified with 1-dodecene. To further modify the external surface of the pSi samples, an interlayer was applied by silanization with (3-aminopropyl)triethoxysilane (APTES) following air plasma treatment. In addition, copolymers of N-(2-hydroxypropyl) acrylamide (HPAm) and N-benzophenone acrylamide (BPAm) were grafted onto the external pSi surfaces by spin-coating and UV crosslinking. Each modification step was verified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy, water contact angle (WCA) measurements, X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). In order to confirm that the air plasma treatment and silanization step only occurred on the top surface of pSi samples, confocal microscopy was employed after fluorescein isothiocyanate (FITC) conjugation. Drug release studies carried out over 17 h in PBS demonstrated that the modified pSi reservoirs released CPT continuously, while showing excellent stability. Furthermore, protein adsorption and cell attachment studies demonstrated the ability of the graft polymer layer to reduce both significantly. In combination with the biocompatible pSi substrate material, the facile modification strategy described in this study provides access to new multifunctional drug delivery systems (DDS) for applications in cancer therapy.

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“…Carboxylic groups such as poly(acrylic acid) (PAAc) and poly(methacrylic acid) (PMAAc), [164] sulfonic acid such as poly(2-acrylamido-2-methylpropane sulfonic acid) (PAMPS) and poly(4-styrenesulfonic acid) (PSSA), [165] phosphonic acid, [166] and boronic acid [167] are the most frequently used acidic groups to develop pH-responsive acidic polymers. Inspired by microorganisms that use flagella for propulsion, researchers fabricated a polymer network using acrylic acid (AAc) as the pH-responsive element along with an acrylamide (AAm)-based hydrogel.…”

Section: Ionization Of Acidic Groupsmentioning

confidence: 99%

Materials, Actuators, and Sensors for Soft Bioinspired Robots

et al. 2020

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This review covers recent advancements in the field of bioinspired soft robotics, with a primary focus on the last 4 years (2017)(2018)(2019)(2020). The review serves as a toolbox for an interdisciplinary audience interested in the most recent bioinspired soft robotic technologies. In particular, it highlights and explores the vital components of soft robots, focusing on the enabling mechanisms and their biological inspirations. The first section discusses the materials used to fabricate soft bio inspired robots. Soft bioinspired actuation and sensing are then discussed, exploring their capabilities and implementation by researchers. Existing challenges and future potentials of bioinspired soft robots are addressed in the concluding remarks. This review provides engineers and scientists with the latest technological advancements and information needed for designing and developing the next generation of soft bioinspired robotic systems. The future applications of these robots will be grand and limitless. Materials Used for Bioinspired Sensors and ActuatorsClassical robotic systems are comprised of rigid bodies, actuators, and sensors. Unfortunately, many of these well-developed actuators and sensors are not transferable to soft bodies. Thus, researchers working in soft robotics need to reinvent actuators and sensors for soft moving bodies. Biological organisms can be an excellent inspiration for designing these soft actuators and sensors, allowing for their integration in both soft and rigid bodies. The design process of soft actuators and sensors have to be initiated with material selection and composition, for they are foundations upon which the actuators and sensors will be built around. Presently, a diversified list of materials has been used in the development of soft robotic systems. This section will cover some of the latest advancements in the last 4 years in the area of material selection and composition for the design and development of soft bioinspired actuators and sensors.During the past 4 years, researchers have produced soft bioinspired actuators and sensors using biological material such as muscle tissue, [23,24] and plant fibers; [25] carbon-based materials such as graphite and graphene oxide (GO) [26][27][28][29][30][31] and carbon nanotubes (CN); [32,33] hydrogel materials such as poly(Nisopropylacrylamide) (PNIPAM), [34,35] liquid crystal elastomers (LCE), [36] dielectric elastomers (DE), [37] and ionic polymermetal composites (IPMC). [38] An overview of these materials (Figure 1), along with their underlying mechanisms, are discussed below.Biological systems can perform complex tasks with high compliance levels. This makes them a great source of inspiration for soft robotics. Indeed, the union of these fields has brought about bioinspired soft robotics, with hundreds of publications on novel research each year. This review aims to survey fundamental advances in bioinspired soft actuators and sensors with a focus on the progress between 2017 and 2020, providing a primer for the materials used i...

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On‐demand Antimicrobial Treatment with Antibiotic‐Loaded Porous Silicon Capped with a pH‐Responsive Dual Plasma Polymer Barrier

Cited by 30 publications

References 55 publications

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Advances in Porous Silicon–Based Nanomaterials for Diagnostic and Therapeutic Applications

Spatially Controlled Surface Modification of Porous Silicon for Sustained Drug Delivery Applications

Materials, Actuators, and Sensors for Soft Bioinspired Robots

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