Study of the Micro- and Nanostructured Silicon for Biosensing and Medical Applications

Kleps, I.; Miu, M.; Simion, Monica; Ignat, Teodora; Brăgaru, Adina; Crǎciunoiu, F.; Dănilă, M.

doi:10.1166/jbn.2009.1035

Cited by 19 publications

(9 citation statements)

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“…Nanostructured porous silicon (nanoPS) has been demonstrated as an excellent candidate for the development of several applications in a broad range of fields including biomedicine, such as drug delivery, tissue engineering, 1,2 protein immobilization and detection, 3,4 virus 5,6 and pesticide 7 detection, or basic cell studies. [8][9][10][11] The standard method for the fabrication of nanoPS allows tailoring its pore size from the micro-to the nanoscale, as well as its optical properties.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, surface micro-and nano-patterning is becoming an important means for enhancing the performance of materials such as creating superhydrophobic surfaces with hierarchical meshporous structures, 14 reprogramming the cell shape, 15 or enlarging cell culture harvest. 16 For the particular case of nanoPS, patterns have been used to promote cell binding or growth [9][10][11]17,18 or to produce label-free biosensors, 3,19 the detection mechanism being based on changes either in the photoluminescence spectra or in the diffraction pattern.…”

Section: Introductionmentioning

confidence: 99%

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Ultraviolet laser patterning of porous silicon

Vega¹,

Peláez

Kuhn

et al. 2014

Journal of Applied Physics

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The role of asymmetric excitation in self-organized nanostructure formation upon femtosecond laser ablation AIP Conf. Proc. 1464, 428 (2012) . In addition, the percentage of transformed to non-transformed region normalized to the pattern period follows similar fluence dependence regardless the period and thus becomes an excellent control parameter. This dependence is fitted within a thermal model that allows for predicting the in-depth profile of the pattern. The model assumes that transformation occurs whenever the laser-induced temperature increase reaches the melting temperature of nanoPS that has been found to be 0.7 of that of crystalline silicon for a porosity of around 79%. The role of thermal gradients across the pattern is discussed in the light of the experimental results and the calculated temperature profiles, and shows that the contribution of lateral thermal flow to melting is not significant for pattern periods !6.3 lm.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ultraviolet laser patterning of porous silicon

Vega¹,

Peláez

Kuhn

et al. 2014

Journal of Applied Physics

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“…The latter strongly depends on the shape and size of the metallic nanostructures and the gaps between them, while porous silicon template helps to manage these properties. The family of the SERS-active nanostructures formed by metal deposition on porous silicon is very rich and includes metallic nanoparticles [ 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ] or polydisperse particles [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 ], dendrites [ 49 , 54 , 83 , 84 ], nanovoids [ 85 ], and metallic oval-shaped NPs [ 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ]. Figure 2 presents schematic views of plasmonic structures that can be formed with a dependence on porous silicon morphology, doping type, the level of silicon, and the method and conditions of metal deposition.…”

Section: Why Porous Silicon Is a Good Template For Sers-active Submentioning

confidence: 99%

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon

et al. 2018

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The present work gives an overview of the developments in surface-enhanced Raman scattering (SERS) with metal-coated porous silicon used as an active substrate. We focused this review on the research referenced to SERS-active materials based on porous silicon, beginning from the patent application in 2002 and enclosing the studies of this year. Porous silicon and metal deposition technologies are discussed. Since the earliest studies, a number of fundamentally different plasmonic nanostructures including metallic dendrites, quasi-ordered arrays of metallic nanoparticles (NPs), and metallic nanovoids have been grown on porous silicon, defined by the morphology of this host material. SERS-active substrates based on porous silicon have been found to combine a high and well-reproducible signal level, storage stability, cost-effective technology and handy use. They make it possible to identify and study many compounds including biomolecules with a detection limit varying from milli- to femtomolar concentrations. The progress reviewed here demonstrates the great prospects for the extensive use of the metal-coated porous silicon for bioanalysis by SERS-spectroscopy.

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“…7,8 Additionally, surface microstructure can substantially enlarge cell alignment and culture. 7,9 Patterns have been fabricated in nanoPS through mask-based processes like ion beam irradiation, 8 anisotropic chemical wet etching followed by porosification, 10 dry soft lithography, 11 stamp pressing, 4 or laser writing. 12,13 However, none of these methods has the capability to offer flexibility in the pattern design over large areas in a time-efficient and single-step process.…”

Section: Dynamics Of Fast Pattern Formation In Porous Silicon By Lasementioning

confidence: 99%

Dynamics of fast pattern formation in porous silicon by laser interference

Peláez

Kuhn

Vega³

et al. 2014

Applied Physics Letters

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Patterns are fabricated on 290 nm thick nanostructured porous silicon layers by phase-mask laser interference using single pulses of an excimer laser (193 nm, 20 ns pulse duration). The dynamics of pattern formation is studied by measuring in real time the intensity of the diffraction orders 0 and 1 at 633 nm. The results show that a transient pattern is formed upon melting at intensity maxima sites within a time <30 ns leading to a permanent pattern in a time <100 ns upon solidification at these sites. This fast process is compared to the longer one (>1 μs) upon melting induced by homogeneous beam exposure and related to the different scenario for releasing the heat from hot regions. The diffraction efficiency of the pattern is finally controlled by a combination of laser fluence and initial thickness of the nanostructured porous silicon layer and the present results open perspectives on heat release management upon laser exposure as well as have potential for alternative routes for switching applications.

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Study of the Micro- and Nanostructured Silicon for Biosensing and Medical Applications

Cited by 19 publications

References 0 publications

Ultraviolet laser patterning of porous silicon

Ultraviolet laser patterning of porous silicon

Progress in the Development of SERS-Active Substrates Based on Metal-Coated Porous Silicon

Dynamics of fast pattern formation in porous silicon by laser interference

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