Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis

Ellakany, Walid Ismail; MoheyEldin, Khaled Mahmoud; Invernizzi, Pietro; ElKady, Ali Mahmoud; Elkheir, Hossam Eldin Fathy Abou; Elwafa, Reham Abdel Haleem Abo; Ellakany, Ahmed

doi:10.1097/meg.0000000000001161

Cited by 9 publications

(4 citation statements)

References 7 publications

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“…The results obtained showed that cells containing the a(-413)-(GT) 30 allele were able to significantly enhance the biological activity of Ho-1. Several studies have subsequently confirmed that the A allele is also associated with a high transcription level of Ho-1, which correlates closely with the occurrence and progression of certain human diseases, including cardiovascular, and liver diseases (58)(59)(60). a previous study reported that the aa genotype of T(-413) A could significantly reduce the occurrence of myocardial infarction and angina pectoris (61).…”

Section: Ho-1 Promoter Polymorphismmentioning

confidence: 90%

“…In addition, studies have shown that patients with liver cirrhosis who carry the HO-1 T allele are more likely to develop esophageal varices than those with liver cirrhosis who carry the A allele. Therefore, the T allele of the HO-1 gene SNP is a risk factor for esophageal varices in patients with cirrhosis ( 60 ).…”

Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 99%

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Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Sun

Wang

et al. 2021

Mol Med Rep

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Heme oxygenase-1 (Ho-1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of Ho-1 is typically low in most cells, it may be highly expressed when induced by a variety of stimulating factors, a process that contributes to the regulation of cell homeostasis. in the 5'-non-coding region of the Ho-1 gene, there are two polymorphic sites, namely the (GT)n dinucleotide and T(-413)a single nucleotide polymorphism sites, which regulate the transcriptional activity of Ho-1. These polymorphisms have been shown to be closely associated with the occurrence and progression of numerous diseases, including cardiovascular, pulmonary, liver and kidney, various types of cancer and viral diseases. The present article reviews the progress that has been made in research on the association between the two types of polymorphisms and these diseases, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases. Contents1. introduction 2. regulation of Ho-1 expression 3. Ho-1 promoter polymorphism 4. association between Ho-1 gene polymorphism and clinical diseases 5. conclusions and prospects

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Section: Ho-1 Promoter Polymorphismmentioning

confidence: 90%

Section: Association Between Ho-1 Gene Polymorphism and Clinical Diseasesmentioning

confidence: 99%

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Sun

Wang

et al. 2021

Mol Med Rep

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“…A previous study showed that in addition to oxidative stress, two other polymorphisms (the GTn repeat length polymorphism and c.‐413A>T [rs2071746]) may affect the expression levels of the HMOX1 gene . Longer GTn repeats and −413 T are associated with lower levels of HMOX1 gene expression and lower HO‐1 activity, which results in being susceptible to nonalcoholic fatty liver disease or oesophageal varices among patients with cirrhosis . To our knowledge, however, few studies have evaluated the role of HMOX1 polymorphisms in drug‐induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study

et al. 2019

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Summary What is known and objective Reactive metabolites from anti‐tuberculosis (anti‐TB) drugs can result in abnormal accumulation of reactive oxygen species (ROS), which plays an important role in anti‐TB drug‐induced liver injury (ATLI). Liver cells could keep the production of ROS in balance by antioxidant activities. The heme oxygenase 1, encoded by the HMOX1 gene and NADH:quinone oxidoreductase 1, encoded by the NQO1 gene are crucial mediators of cellular defense against ROS. The present study aimed to investigate the associations between HMOX1 and NQO1 polymorphisms and ATLI in Chinese anti‐TB treatment population. Methods A matched case‐control study was conducted using 314 ATLI cases and 628 controls. Multivariate conditional logistic regression analysis was used to estimate the association between genotypes and risk of ATLI by the odds ratios (ORs) with 95% confidence intervals (CIs), with weight and use of hepatoprotectant as covariates. Results and discussion Patients carrying the GG genotype at rs2071748 in HMOX1 were at a higher risk of ATLI than those with the AA genotype (adjusted OR = 1.503, 95% CI: 1.005‐2.249, P = 0.047), and significant differences were also found under the recessive (P = 0.015) and additive (P = 0.045) models. Subgroup analysis confirmed the relationship in mild hepatotoxicity cases under the recessive and additive models (adjusted OR = 1.714, 95% CI: 1.169‐2.513, P = 0.006; adjusted OR = 1.287, 95% CI: 1.015‐1.631, P = 0.037, respectively). What is new and conclusion This is the first study to explore the relationship between HMOX1, NQO1 polymorphisms and ATLI in Chinese anti‐TB treatment population. Based on a matched case‐control study, genetic polymorphisms of HMOX1 may be associated with susceptibility to ATLI in the Chinese population.

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“…Sixty five publications studied the vascular complications of liver cirrhosis, for portal hypertension early detection either by invasive or non-invasive procedures and predictors of bleeding (248)(249)(250), invasive management with trans jugular intrahepatic Porto-systemic shunt (251,252) and rectal ozone (253), management of portal hypertensive gastropathy (254), gastric varices diagnosis and different modalities of management and survival (255)(256)(257)(258)(259), esophageal varices from early noninvasive prediction and diagnosis (260-267), management (268)(269)(270)(271)(272)(273) and risk of rebleeding (274,275), small bowel varices (276), and portal hypertensive colopathy (277). Prediction of risk of portal vein thrombosis (278), diagnosis (201,279,280) and survival (281).…”

Section: Liver Cirrhosis and Its Complicationsmentioning

confidence: 99%

Liver diseases among Arab world, current state and unmet needs, a scoping review

Almansoury,

Abdel-Gawad,

Abdelghani

et al. 2023

Global Gastroenterology

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Study of the influence of heme oxygenase 1 gene single nucleotide polymorphism (rs2071746) on esophageal varices among patients with cirrhosis

Abstract: The T allele of heme oxygenase 1 gene SNP polymorphism (rs2071746) is a risk factor for esophageal varices development in cirrhotics.

Cited by 9 publications

References 7 publications

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

Possible association of HMOX1 and NQO1 polymorphisms with anti-tuberculosis drug-induced liver injury: A matched case-control study

Liver diseases among Arab world, current state and unmet needs, a scoping review

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